Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Convenient	NCIT_C107497	[Suited for the intended purpose.]
Useful	NCIT_C107498	[Helpful for doing or achieving something.]
Search Engine	NCIT_C68817	[A computer program that retrieves documents or files or data from a database or from a computer network.]
Triphasic	NCIT_C107488	[Occurring in or characterized by three phases or stages.]
Bone Lesion Identification	NCIT_C132466	[The identification of a localized, pathological, or traumatic structural change, damage, deformity, or discontinuity of the bone.]
X Tandem Scoring Engine	NCIT_C68818	[An open source scoring engine from The Global Proteome Machine Organization that can match tandem mass spectra with peptide sequences.]
Tandem Mass Spectrometry Scoring Engine	NCIT_C68824	[A software program that compares the mass of peptide fragments found by tandem mass spectrometry with the expected peptides based on the proteins listed in the fasta file (protein database) that the search is conducted against.]
Australia-Modified Karnofsky Performance Scale	NCIT_C107489	[A measure of an individual's overall performance status or ability to perform their activities of daily living while undergoing care using a single score assigned by a clinician based on observations of a patient's ability to perform common tasks relating to activity, work and self-care.]
New Bone Lesion Lesion Identification	NCIT_C132467	[A localized, pathological, or traumatic structural change, damage, deformity, or discontinuity of the bone that has not been previously seen or characterized.]
Moxetumomab Pasudotox	NCIT_C68819	[A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A (PE38) with potential antineoplastic activity. The Fv portion of anti-CD22 immunotoxin CAT-8015 binds to CD22, a cell surface receptor expressed on a variety of malignant B-cells, thereby delivering the toxin moiety PE38 directly to tumor cells. Once internalized, PE38 induces caspase-mediated apoptosis via a mechanism involving mitochondrial damage and blocks translational elongation by binding to elongation factor 2 (EF-2). Anti-CD22 immunotoxin CAT-8015 exhibits a greater affinity for CD22 than its predecessor, anti-CD22 immunotoxin CAT-3888 (BL22 immunotoxin), and hence may be more effective against tumor cells expressing lower levels of CD22.]
CD22 Immunotoxin	NCIT_C2002	[An immunotoxin composed of an anti-CD22 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)]
B-Lymphocyte	NCIT_C12474	[Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins.]
Mitochondrial Damage	NCIT_C45524	[Mitochondrial Damage involves any process that leads to dysfunction of mitochondria, whether by oxidative damage, mutation of mitochondrial DNA or other by means.]
Elongation Factor 2	NCIT_C38586	[Elongation factor 2 (858 aa, ~95 kDa) is encoded by the human EEF2 gene. This protein plays a role in the GTP-dependent ribosomal A-site to P-site translocation of nascent protein chains.]
Non-target Enhancing Lesion Identification	NCIT_C132468	[The identification of a tumor or lesion that has a well-defined area of unequivocally increased signal intensity on MRI or CT scan images compared with the normal-appearing surrounding tissues, and is not the target of the therapeutic intervention.]
Non-Target Extra Nodal Lesion Identification	NCIT_C132469	[The identification of a tumor or lesion that is present at baseline, located outside of or independent of any lymph nodes, and is not the target of the therapeutic intervention.]
OR Nursing	NCIT_C20879	[Nursing that is concerned with patient care during the preoperative, intraoperative, and postoperative phases of surgery.]
Critical Care Nursing	NCIT_C17602	[Critical care nursing is that specialty within nursing that deals specifically with human responses to life-threatening problems. A critical care nurse is a licensed professional nurse who is responsible for ensuring that all critically ill patients and their families receive optimal care. (AACN)]
Monoclonal Antibody BL-3	NCIT_C29210	[An isotype-matched monoclonal antibody that is used as a control when testing other monoclonal antibodies. (NCI04)]
Monoclonal Antibody 2A11	NCIT_C29211	[A recombinant, murine monoclonal antibody directed against gastrin-releasing peptide, one of a number of bombesin-like peptides (BLP). Tumor cells, such as small cell lung cancer (SCLC) cells, express and secrete BLP that activate specific cell growth-promoting receptors. Monoclonal antibody 2A11 has been shown to decrease the growth of SCLC cells in vitro and in animal models. (NCI04)]