Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Bendazol	NCIT_C74427
Conivaptan	NCIT_C74428
Vasopressin Antagonist	NCIT_C2180	[Substances that antagonize vasopressin, causing, disruption of extracellular fluid volume regulation, vasodilation, and decreased blood pressure and vascular resistance.]
Lixivaptan	NCIT_C74429
Bone Marrow Suppression	NCIT_C74440	[A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow.]
SATB1 Gene	NCIT_C74434	[This gene plays a role in DNA binding.]
BET Bromodomain Inhibitor ZEN-3694	NCIT_C126805	[An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ZEN-3694 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.]
BET Inhibitor	NCIT_C128462
SATB1 wt Allele	NCIT_C74435	[Human SATB1 wild-type allele is located in the vicinity of 3p23 and is approximately 77 kb in length. This allele, which encodes DNA-binding protein SATB1, is involved in DNA binding and may play a role in transcriptional regulation. The expression level of the gene is associated with the metastatic potential of breast cancer cells.]
Caspase Cascade in Apoptosis	NCIT_C91560
Myelofibrosis Transformation in Essential Thrombocythemia	NCIT_C126806	[Myelofibrosis that develops in a patient with history of essential thrombocythemia.]
Secondary Myelofibrosis	NCIT_C27701
DNA-Binding Protein SATB1	NCIT_C74436	[DNA-Binding Protein SATB1 (763 aa, ~86 kDa) is encoded by the human SATB1 gene. This protein binds DNA and may be involved in the regulation of transcription.]
Coroner	NCIT_C126807	[An appointed public official whose job is to identify and certify an individual's death.]
Medical Occupation	NCIT_C19254	[Occupations within the field of medicine.]
PROX1 Gene	NCIT_C74437	[This gene may be involved in both neuronal development and transcriptional regulation.]
Medical Examiner	NCIT_C126808	[A physician, usually a forensic pathologist by training, whose job is to determine the cause of an individual's death and perform autopsies.]
Beclotiamine	NCIT_C74430
B Vitamin	NCIT_C45812	[A class of nutrients that are in the water-soluble B-vitamin family. B vitamins include thiamine, riboflavin, niacin (nicotinic acid), niacinamide (nicotinamide), the vitamin B6 group (including pyridoxine, pyridoxal, pyridoxamine), biotin, pantothenic acid, folic acid, and possibly para-aminobenzoic.]
EpCAM-specific CAR-expressing Autologous T-lymphocytes	NCIT_C126801	[A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the antigen epithelial cell adhesion molecule (EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration, the EpCAM-specific CAR-expressing autologous T-lymphocytes specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. EpCAM, a cell surface protein, is expressed by a variety of tumor cells.]