Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
interleukin-2/Monoclonal Antibody OKT3	NCIT_C15612
Muromonab-CD3	NCIT_C1321	[A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction.]
interleukin-2/Monoclonal Antibody OKT3/Tumor Necrosis Factor	NCIT_C15613
interleukin-2/Monoclonal Antibody OKT3/pentoxifylline	NCIT_C15614
Pentoxifylline	NCIT_C733	[A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.]
gp100 Antigen/Incomplete Freund's Adjuvant	NCIT_C15615
gp100 Antigen	NCIT_C2386	[A melanoma-associated antigen. When administered in a vaccine formulation, gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumors that express this antigen, which may result in a reduction in tumor size. (NCI04)]
Monoclonal Antibody 17-1A/sargramostim	NCIT_C15617
Edrecolomab	NCIT_C1554	[A murine monoclonal IgG2a antibody to tumor-associated epithelial cell adhesion molecule (EpCAM, or 17-1A) antigen. Edrecolomab attaches to EpCAM, a human cell surface glycoprotein that is found on normal epithelial cells and some tumor cells, such as those of colon and breast carcinomas. Upon binding, this agent recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity. (NCI04)]
Cancer and Suicide	NCIT_C15618
Social Aspects of Cancer	NCIT_C15891	[Influence of social factors, such as community, policy, and legislation on cancer control and outcomes]
Edetate Calcium Disodium/Interferon Alfa/Monoclonal Antibody CC49	NCIT_C15619
Edetate Calcium Disodium	NCIT_C334	[Contracted name for a salt of ethylenediaminetetraacetate, an agent used as a chelator of lead and some other heavy metals. C10H12CaN2Na2O8.]
Antibiotic Therapy	NCIT_C15620	[Treatment of bacterial infections with antibiotics.]
Infection Prophylaxis and Management	NCIT_C15511	[Treat infections with antibacterial, antifungal, antiparasite or antiviral drugs]
H2 Receptor Antagonist Therapy	NCIT_C15621
Radioimmunoguided Surgery	NCIT_C15622	[Radioguided surgery is an innovative means by which a radionuclide is used to preoperatively image and intraoperatively visualize a structure of interest to the surgeon for excisional biopsy. This technology has allowed a cost-effective, highly specific means by which to locate a structure (usually a lymph node) and access it for pathologic analysis. The result of radioguided surgery is increased specificity in tissue obtained for biopsy, minimal access incisions, and the reduction of inpatient hospital utilization. (from Medscape)]
Image-Guided Therapy	NCIT_C16185	[The use of imaging techniques to provide the basis for therapy, e.g., enabling surgeons to visualize internal structures through an automated overlay of 3D reconstructions of internal anatomy on top of live video views of a patient. Also used for guidance of biopsy needles.]
Intraoperative Radiation Therapy	NCIT_C15623	[The use of any form of radiation therapy during a surgical procedure.]
Local Therapy	NCIT_C15687	[Any therapeutic procedure that targets, or is restricted to, a specific anatomical location.]