Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
DNA-Directed RNA Polymerase II Subunit RPB1	NCIT_C34071	[DNA-directed RNA polymerase II subunit RPB1 (1970 aa, ~217 kDa) is encoded by the human POLR2A gene. This protein is involved in RNA metabolism, transcription and excision repair.]
CTCF wt Allele	NCIT_C73680	[Human CTCF is located within 16q21-22.3 and is approximately 77 kb in length. This allele, which encodes transcriptional repressor CTCF protein, may play a role in transcriptional repression and establishment of heterochromatin boundaries.]
CTCF Gene	NCIT_C73679	[This gene is involved in epigenetic control of gene expression.]
Large Neutral Amino Acids Transporter Small Subunit 3	NCIT_C34073	[Large neutral amino acids transporter small subunit 3 (559 aa, ~61 kDa) is encoded by the human SLC43A1 gene. This protein is involved in the high affinity transport of large neutral amino acids with a preference for those with branched side chains.]
SUV39H2 Gene	NCIT_C73675	[This gene is involved in epigenetic control of gene expression.]
SUV39H2 wt Allele	NCIT_C73676	[Human SUV39H2 wt Allele is located in the vicinity of 10p13 and is approximately 25 kb in length. This allele, which encodes histone-lysine N-methyltransferase SUV39H2 protein, may play a role in transcriptional regulation and epigenetic modification of chromatin.]
DOT1L Gene	NCIT_C73677	[This gene is involved in epigenetic control of gene expression.]
DOT1L wt Allele	NCIT_C73678	[Human DOT1L is located in the vicinity of 19p13.3 and is approximately 66 kb in length. This allele, which encodes histone lysine N-methyltransferase, H3 lysine-79 specific protein, may play a role in transcriptional regulation and epigenetic modification of chromatin.]
KMT5C Gene	NCIT_C73671	[This gene is involved in both heterochromatin persistance and histone methylation.]
KMT5C wt Allele	NCIT_C73672	[Human KMT5C is located in the vicinity of 19q13.42 and is approximately 9 kb in length. This allele, which encodes histone-lysine N-methyltransferase KMT5C protein, may play a role in transcriptional repression and epigenetic modification of chromatin.]
SUV39H1 Gene	NCIT_C73673	[This gene is involved in epigenetic control of gene expression.]
SUV39H1 wt Allele	NCIT_C73674	[Human SUV39H1 is located in the vicinity of Xp11.23 and is approximately 12 kb in length. This allele, which encodes histone-lysine N-methyltransferase SUV39H1 protein, may play a role in transcriptional repression and epigenetic modification of chromatin.]
Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma Isoform	NCIT_C34089	[Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (524 aa, ~61 kDa) is encoded by the human PPP2R5C gene. This protein may play a role in the regulation of protein phosphatase 2A localization.]
Protein Phosphatase 2A Regulatory Protein	NCIT_C34083	[A subunit of protein phosphatase 2A that serves as a scaffold for the formation and localization of the holoenzyme complex and plays a role in the modulation of substrate specificity.]
Serine/Threonine-Protein Phosphatase 2A Activator	NCIT_C34085	[Serine/threonine-protein phosphatase 2A activator (358 aa, ~41 kDa) is encoded by the human PTPA gene. This protein plays a role in both the modulation of protein phosphatase 2A activity and protein folding.]
Spleen Part	NCIT_C38510	[Any component of the organ that is part of the hematopoietic and immune systems consisting of white and red pulp within the left hypochondriac region.]
Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha Isoform	NCIT_C34087	[Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (486 aa, ~56 kDa) is encoded by the human PPP2R5A gene. This protein may play a role in the interactions of protein phosphatase 2A with its substrates.]
Serine/Threonine-Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta Isoform	NCIT_C34088	[Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (497 aa, ~57 kDa) is encoded by the human PPP2R5B gene. This protein may be involved in the localization of protein phosphatase 2A.]
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform	NCIT_C34081	[Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (309 aa, ~36 kDa) is encoded by the human PPP2CB gene. This protein is involved in the dephosphorylation of proteins, the negative regulation of apoptosis and signal transduction.]
DNA (Cytosine-5)-Methyltransferase 1	NCIT_C73690	[DNA (cytosine-5)-methyltransferase 1 protein (1613 aa, ~183 kDa) is encoded by the human DNMT1 gene. This soluble, nuclear protein is involved in epigenetic modification of chromatin, catalyzing the methylation of C5 in CpG dinucleotides within DNA.]