Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
CDKN2A NM_000077.4:c.322G>C	NCIT_C146941	[A nucleotide substitution at position 322 of the coding sequence of the CDKN2A gene where guanine has been mutated to cytosine.]
ADAM Family Gene	NCIT_C20791	[ADAMs (A Disintegrin and Metalloproteinase Domain) are membrane-anchored proteases that regulate cell behavior by proteolytically modifying the cell surface and extracellular matrix. Currently, the ADAM family has 29 members, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response. (from J Cell Biol 2002;159:893-902 and NCI)]
CDKN2A NM_000077.4:c.322G>T	NCIT_C146943	[A nucleotide substitution at position 322 of the coding sequence of the CDKN2A gene where guanine has been mutated to thymine.]
CDKN2A Gene Mutation	NCIT_C128817	[A change in the nucleotide sequence of the CDKN2A gene.]
CDKN2A NP_000068.1:p.D108Y	NCIT_C146944	[A change in the amino acid residue at position 108 in the cyclin-dependent kinase inhibitor 2 protein where aspartic acid has been replaced by tyrosine.]
Fertilization	NCIT_C16579	[The process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei.]
IL24 Gene	NCIT_C20793	[This gene is involved in cellular growth, differentiation, and apoptosis.]
Interleukin Gene	NCIT_C25982	[Interleukin Genes encode Interleukins, soluble cytokine factors produced by leukocytes and other cell types that have broad functional activities, particularly in regulating the inflammatory and immune responses of a variety of cell types. Interleukins enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli. (NCI)]
CDKN2A NM_000077.4:c.389T>A	NCIT_C146945	[A nucleotide substitution at position 389 of the coding sequence of the CDKN2A gene where thymine has been mutated to adenine.]
CDKN2A NP_000068.1:p.L130Q	NCIT_C146946	[A change in the amino acid residue at position 130 in the cyclin-dependent kinase inhibitor 2 protein where leucine has been replaced by glutamine.]
CDKN2A NM_000077.4:c.439G>A	NCIT_C146947	[A nucleotide substitution at position 439 of the coding sequence of the CDKN2A gene where guanine has been mutated to adenine.]
CDKN2A NP_000068.1:p.A147T	NCIT_C146948	[A change in the amino acid residue at position 147 in the cyclin-dependent kinase inhibitor 2 protein where alanine has been replaced by threonine.]
IKZF1 Gene	NCIT_C68730	[This gene is involved in B-cell and T-cell maturation.]
IKZF1 wt Allele	NCIT_C68731	[Human IKZF1 wild-type allele is located within 7p13-p11.1 and is approximately 123 kb in length. This allele, which encodes DNA-binding protein Ikaros, plays a role in transcriptional enhancement. Truncated and mutated forms of the gene can be a factor in acute lymphoblastic leukemia. A translocation t(3;7)(q27;p12) that fuses the gene to the BCL6 gene is implicated in diffuse large B-cell lymphomas.]
Menhaden Oil	NCIT_C107330	[The oil extracted from various Brevoortia and Ethmidium species. Menhaden oil is used industrially in paint production and the tanning of leather as was as in livestock feeds.]
Mentha arvensis Flower Oil	NCIT_C107331	[The essential oil of Mentha arvensis, the field mint. Mentha arvensis flower oil is used as a flavoring and can also be used for the treatment of skin problems.]
NY-ESO-1 TCR/sr39TK Lentiviral Vector-transduced Autologous PBSCs	NCIT_C146940	[Human autologous peripheral blood stem cells (PBSCs) transduced with a lentiviral vector (LV) encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, and carrying the positron emission tomography (PET) reporter/suicide gene sr39TK, a mutant form of the herpes simplex virus type 1 thymidine kinase gene (HSV-1 TK), with potential immunostimulating and antineoplastic activities. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NY-ESO-1 TCR/sr39TK LV-transduced autologous PBSCs recognize and bind to NY-ESO-1-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive tumor cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types. The incorporation of sr39TK allows for the ganciclovir (GCV)-mediated cell killing of the gene-modified PBSCs if serious adverse effects occur. sr39TK converts the nucleoside prodrug GCV into GCV monophosphate (GCV-MP), which is in turn phosphorylated by cellular kinases to the cytotoxic nucleotide GCV-triphosphate (GCV-TP); the TP form competitively inhibits deoxyguanosine triphosphate (dGTP) incorporation into DNA and inhibits DNA synthesis, causing DNA damage and cell death in the sr39TK-expressing PBSCs. In addition, sr39TK allows for PET imaging of the gene-modified PBSCs upon subsequent administration of radio-labeled substrates, such as 9-(4-[18F]-fluoro-3-[hydroxymethyl]butyl)guanine ([18F]-FHBG). The monophosphorylation of [18 F]-FHBG is catalyzed by sr39TK; this promotes triphosphorylation and accumulation of [18F]-FHBG in the PBSCs, which allows in vivo imaging and tracking of the PBSCs upon PET. Compared to wild-type HSV-TK, the mutant form has increased prodrug phosphorylating capacity and enhances the cell killing by GCV.]
Mustard Oil	NCIT_C107332	[The vegetable oil pressed from seeds or the essential oil extracted from the seeds of Brassica nigra, Brassica juncea, or Brassica hirta. Mustard oil is used as a cooking oil, a source of omega-3 fatty acids, and in various medicinal preparations.]
Myrtle Leaf Oil	NCIT_C107333	[The essential oil of Myrtus communis. Myrtle leaf oil is taken internally for urinary infections, digestive problems, bronchial congestion, and dry coughs.]
Lime Oil	NCIT_C107323	[The oil extracted from the fruit peel of Citrus aurantifolia. Lime oil can be taken as an antioxidant and may help support immune health. Additionally, it is used as a flavoring agent.]