Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Diffuse Glomerulonephritis	NCIT_C35799	[Inflammation of the glomeruli, in which all glomeruli are affected, resulting in renal failure.]
Hedgehog Inhibitor IPI-609	NCIT_C60772	[A novel proprietary small molecule, and a selective inhibitor of sonic hedgehog signaling pathway, with potential anti-tumor activity. The hedgehog signaling pathway is normally active during neuronal development in embryos and quiescent in adult cells. However, aberrant activation of the hedgehog pathway in adults has been implicated in many cancers, including cancers of the pancreas, prostate, lung (small cell), and brain (glioma). IPI-609 exerts its effect through inhibiting the hedgehog signaling pathway and thereby alters gene expressions of the cancer cells.]
Signal Transduction Inhibitor	NCIT_C2189	[A substance that inhibits kinase enzymes and other proteins involved in signal transduction pathways to prevent tumor cell growth and induce apoptosis.]
Isosorbide	NCIT_C60773	[An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2+. In turn, free Ca+ triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.]
Vasodilating Agent	NCIT_C29707	[Any agent that causes widening of blood vessels as a result of smooth muscle relaxation.]
Pelareorep	NCIT_C60774	[An isolate of the oncolytic, human wild-type serotype 3 Dearing (T3D) strain of the double-stranded RNA virus reovirus (Respiratory Enteric Orphan virus), with potential oncolytic activity. Upon administration, pelareorep is able to replicate specifically in cancer cells bearing an activated Ras pathway. This induces apoptosis in Ras-activated tumor cells and subsequently frees progeny viral particles to infect, replicate in and induce cell death of surrounding cancer cells. In addition, viral replication causes the activation of innate and adaptive immune responses, causing a natural killer (NK)-cell-mediated and a cytotoxic T-cell (CTL)-mediated killing of tumor cells, respectively. Ras-activated tumor cells are deficient in their ability to trigger the antiviral response mediated by the host cellular protein, double-stranded RNA-dependent protein kinase (PKR).]
Oncolytic Virus	NCIT_C717	[Manipulated or engineered viruses having oncolytic properties to selectively replicate in and kill targeted cancer cells, leaving normal cells unharmed.]
Daniplestim	NCIT_C60775	[A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater biological activity than recombinant human IL-3 in human hematopoietic cell proliferation and marrow colony-forming-unit assays. In contrast, this agent shows no significant increase in pro-inflammatory activity relative to native IL-3. The enhanced hematopoietic activity of daniplestim correlates with a 60-fold increase in IL-3 alpha-subunit binding affinity and 20-fold greater affinity for binding to alpha/beta receptor complexes on intact cells relative to recombinant IL-3.]
Recombinant Interleukin	NCIT_C593	[Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins. Produced by T cells, macrophages, and other cells, interleukins bind to a specific surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic effects including stimulation of growth, differentiation, and proliferation of lymphocytes and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell activity; activation of the acute phase response; and stimulation of hematopoiesis. Some interleukins may enhance the host's immune response to malignant cells by stimulating lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL), which are capable of lysing some tumor cells. (NCI04)]
Obatoclax	NCIT_C60770	[A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously.]
Antineoplastic Agent	NCIT_C274	[A substance that inhibits the maturation, growth or spread of tumor cells.]
Hectoliter	NCIT_C69106	[A non-SI unit of volume equal to 100 liters.]
Millimeter of Water Column	NCIT_C69107	[A non-SI manometric unit of pressure defined by a column of water at 4 degrees Celsius with a height of one millimeter.]
Manometric Unit of Pressure	NCIT_C67332
Half Hour	NCIT_C69108	[A unit of time is equal to 0.5 hour or 30 minutes.]
Unit of Time	NCIT_C42574	[An indication of the type of unit of measure being used to express a time.]
Keg	NCIT_C69109	[A traditional unit of volume, significantly varying depending on an item being measured.]
Immune Function, System	NCIT_C21168
Contact Information	NCIT_C60776	[Information regarding the means of contacting a person or group.]
Information	NCIT_C48191	[Knowledge derived from study, experience, or instruction that has been gathered or received by communication.]