Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Chimeric Antigen Receptor T-cells | NCIT_C137999 | [Autologous or allogeneic T-lymphocytes that are engineered to contain a chimeric antigen receptor (CAR) that specifically targets a particular antigen.] |
| Sumarotene | NCIT_C74431 | |
| Vitamin A Compound | NCIT_C938 | [A compound containing vitamin A, a natural, fat-soluble vitamin that plays a vital role in a variety of physiologic processes including immune function, vision, reproduction, and cellular growth and differentiation. Upon administration, the various forms of vitamin A are solubilized into micelles in the intestinal lumen and absorbed by duodenal mucosal cells.] |
| Phytochlorin Sodium-Polyvinylpyrrolidone Complex | NCIT_C126802 | [A photosensitizer composed of the sodium salt form of chlorin e6 and its derivatives complexed with a low-molecular weight polyvinylpyrrolidone (PVP) polymer component, with diagnostic and antineoplastic activities upon photodynamic therapy (PDT). Upon intravenous administration, the photosensitizer phytochlorin-PVP sodium complex preferentially accumulates in hyperproliferative tissues, such as tumors. Local application of light with a certain wavelength to the tumor site results in the absorption of light by this agent leading to its photoactivation. This results in a photodynamic reaction between phytochlorin and oxygen, which causes the production of reactive oxygen species (ROS), including singlet oxygen molecules, the superoxide ion, and other cytotoxic free radicals. The formation of ROS induces free radical-mediated oxidative DNA damage followed by apoptosis of tumor cells. Chlorin e6-PVP is able to penetrate deeply into tissues and is therefore able to treat hard-to-reach tumors.] |
| Ecalcidene | NCIT_C74432 | |
| Vitamin D Analog | NCIT_C39713 | |
| Tris-acryl Gelatin Microspheres | NCIT_C126803 | [An embolic particle composed of water-soluble, compressible, nonabsorbable microspheres composed of tris-acryl gelatin, with potential use for embolization. Upon administration, the tris-acryl gelatin microspheres (TAGM) serve as an embolic agent before surgery for highly vascularized areas, such as those seen in certain tumors, by penetrating into the blood vessel system and blocking blood flow. These microspheres may be used to encapsulate various therapeutic agents; drug-loaded microspheres can then be used as drug delivery vehicles during embolization of tumor vasculature.] |
| Synthetic Polymer | NCIT_C82130 | [Synthetic high molecular weight molecules made up of a linked series of repeated monomeric subunits. The monomers can be of the same or different composition.] |
| gp100:154-162-Reactive Peripheral Blood Lymphocytes Present | NCIT_C74433 | |
| Anti-ICOS Agonist Antibody GSK3359609 | NCIT_C126804 | [An agonistic antibody for the inducible T-cell co-stimulator (ICOS; CD278), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-ICOS agonist antibody GSK3359609 targets and binds to ICOS expressed on tumor infiltrating CD4-positive T-cells. This stimulates ICOS-positive T-cell proliferation, enhances cytotoxic T-lymphocyte (CTL) survival and increases CTL-mediated immune responses against tumor cells. ICOS, a T-cell specific, CD28-superfamily costimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T-cells and plays a key role in the proliferation and activation of T-cells.] |
| Anti-ICOS Monoclonal Antibody | NCIT_C141145 | |
| CEBPA-targeting saRNA MTL-CEBPA Liposome | NCIT_C126800 | [A lipid-based nanoparticle formulation composed of liposomes encapsulating a small oligonucleotide encoding a small activating RNA (saRNA) targeting the CCAAT enhancer binding protein alpha (CEBPA; C/EBP-a) gene, with potential antineoplastic activity. Although the exact mechanism of action through which saRNAs exert their effect(s) is still largely being investigated, it appears that, upon administration, the CEBPA-targeting saRNA MTL-CEBPA liposome targets and binds to a specific DNA regulatory target region, most likely the promoter region, for the CEBPA gene. This restores CEBPA gene transcription, and increases both CEBPA mRNA levels and protein expression. This in turn activates the expression of tumor suppressor genes and may halt proliferation of susceptible tumor cells. Specifically, upregulation of CEBPA in liver cells abrogates liver cancer cell proliferation, thereby prevents liver failure and normalizes liver function. CEBPA, a transcription factor that plays a key role in the regulation of the expression of genes with many functions, including those involved in cellular proliferation, metastasis and normal hepatocyte function, is found in many tissues, including liver cells, adipose tissue and myeloid cells. CEBPA is downregulated in certain types of cancer cells, such as liver cancer cells. saRNA is a short, double-stranded RNA that is structurally related to siRNAs; saRNA is most likely to bind to a target site on the promoter of the CEBPA gene and upregulates its gene expression.] |
| PROX1 wt Allele | NCIT_C74438 | [Human PROX1 wild-type allele is located within 1q32.2-q32.3 and is approximately 53 kb in length. This allele, which encodes homeobox prospero-like protein PROX1, may play a role in both regulation of gene expression and neuronal development. Aberrant expression may play a role in tumor initiation.] |
| Homeobox Prospero-Like Protein PROX1 | NCIT_C74439 | [Homeobox prospero-like protein PROX1 (737 aa, ~83 kDa) is encoded by the human PROX1 gene. This protein may be involved in transcriptional modulation.] |
| Luffa operculata | NCIT_C74492 | |
| Mikania parviflora | NCIT_C74493 | |
| Morus alba | NCIT_C74494 | |
| Paspalum distichum | NCIT_C74495 | |
| Hyssopus officinalis | NCIT_C74490 | |
| Lophophora williamsii | NCIT_C74491 |