Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Daylight-Savings Time	NCIT_C112506	[A seasonal time adjustment in which clocks are set one hour ahead of local standard time.]
Catecholamine	NCIT_C88516	[A group of sympathetic amines containing a catechol group derived from the amino acid tyrosine. Catecholamines are hormones and neuromodulators synthesized in the chromaffin cells of the adrenal glands and the postganglionic fibers of the sympathetic nervous system in response to stress. Examples of catecholamines are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine, all of which participate in a wide variety of functions throughout the body.]
Neurotransmitter	NCIT_C687	[Endogenous signaling molecules that alter the behavior of neurons or effector cells. Neurotransmitter is used here in its most general sense, including not only messengers that act directly to regulate ion channels, but also those that act through second messenger systems, and those that act at a distance from their site of release. Included are neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not acting at synapses.]
Hormone	NCIT_C2315
Macrophage Scavenger Receptor Types I and II	NCIT_C112507	[Macrophage scavenger receptor types I and II (451 aa, ~50 kDa) is encoded by the human MSR1 gene. This protein plays a role in cholesterol and lipoprotein transport.]
ORAI1 Gene	NCIT_C88517	[This gene plays a role in calcium transport and T-cell-mediated immune responses.]
Severe Combined Immunodeficiency	NCIT_C3472	[X-linked or autosomal recessive disorder characterized by defects of both humoral and cell mediated immunity, resulting in low or absent antibody levels, leukopenia, marked susceptibility to infections, and early death.--2004]
T-Cell Differentiation	NCIT_C19055	[Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction. Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells. (NCI/OSP)]
Water Bath	NCIT_C112508	[A device designed to regulate the temperature of a vessel by bathing it in water held at the desired temperature.]
Merkel Cell Carcinoma pT4 TNM Finding v7	NCIT_C88510	[Merkel cell carcinoma with primary tumor invading bone, muscle, fascia, or cartilage. (from AJCC 7th Ed.)]
Merkel Cell Carcinoma Pathologic Primary Tumor TNM Finding v7	NCIT_C88499	[A pathologic finding about one or more characteristics of Merkel cell carcinoma, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. The TNM pathologic and clinical primary tumor classifications of Merkel cell carcinoma are the same. (from AJCC 7th Ed.)]
DGKA Gene	NCIT_C112501	[This gene is involved in phospholipid metabolism.]
Hypoproteinemia	NCIT_C88511	[A laboratory test result indicating abnormally low levels of total protein in the serum.]
DGKA wt Allele	NCIT_C112502	[Human DGKA wild-type allele is located in the vicinity of 12q13.3 and is approximately 27 kb in length. This allele, which encodes diacylglycerol kinase alpha protein, plays a role in lipid phosphorylation and the attenuation of second messenger signaling.]
Socialization	NCIT_C88512	[The process of learning and adopting behavioral patterns that conform with the surrounding culture.]
Diacylglycerol Kinase Alpha	NCIT_C112503	[Diacylglycerol kinase alpha (735 aa, ~83 kDa) is encoded by the human DGKA gene. This protein is involved in the negative regulation of second messenger signaling through lipid phosphorylation.]
Severe Combined Immunodeficiency with Absence of T and B Cells	NCIT_C61238	[An inherited, severe immunodeficiency disorder characterized by abnormalities in the development and function of T and B cell immunity. The peripheral T and B lymphocytes are absent or in very low counts.]
Nonhomologous DNA End Joining	NCIT_C20207	[Non-homologous DNA end joining (NHEJ) can only repair double-strand breaks in which two DNA ends are rejoined by DNA ligase at regions of little or no homology to avoid degradation by DNA nucleases or noncomplementary overhanging ends. However, the disadvantage is that it can lead to loss of information from the DNA because of resection of the broken ends. NHEJ is operational throughout the cell cycle but may be more important during G1, prior to DNA replication, or in cells that are no longer cycling.]
BET Inhibitor RO6870810	NCIT_C112500	[A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor RO6870810 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones. This interaction disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth.]
ORAI1 wt Allele	NCIT_C88518	[Human ORAI1 wild-type allele is located in the vicinity of 12q24.31 and is approximately 15 kb in length. This allele, which encodes calcium release-activated calcium channel protein 1, is involved in the modulation of both T-cell pathogen response and calcium influx. Mutation of the gene is associated with congenital severe combined immunodeficiency.]