Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
TAF1 Gene	NCIT_C20421	[This gene is involved in transcriptional initiation, cell cycle progression and ubiquitination.]
Unmethylated MGMT Gene Promoter	NCIT_C132892	[A genetic finding indicating the absence of DNA methylation in the promoter region of the MGMT gene. This finding is associated with a poor prognosis in patients with glioblastoma.]
Mitochondrial Membrane Protein	NCIT_C20422	[Including many peripheral or integral membrane-associated enzymes and transport proteins, Mitochondrial Membrane Proteins are found associated with the smooth outer coat or the highly invaginated inner membrane (cristae) of the semiautonomous, self-reproducing cytoplasmic organelles that constitute the principal site of oxidative phosphorylation (ATP formation) for cellular energy in eukaryotic cells.]
Mitochondrial Membrane	NCIT_C25937	[The double membrane structure surrounding the mitochondrion and separating it from the cell cytoplasm. The two membranes are separated by an intermembrane space. The electron transport chain resides in the inner mitochondrial membrane.]
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8	NCIT_C132893	[Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 8th ed.)]
Helicase	NCIT_C20423	[Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening.]
ATPase	NCIT_C16263	[ATPases are a group of enzymes that catalyze ATP hydrolysis coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA. Many structural (e.g. myosin) and transport (e.g. ion pump) proteins include an ATPase domain.]
PIK3R1 Gene Mutation	NCIT_C132894	[A change in the nucleotide sequence of the PIK3R1 gene.]
PIK3R1 Gene	NCIT_C97733	[This gene is involved in phosphoinositol signaling.]
Angiogenin	NCIT_C20430	[Angiogenin (147 aa, ~17 kDa) is encoded by the human ANG gene. This protein plays a role in the modulation of both vascular development and transcription.]
Interleukin-3	NCIT_C20439	[Interleukin-3 (152 aa, ~17 kDa) is encoded by the human IL3 gene. This protein plays a role in neurotrophic activity and the proliferation of several types of hematopoietic lineage cells.]
Fibroblast Growth Factor 6	NCIT_C20435	[Fibroblast growth factor 6 (208 aa, ~23 kDa) is encoded by the human FGF6 gene. This protein plays a role in the regulation of cell differentiation, cell proliferation, angiogenesis, myogenesis and muscle regeneration.]
Fibroblast Growth Factor 7	NCIT_C20436	[Fibroblast growth factor 7 (194 aa, ~23 kDa) is encoded by the human FGF7 gene. This protein is involved in embryonic development, cell proliferation, cell differentiation, branch formation and keratinocyte growth.]
Macrophage Colony-Stimulating Factor 1	NCIT_C20437	[Macrophage colony-stimulating factor 1 (554 aa, ~60 kDa) is encoded by the human CSF1 gene. This protein is involved in in the regulation of survival, proliferation and differentiation of mononuclear phagocytes.]
Granulocyte Colony-Stimulating Factor	NCIT_C20438
Amphiregulin	NCIT_C20431	[Amphiregulin (252 aa, ~28 kDa) is encoded by the human AREG and AREGB genes. This protein is involved in autocrine and mitogen signaling pathways.]
Betacellulin	NCIT_C20432	[Betacellulin (80 aa, ~9 kDa) is encoded by the human BTC gene. This protein is involved in epidermal growth factor receptor family signaling pathways.]
BTC Gene Product	NCIT_C118372	[A protein encoded by the BTC gene.]
Neuregulin	NCIT_C20433	[Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found to be essential for the normal development of the cardiovascular, pancreatic and nervous systems. Neuregulins are involved in the normal development of mammary gland, are secreted by breast cancer cells, and can alternatively promote or inhibit breast cancer cell division.]
Fibroblast Growth Factor 5	NCIT_C20434	[Fibroblast growth factor 5 (268 aa, ~30 kDa) is encoded by the human FGF5 gene. This protein is involved in hair follicle growth, cell proliferation, and cell differentiation.]