Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Mature B-Cell Non-Hodgkin Lymphoma	NCIT_C7056	[A non-Hodgkin lymphoma that originates from mature B lymphocytes. Representative examples include diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, and small lymphocytic lymphoma.]
ADCS-ADL MCI - Subscore for Item 18	NCIT_C106977	[Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) Subscore for page 8. (Range = 0-3).]
Neoplastic Epithelial Oval Cell	NCIT_C60990
Neoplastic Epithelial Cell	NCIT_C36753
11q Aberration	NCIT_C131912	[A cytogenetic abnormality characterized by deregulation of genes in 11q.]
Cytogenetic Abnormality	NCIT_C2950	[An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material.]
Chromosome 11	NCIT_C13206	[The designation for each member of the eleventh largest human autosomal chromosome pair. Chromosome 11 spans about 134.5 million base pairs and represents between 4 and 4.5% of the total DNA in normal diploid cells.]
ADCS-ADL MCI - ADL Total Score	NCIT_C106978	[Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) ADL total score: sum the page subscores for pages 1-8 of the ADL (items 1-18). (Range = 0-53).]
Malignant Epithelial Oval Cell	NCIT_C60991
Malignant Epithelial Cell	NCIT_C36779
ADCS-ADL Severe Dementia - Description of Usual Performance of Eating	NCIT_C106979	[Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia (ADCS-ADL Severe Dementia) Regarding eating, which best describes subject's usual performance during the last 4 weeks?]
Malignant Epithelial Small Polygonal Cell	NCIT_C60996
Malignant Epithelial Small Cell	NCIT_C36795	[A malignant cell of epithelial origin with a small nucleus and scant amount of cytoplasm.]
Tablet Coated Particle Dosage Form	NCIT_C60997	[A tablet composed of a conglomerate of particles that contains active and/or inert ingredient(s) that have been individually covered with a coating.]
Neoplastic Epithelial Small Oval Cell	NCIT_C60998
Malignant Epithelial Small Oval Cell	NCIT_C60999
Examination	NCIT_C131902	[A formal or careful inspection of an object or subject.]
Oral Docetaxel	NCIT_C131903	[An oral proprietary P-glycoprotein (P-gp) pump inhibitor-based formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, and a P-gp pump inhibitor, with potential antineoplastic activity. Upon administration of oral docetaxel, the P-gp pump inhibitor moiety, which is not absorbed, binds to the P-gp pump in the gastrointestinal (GI) tract and prevents the P-gp pump-mediated efflux of docetaxel from cells the docetaxel has been internalized by back into the GI tract. This decreases P-gp-mediated excretion and enhances absorption of docetaxel. Upon absorption, docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizes tubulin and inhibits microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. The P-gp pump inhibitor enhances the bioavailability of certain poorly bioavailable agents and thereby allows oral administration of those agents. P-gp, an efflux membrane transporter, plays a key role in active drug export, and prevents cellular uptake and accumulation of certain substances.]
Taxane-Pocket Binding Agent	NCIT_C67437	[Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis.]
Gallium Ga 68-NOTA-3PTATE-RGD	NCIT_C131904	[A radiopharmaceutical agent composed of a modified form of the somatostatin analogue octreotate (TATE), linked, via a glutamate linker, to the cyclic tri-amino acid arginine-glycine-aspartic acid (RGD) motif (3PTATE-RGD), and labeled, via the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) with the radioisotope gallium Ga 68, with potential somatostatin receptor type 2 (SSTR2) and alphaVbeta3 (aVb3) integrin imaging activity upon positron emission topography (PET) or single photon emission computed tomography (SPECT). After intravenous administration, gallium Ga 68-NOTA-3PTATE-RGD simultaneously binds to SSTR, with its TATE moiety (with a preference for SSTR2), and to the integrin receptor aVb3 with its RGD moiety. Both SSTR2 and aVb3 are expressed on the membrane of certain tumor cells while minimally or not expressed on healthy, normal cells. Upon PET imaging, SSTR2- and aVb3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. SSTR2 and aVb3 play key roles in tumor proliferation and survival.]