Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Adult Lymphocyte-Rich Classic Hodgkin Lymphoma	NCIT_C7223	[Lymphocyte-rich classic Hodgkin lymphoma that occurs in adults.]
Lymphocyte-Rich Classic Hodgkin Lymphoma	NCIT_C6913	[A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, 2008)]
Grade 5 Pharyngeal Stenosis, CTCAE	NCIT_C146490	[Death]
Pharyngeal Stenosis, CTCAE	NCIT_C143757	[A disorder characterized by a narrowing of the pharyngeal airway.]
Plasmablastic Lymphoma	NCIT_C7224	[An aggressive diffuse large B-cell lymphoma frequently arising in the setting of HIV infection and characterized by the presence of large neoplastic cells resembling B-immunoblasts which have the immunophenotypic profile of plasma cells. Sites of involvement include the oral cavity, sinonasal cavity, skin, soft tissues, gastrointestinal tract, and bone.]
Grade 5 Pharyngitis, CTCAE	NCIT_C146491	[Death]
Pharyngitis, CTCAE	NCIT_C143758	[A disorder characterized by inflammation of the throat.]
ALK-Positive Large B-Cell Lymphoma	NCIT_C7225	[A usually aggressive large B-cell lymphoma characterized by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack the 2;5 translocation.]
Grade 5 Phlebitis Infective, CTCAE	NCIT_C146492	[Death]
Phlebitis Infective, CTCAE	NCIT_C143760	[A disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.]
Adult T Lymphoblastic Lymphoma	NCIT_C7226	[T Lymphoblastic lymphoma occurring in adults.]
Grade 5 Pleural Effusion, CTCAE	NCIT_C146493	[Death]
Pleural Effusion, CTCAE	NCIT_C143765	[A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.]
Benzo[b]fluoranthene	NCIT_C29810	[A colorless, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete burning of organic matter. Benzo(b)fluoranthene is primarily found in gasoline exhaust, tobacco and cigarette smoke, coal tar, soot, amino acids and fatty acid pyrolysis products. This substance is used only for research purposes. Benzo(b)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05)]
Benzotrichloride	NCIT_C29811	[An oily, unstable, colorless, chlorinated hydrocarbon with a penetrating odor. Benzotrichloride is used extensively as a chemical intermediate in industry for the preparation of dyes. Its derivatives are used as UV stabilizers in plastic and to manufacture antiseptics and antimicrobial agents. In the presence of moisture, its hydrolyzed vapors (benzoic acid and hydrochloric acid) are highly irritating to the skin and mucous membranes in humans. Benzotrichloride is reasonably anticipated to be a human carcinogen. (NCI05)]
Carcinogenic Chlorinated Hydrocarbon	NCIT_C45386	[A hydrocarbon compound consisting of carbons with one or more chloride atom incorporated in its structure that can increase the risk of human cancer. (NCI05)]
Beta-Naphthoflavone	NCIT_C29812	[A polycyclic aromatic hydrocarbon that consists of a flavone group attached to a benzene ring. Beta-naphthoflavone is an inducer of the hepatic cytochrome p450 CYP1A1 and CYP1A2.]
Phase I Enzymes Inhibitor	NCIT_C54629	[Any natural or synthetic substance that inhibits the activity of any phase I metabolic enzyme. The cytochrome P450 (CYP450) mono-oxygenase family of enzymes catalyzes the majority of the phase I reactions. CYP450 enzymes oxidize xenobiotics, especially drugs and carcinogens, as well as certain endogenous substances. This leads to the introduction of a polar functional group to the compound, enhances their water solubility and renal excretion. However, a highly reactive intermediate and more toxic metabolite than the parent molecule may be produced that can potentially react with and damage DNA. The main CYP450 enzymes involved in the activation of carcinogens include CYP1A1, -1A2, -2A6, -2E1 and -3A4. Phase I enzymes inhibitors prevent the biotransformation of many pro-carcinogens to activated mutagens and carcinogens.]
Phase II Enzymes Inducer	NCIT_C54630	[Any natural or synthetic substance that enhances the activity of any phase II metabolic enzymes. Phase II detoxification enzymes, such as glutathione-S-transferase (GST), glucuronyl transferase, acyl transferase, or sulfotransferase, catalyze conjugation reactions of xenobiotics or metabolites formed in phase I reactions. Conjugation reactions greatly enhance polarity of xenobiotics or their metabolites, thereby facilitate their elimination from the body. Phase II conjugation reactions include glucuronidation, methylation, acetylation, and glutathione, sulfate and amino acid conjugation.]
Naphthalene Compound	NCIT_C54679	[A class of compounds with the basic naphthalene structure, an aromatic hydrocarbon compound, consisting of two fused benzene rings.]