Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Cell Migration Inhibition Process	NCIT_C40746	[Cell Migration Inhibition involves interference with, or restraint of, active directed translocation of a whole cell, or cell body, from one site to another in response to a gradient. (NCI)]
Immunogenicity Specimen Assessments Domain	NCIT_C112320	[A findings about domain for submitting dermal responses to antigens.]
Autologous CISH-inactivated TILs	NCIT_C151926	[A preparation of autologous tumor-infiltrating lymphocytes (TILs) where the cytokine-inducible SH2-containing protein gene (CISH) has been inactivated using the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR associated protein 9 (Cas9) editing system, containing guide RNA (gRNA) coupled to a recombinant form of the DNA endonuclease Cas9, with potential immunomodulating and antineoplastic activities. Using the CRISPR/Cas9 system, the autologous TILs are transfected, ex vivo, with a plasmid encoding for a gRNA that site-specifically targets and binds to the human CISH gene. Cas9 cleaves these specific DNA sites, which causes double strand breaks, disrupts the gene encoding CISH and prevents transcription. Upon intravenous administration, the autologous CISH-inactivated TILs are able to induce a T-cell-mediated immune response against tumor cells. CISH, a member of the suppressor of cytokine signaling family (SOCS; cytokine-induced STAT inhibitor; STAT-induced STAT inhibitor; SSI), is induced by T-cell receptor (TCR) stimulation. CISH plays a key role in the negative regulation of both T-cell signaling and CTL-mediated tumor cell eradication. The knockout of the CISH gene enhances the expansion and anti-tumor activities of effector T-cells.]
Recombinant Human IL-7-Hybrid Fc NT-I7	NCIT_C151927	[A long-acting immunoglobulin (Ig) fusion protein composed of a recombinant form of the endogenous human protein interleukin-7 (rhIL-7) and fused to a hybrid Fc (hyFc) region of a human antibody, with hematopoietic and immunopotentiating activities. Upon administration of recombinant human IL-7-hyFc NT-I7, IL-7 stimulates the proliferation, differentiation, trafficking and survival of a variety of T-cell subsets, including naive, central memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA) and natural killer (NK) T-cells, and enhances T-cell-mediated anti-tumor immune responses. Compared to rhIL-7 alone, fusion to the hyFc region enhances the half-life of IL-7. The hyFc region is composed of the hinge and N-terminal portion of heavy chain constant (CH) region 2 (hinge-CH2) of human IgD, which is fused to the C-terminal region of CH2 and the entire CH3 region of human IgG4.]
Ankyrin Repeat Domain-Containing Protein 26	NCIT_C151928	[Ankyrin repeat domain-containing protein 26 (1709 aa, ~196 kDa) is encoded by the human ANKRD26 gene. This protein plays a role in appetite, platelet functions and adipogenesis.]
Ankyrin Repeat	NCIT_C14100	[Ankyrin Repeats are tandem modules of about 33 amino acids. The conserved domain structure has been described as side-by-side anti-parallel alpha helices connected by intervening beta hairpin motifs or as beta, alpha, alpha, beta secondary structures or as an L-shaped beta-hairpin and two alpha-helices. The repeats associate to form a higher order structure. Despite sequence variation, the domain core maintains a stable surface of contact residues to mediate protein-protein interactions. Target protein binding involves contacts by the beta hairpin tips and the helical bundle surface facing the Ankyrin groove. ANK repeats have been identified in over 1700 functionally diverse proteins, primarily from eukaryotes; no common theme among the protein targets has been identified. The Ankyrin cytoskeletal protein is composed almost entirely of these repeats.]
ANKRD26 Gene	NCIT_C151924	[This gene plays a role in platelet functions, adipogenesis and appetite.]
Adipogenesis	NCIT_C20906	[The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat.]
Appetite	NCIT_C25152	[The natural recurring desire for food.]
Cinobufotalin	NCIT_C151929	[A bufadienolide isolated from toad venom and utilized in traditional Chinese medicine (TCM) for its cardiotonic, diuretic and hemostatic effects, with potential cytotoxic and antineoplastic activities. Upon administration and although the exact mechanism of action(s) (MoAs) through which this agent exerts its effects have yet to be fully discovered, cinobufotalin causes DNA fragmentation, decreases mitochondrial membrane potential (MMP), increases intracellular calcium (Ca2+) ion concentrations and reactive oxygen species (ROS) production, upregulates Fas protein and activates cytochrome C, various caspases, Bid and Bax. This causes cell cycle arrest, induces apoptosis and inhibits tumor cell growth and survival. In addition, cinobufotalin inhibits the activity of sphingosine kinase 1 (SphK1) and induces pro-apoptotic ceramide production, which further promotes tumor cell apoptosis. Cinobufotalin also induces mitochondrial protein cyclophilin D (Cyp-D)-dependent opening of the mitochondrial permeability transition pore (mPTP), which may contribute to cinobufotalin-induced non-apoptotic death of certain tumor cells.]
CD46 Gene	NCIT_C126977	[This gene is involved in fertilization, pathogen binding, complement activation and T-regulatory cell differentiation.]
Immunoregulation	NCIT_C18095	[Physiologic control of immune function. Includes all levels of regulation from gene expression mechanisms, through cell-cell interactions, to organism-wide responses.]
Myeloid Neoplasms with Germline Predisposition Associated with Inherited Bone Marrow Failure Syndromes	NCIT_C151922	[Familial myelodysplastic syndromes/ acute myeloid leukemias associated with inherited bone marrow failure syndromes.]
Myeloid Neoplasms with Germline Predisposition Associated with Other Organ Dysfunction	NCIT_C151910	[Familial myeloid neoplasms associated with germline mutations and a preexisting disorder or organ dysfunction other than a platelet disorder.]
CD46 wt Allele	NCIT_C126978	[Human CD46 wild-type allele is located in the vicinity of 1q32 and is approximately 43 kb in length. This allele, which encodes membrane cofactor protein, plays a role in the stimulation of T-regulatory cell differentiation, oocyte fertilization, the classical complement pathway and pathogen binding. Mutation of the gene is associated with increased susceptibility to hemolytic uremic syndrome.]
Complement and Coagulation Cascade	NCIT_C91511
1q32	NCIT_C13881	[A chromosome band present on 1q]
Membrane Cofactor Protein	NCIT_C126979	[Membrane cofactor protein (392 aa, ~44 kDa) is encoded by the human CD46 gene. This protein is involved in the classical complementation pathway, pathogen binding, fertilization and T-cell differentiation.]
Myeloid Neoplasms with Germline ANKRD26 Mutation	NCIT_C151908	[An autosomal dominant disorder characterized by moderate thrombocytopenia and increased risk of developing myelodysplastic syndrome/acute myeloid leukemia. This disorder is characterized by germline mutations in ANKRD26, located on chromosome band 10p12.1. (WHO 2017)]
ANKRD26 wt Allele	NCIT_C151925	[Human ANKRD26 wild-type allele is located in the vicinity of 10p12.1 and is approximately 134 kb in length. This allele, which encodes ankyrin repeat domain-containing protein 26, is involved in adipogenesis, appetite and platelet functions. Mutations in the 5' promoter region of this gene that result in increased expression are associated with autosomal dominant thrombocytopenia 2.]