Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Beta-Nerve Growth Factor | NCIT_C20444 | [Beta-nerve growth factor (241 aa, ~27 kDa) is encoded by the human NGF gene. This protein plays a role in both the maintenance and differentiation of sympathetic and sensory neurons.] |
| HPV-Mediated (p16-Positive) Oropharyngeal Cancer pN2 TNM Finding v8 | NCIT_C132871 | [HPV-mediated (p16-positive) oropharyngeal cancer with metastasis in more than four lymph nodes. (from AJCC 8th Ed.)] |
| Brain-Derived Neurotrophic Factor | NCIT_C20445 | [Brain-derived neurotrophic factor (247 aa, ~28 kDa) is encoded by the human BDNF gene. This protein plays a role in both the development of the nervous system and neuronal survival.] |
| Vascular Endothelial Growth Factor A | NCIT_C20450 | [Vascular endothelial growth factor A (232 aa, ~27 kDa) is encoded by the human VEGFA gene. This protein plays a role in both cell proliferation and angiogenesis.] |
| Interleukin-6 | NCIT_C20451 | [Interleukin-6 (212 aa, ~24 kDa) is encoded by the human IL6 gene. This protein is involved in signaling affecting a wide variety of cell types including monocytes, lymphocytes, hepatocytes and nerve cells.] |
| Pleiotrophin | NCIT_C20452 | [Pleiotrophin (168 aa, ~19 kDa) is encoded by the human PTN gene. This protein is involved in the regulation of both neurite outgrowth and cell proliferation.] |
| HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage | NCIT_C132882 | [A term that refers to the staging of HPV-mediated (p16-positive) oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.] |
| Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | NCIT_C132885 | [Stage I includes: (T0, N0, M0); (T0, N1, M0); (T1, N0, M0); (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or more ipsilateral lymph nodes, none larger than 6 cm. M0: No distant metastasis. (AJCC 8th ed.)] |
| Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | NCIT_C132886 | [Stage II includes: (T0, N2, M0); (T1, N2, M0) ;(T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T0: No primary identified. T1: Tumor 2 cm or smaller in greatest dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension. T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or more ipsilateral lymph nodes, none larger than 6 cm. N2: Tumor with contralateral or bilateral lymph nodes metastasis, none larger than 6 cm. M0: No distant metastasis. (AJCC 8th ed.)] |
| MIR124-2 Gene | NCIT_C132887 | [This gene may be involved in gene expression regulation in neurons.] |
| MIR124-2 wt Allele | NCIT_C132888 | [Human MIR124-2 wild-type allele is located in the vicinity of 8q12.3 and is approximately 109 bases in length. This allele, which encodes MIR124-2 pre-miRNA, may play a role in neuronal differentiation.] |
| MIR124-2 Pre-miRNA | NCIT_C132889 | [MIR124-2 pre-miRNA (109 bases) is encoded by the human MIR124-2 gene. This oligonucleotide may be involved in the regulation of neuronal gene expression.] |
| Transforming Growth Factor Beta-1 | NCIT_C20457 | [Transforming growth factor beta-1 (390 aa, ~44 kDa) is encoded by the human TGFB1 gene. This protein is involved in cell proliferation, cell death and a large number of signal transduction pathways.] |
| Transforming Growth Factor-Beta Superfamily | NCIT_C20455 | [A family of structurally-related cytokines that bind to their cognate serine/threonine kinase receptors as homodimers or heterodimers linked by a single disulfide bond. These proteins play a role in embryonic development, hematopoiesis, tissue repair and extracellular matrix remodeling.] |
| Transforming Growth Factor Beta-2 | NCIT_C20458 | [Transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways.] |
| Transforming Growth Factor Beta-3 | NCIT_C20459 | [Transforming growth factor beta-3 (412 aa, ~47 kDa) is encoded by the human TGFB3 gene. This protein is involved in cell proliferation, cell death and embryogenesis.] |
| Transforming Growth Factor | NCIT_C20453 | [Transforming Growth Factors are a family of extracellular signaling peptides involved in cell growth stimulation. Found in hematopoietic tissue, various TGF-beta subtypes stimulate wound healing and may inhibit lymphopoiesis and myelopoiesis. TGF-alpha binds to EGFR and stimulates endothelial cell growth.] |
| HPV-Mediated (p16-Positive) Oropharyngeal Cancer cM1 TNM Finding v8 | NCIT_C132880 | [HPV-mediated (p16-positive) oropharyngeal cancer with distant metastasis. (from AJCC 8th Ed.)] |
| Transforming Growth Factor Alpha | NCIT_C20454 | [Transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation.] |
| TGFA Gene Product | NCIT_C118439 | [A protein encoded by the TGFA gene.] |