Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Pituitary Hormone	NCIT_C752	[Pituitary hormones are produced by the pituitary gland, the master gland of the endocrine system which is located at the base of the brain. Levels of pituitary hormones are regulated by the hypothalamus, anterior and posterior lobes of the pituitary gland, and by the pars intermedia.]
AVP Gene	NCIT_C24248	[This gene is involved in growth factor regulation and vasoconstriction.]
SCG2 Gene	NCIT_C21205	[This gene is involved in intercellular communication and in neuroendocrine secretory modulation.]
Activator of Apoptosis Harakiri	NCIT_C21206	[Activator of apoptosis harakiri (91 aa, ~10 kDa) is encoded by the human HRK gene. This protein is involved in the activation of apoptosis.]
Hypertonic Saline	NCIT_C60814	[Any solution of sodium chloride (NaCl) in water with a concentration of NaCl higher than that found in physiological saline (0.9% w/v). When administered in vivo, hypertonic saline (HTS) exhibits several physiological effects beneficial to cerebral injury including: 1) osmotic and vasoregulatory - by promoting the flow of excess water from cerebral tissue to the blood via osmosis and decreasing edema in the vascular endothelium of injured tissues, thus lowering vascular resistance and allowing more blood flow; 2) hemodynamic - by effectively expanding plasma volume; 3) immunomodulatory - by preventing leukocytes from becoming activated and adhering to injured neurons and; 4) neurochemical - by counteracting detrimental excitatory amino acids through the normalization of neuronal cell membranes and by restoration of normal electrolyte and neurotransmitter levels in brain cells, and normal cell volumes.]
Electrolyte Replacement Agent	NCIT_C29730	[Any agent or mixture of agents that are used to replenish electrolytes in body fluids, such as sodium, potassium, calcium, magnesium, phosphorus, chloride and bicarbonate.]
Osmotic Diuretic	NCIT_C49187
Prohibitin	NCIT_C21207	[Prohibitin (272 aa, ~30 kDa) is encoded by the human PHB gene. This protein may be involved in both aging and the regulation of DNA synthesis.]
BRCA1 Associated RING Domain Protein 1	NCIT_C21208	[Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)]
Polyamine Analogue PG11047	NCIT_C60816	[A second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth.]
Polyamine Analogue	NCIT_C49109	[A compound that mimics the naturally occurring polyamines but is modified in such a way that its function differs from that of the natural polyamines and is usually biologically inactive. Polyamine analogues most likely exert their actions through their ability to displace the natural polyamines from their DNA binding sites. Since the natural polyamines are involved in numerous important cellular processes such as cell division, differentiation and membrane function, their displacement from the DNA binding site may lead to an inhibition of cell growth.]
DNA Binding	NCIT_C18597	[Used in reference to proteins or low molecular weight solutes (ligands) that interact specifically with DNA, in either a DNA-sequence dependent or independent fashion.]
Negative Regulation of Cell Differentiation	NCIT_C40740	[Cell Differentiation Inhibition involves interference or restraint of progressive and normally irreversible processes whereby restriction of the developmental potential of immature precursor cells results in increasing specialization of cell function and morphology.]
When You Talk on Phone, How Hard to Understand What Other Person Was Saying	NCIT_C131890	[A question about how hard it was for an individual to understand what the other person was saying while talking on a telephone.]
CHGB Gene	NCIT_C21201	[Encodes Chromogranin B, a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells. Chromogranin functions as a neuroendocrine secretory granule protein which may be the precursor for other biologically active peptides. (LocusLink)]
Adrenal Gland Pheochromocytoma	NCIT_C3326	[A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.]
How Often Hear Ringing, Buzzing, Whistling Noises Only You Could Hear	NCIT_C131891	[A question about how often an individual heard ringing, buzzing or whistling noises that only they could hear.]
Viral Reverse Transcription	NCIT_C21202	[The action of synthesizing a DNA product from a viral RNA template by a viral reverse transcriptase.]
Viral Function	NCIT_C19568	[Biological functions, activities, or processes of viral elements that support the viability, propagation, or maintenance of a virus. (NCI)]
DNA	NCIT_C449	[A long linear double-stranded polymer formed from nucleotides attached to a deoxyribose backbone and found in the nucleus of a cell; associated with the transmission of genetic information.]