Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Ribonucleic Acid	NCIT_C812	[Single-stranded long chain of nucleotides containing ribose. It is the end product of DNA transcription by the enzyme RNA polymerase. It is essential in protein synthesis.]
Tinzaparin Sodium	NCIT_C60810	[The sodium salt of a low molecular weight heparin (LMWH), obtained by controlled enzymatic depolymerization of heparin from porcine intestinal mucosa, with antithrombotic properties. Tinzaparin is a potent inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin); its primary activity is mediated through the plasma protease inhibitor antithrombin. In addition, this agent may inhibit angiogenesis through: 1) competitive binding of the heparin-binding sites on endothelial cells for the proangiogenic cytokines vascular endothelial growth factor (VEGF) and beta-fibroblast growth factor (beta-FGF) and 2) increasing the release of tissue factor pathway inhibitor (TFPI), a negative regulator of angiogenesis.]
Angiogenesis Inhibitor	NCIT_C1742	[An agent or endogenous substance that inhibits the formation of capillaries from existing blood vessels. In cancer therapy, angiogenesis inhibitors preferentially target the new blood vessels that tumors require for oxygen and nutrition, thereby inhibiting the growth and spread of these tumors.]
Low Molecular Weight Heparin	NCIT_C2578	[Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin.]
How Severe Were Ringing, Buzzing, Whistling Noises that Only You Could Hear	NCIT_C131892	[A question about the severity of the ringing, buzzing, or whistling noises that only an individual could hear.]
Bcl-2-Interacting Killer	NCIT_C21203	[Bcl-2-interacting killer (160 aa, ~18 kDa) is encoded by the human BIK gene. This protein plays a role in apoptosis.]
Pediatric Death	NCIT_C60811	[Death of a fetus, neonate, or patient 20 years or younger.]
Dead	NCIT_C28554	[The cessation of life.]
How Much Did Ringing, Buzzing, Whistling Noises Bother You	NCIT_C131893	[A question about how much an individual was bothered by ringing, buzzing, or whistling noises.]
Organic Cation Transporter	NCIT_C21204	[Organic Cation Transporter proteins carry positively charged chemical substances containing covalently bound carbon atoms through solubility barriers, such as lipid membranes or across epithelial layers. After binding substrate, transmembrane transporters often undergo an energy-dependent conformational change that moves the substrate across the membrane with (symport) or against (antiport) concentration gradients.]
Solute Carrier Family	NCIT_C117186	[A large group of integral membrane proteins that are involved in either facilitated or secondary active transport of solutes across cellular membranes. There are over 300 member proteins organized into approximately 50 families. The members of each family share both substrate preference and at least 20% amino acid sequence identity.]
Transmembrane Domain	NCIT_C13410	[The portion of an integral membrane protein crossing through the plasma lemma (cell membrane) or that of an internal vesicle. This region is highly hydrophobic, approximately 20 amino acids long, and bordered by charged amino acids.]
Multiple Deaths And Serious Injuries	NCIT_C60812
Other Finding	NCIT_C36295
Ribosomal Protein	NCIT_C21210	[Proteins present within the ribosomal subunits. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit.]
Translation Process Protein	NCIT_C38576	[Proteins that participate in functions at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a nascent polypeptide chain.]
Ribosome	NCIT_C13274	[Ribosomes are small organelles composed of ribosomal RNA (rRNA) and 80 some different proteins. rRNA is synthesized in the nucleolus and the ribosomal subunits are assembled there from rRNA and imported cytoplasmic made proteins. Once assembled, the subunits pass through the nuclear pores to the cytoplasm where they take part in protein synthesis. Some ribosomes are free in the cytoplasm and can be recruited to a polyribosomal structure when a messenger RNA (mRNA) strand is to be translated into a cytoplasmic protein. Other ribosomes are attached to the endoplasmic reticulum where the protein is formed within the interior to the endoplasmic reticulum. These proteins are destined for secretion, storage or incorporation into membranes.]
60S Ribosomal Protein L13	NCIT_C21211	[60S ribosomal protein L13 (211 aa, ~24 kDa) is encoded by the human RPL13 gene. This protein is involved in translation.]
Angelica Sinensis Root Extract	NCIT_C60817	[An herbal extract derived from the root of the plant Angelica sinensis with possible antiinflammatory, antispasmodic, vasodilatory, estrogenic, and antitumor activities. Angelica sinensis contains volatile oils, including safrole, isosafrole, and n-butylphthalide; coumarin derivatives, including psoralens, bergapten, osthol, imperatorin, and oxypeucedanin; and ferulic acid. The coumarin derivatives in this agent may vasodilate and relax smooth muscle and may exhibit additive anticoagulant effects. Ferulic acid, a phenolic phytochemical present in plant cell walls, may neutralize free radicals such as reactive oxygen species. In addition, Angelica sinensis extract has been shown to inhibit the growth and induce apoptosis of glioblastoma mutltiforme brain tumor cells through p53-dependent and p53-independent pathways.]
Plant or Plant Part Extract	NCIT_C106105	[Any extract from a plant or from part of a plant.]