Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
TK Gene	NCIT_C20224	[The TK Gene encodes thymidine kinase, a transferase class pyrimidine salvage enzyme that catalyzes ATP-dependent phosphorylation of thymine deoxyribonucleoside. The TK gene and promoter are used widely in genetic research because of the easily selectable phenotype.]
Reporter Gene	NCIT_C17661	[A gene which produces an easily assayed phenotype. Often used for expression studies of heterologous promoters.]
DNA Interstrand Cross-Link Repair	NCIT_C20225	[DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A number of multi-step DNA repair pathways including nucleotide excision repair, homologous recombination and post-replication/translesion repair all impinge on their repair.]
HL-60/MX1	NCIT_C20230	[HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.]
NCI-60 Cell Line	NCIT_C139309	[A panel of 60 different human cancer cell lines grown in culture that were selected to be used in a drug-screening program to identify and characterize novel compounds for growth inhibition or killing of tumor cell lines.]
EG Cell Line	NCIT_C20231	[Human EG cells are derived from the primordial germ cells, which occurs in a specific part of the embryo/fetus called the gonadal ridge, and which normally develop into mature gametes (eggs and sperm). Growing pluripotent cells derived from EG cells requires the generation of embryoid bodies, which consist of an unpredictable mix of partially differentially cell types.]
Anxiety Disorder Due to a General Medical Condition	NCIT_C34867	[An anxiety disorder in which the symptoms of anxiety have been determined to be the direct physiological consequence of a general medical condition.]
Organic Delusional Syndrome	NCIT_C34869	[A mental disorder caused by intrinsic disease which is characterized by persistent or recurrent irrational beliefs. Consciousness and memory are not affected. It may be broadly classified as a psychotic disorder due to a general medical condition.]
Optic Atrophy	NCIT_C34863	[A disorder characterized by loss of optic nerve fibers. It may be inherited or acquired. Acquired causes include ischemia, optic nerve neuropathy, glaucoma, trauma, radiation, brain tumors, and multiple sclerosis. It leads to vision disturbances.]
Hereditary Optic Atrophy	NCIT_C34864	[A family of inherited disorders characterized by progressive loss of vision secondary to death of the retinal ganglion cell axons that comprise the optic nerve.]
Optical Illusion	NCIT_C34865	[The visual perception of an image that differs from the reality of the image.]
Oral Cavity Submucous Fibrosis	NCIT_C34866	[Chronic, progressive, debilitating and non-reversible fibrosis of the submucosal tissues of the mouth. It is associated with chewing betel quid, a habit practiced in Southeast Asia and India. It is a precancerous condition and results in rigidity of the jaws and inability of the affected individual to open the mouth.]
Congenital Deformity of Hip	NCIT_C34881	[Any anatomic abnormality of the hip that is present at the time of birth.]
Rheumatic Heart Disease	NCIT_C34882	[An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction.]
Multiple Dislocations	NCIT_C34883
Otitis	NCIT_C34884
CY12	NCIT_C20237	[Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.]
CyThera ES Cell Line	NCIT_C20246
CY30	NCIT_C20238	[Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.]
CY40	NCIT_C20239	[Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.]