Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Brain Natriuretic Peptide 32	NCIT_C88523	[Brain natriuretic peptide 32 (32 aa, ~3 kDa) is encoded by the human NPPB gene. This protein plays a role in the modulation of diuresis, vasorelaxation and secretion of renin and aldosterone.]
N-Terminal Fragment Brain Natriuretic Protein	NCIT_C88524	[N-terminal fragment brain natriuretic protein (76 aa, ~9 kDa) is encoded by the human NPPB gene. This protein is a marker for cardiac failure.]
Heart Failure	NCIT_C50577	[Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction.]
Protein Fragment	NCIT_C28566	[A fragment of a protein, which may be a diagnostic or prognostic factor and used as a biomarker. (NCI)]
Cell Defense Process	NCIT_C51040
Interferon Signaling Process	NCIT_C40586	[Any process which promotes expression of the interferon proteins, their subsequent secretion, binding to cognate receptors or intracellular signaling, and promotes antigen presentation by T lymphocytes, interference with viral replication, and activation of NK cells and macrophages. This process is involved in modulating functions of the immune system.]
Merkel Cell Carcinoma pN1a TNM Finding v7	NCIT_C88529	[Merkel cell carcinoma with micrometastasis in regional lymph node(s). Micrometastases are diagnosed after sentinel or elective lymphadenectomy. (from AJCC 7th Ed.)]
Platelet Activating Factor Signaling Process	NCIT_C40592	[Any process which promotes degranulation of platelets and release of platelet-activating factor into the plasma, resulting in signaling through the G protein-coupled platelet-activating factor receptor and aggregation of platelets. This process is involved in platelet aggregation, inflammation and anaphylaxis.]
Negative Regulation of Immunologic Factor Signaling	NCIT_C40593	[Any physiologic process which occurs in response to ligation of an immunologic factor receptor with its cognate ligand, and results in a reduced number of active signaling molecules within the target cell. This process is involved in regulating the extent of the response to receptor binding, as well as regulating active populations of immune cells.]
Merkel Cell Carcinoma pN1b TNM Finding v7	NCIT_C88530	[Merkel cell carcinoma with macrometastasis in regional lymph node(s). Macrometastases are defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or needle biopsy. (from AJCC 7th Ed.)]
Merkel Cell Carcinoma pN2 TNM Finding v7	NCIT_C88531	[Merkel cell carcinoma with in transit metastasis. In transit metastasis is defined as a tumor distinct from the primary lesion and located either (1) between the primary lesion and the draining regional lymph nodes or (2) distal to the primary lesion. (from AJCC 7th Ed.)]
NHEJ1 wt Allele	NCIT_C88514	[Human NHEJ1 wild-type allele is located in the vicinity of 2q35 and is approximately 85 kb in length. This allele, which encodes nonhomologous end-joining factor 1 protein, plays a role in the mediation of both V(D)J recombination and the repair of damaged DNA. Mutation of the gene is involved in a form of severe combined immunodeficiency.]
NHEJ1 Gene	NCIT_C88513	[This gene is involved in DNA repair and V(D)J recombination.]
Non-Homologous End-Joining Pathway	NCIT_C91444
2q35	NCIT_C13763	[A chromosome band present on 2q]
MSR1 wt Allele	NCIT_C112505	[Human MSR1 wild-type allele is located in the vicinity of 8p22 and is approximately 450 kb in length. This allele, which encodes macrophage scavenger receptor types I and II protein, is involved in the modulation of cholesterol and lipoprotein transport. Mutation of the gene is associated with Barrett esophagus and prostate cancer.]
MSR1 Gene	NCIT_C112504	[This gene plays a role in the transport of both lipoproteins and cholesterol.]
Phagocytosis Pathway	NCIT_C91809
8p22	NCIT_C13388	[A chromosome band present on 8p]
Nonhomologous End-Joining Factor 1	NCIT_C88515	[Non-homologous end-joining factor 1 (299 aa, ~33 kDa) is encoded by the human NHEJ1 gene. This protein is involved in both the repair of double-strand breaks in DNA and nonhomologous end-joining.]