Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Breast Cancer Clinical Regional Lymph Nodes TNM Finding v7	NCIT_C88366	[A clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.]
Breast Cancer cN2b TNM Finding v7	NCIT_C88369	[Breast cancer with metastases only in clinically detected ipsilateral internal mammary nodes and in the absence of clinically evident level I, II axillary lymph node metastases. "Clinically detected" is defined as detected by imaging studies (excluding lymphoscintigraphy) or by clinical examination and having characteristics highly suspicious for malignancy or a presumed pathologic macrometastasis based on fine needle aspiration biopsy with cytologic examination. (from AJCC 7th Ed.)]
Breast Cancer cM1 TNM Finding v7	NCIT_C88374	[Breast cancer with distant detectable metastases as determined by classic clinical and radiographic means and/or histologically proven larger than 0.2 mm. (from AJCC 7th Ed.)]
Breast Cancer Clinical Distant Metastasis TNM Finding v7	NCIT_C88371	[A clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.]
Stage I Breast Cancer AJCC v7	NCIT_C88375	[Stage I includes: IA: T1, N0, M0 and IB: (T0, N1mi, M0); (T1, N1mi, M0). T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T0: No evidence of primary tumor. N0: No regional lymph node metastasis. N1mi: Nodal micrometastases. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+). (AJCC 7th Ed.)]
Breast Cancer by AJCC v7 Stage	NCIT_C91230	[A term that refers to the staging of breast cancer according to the American Joint Committee on Cancer, 7th edition.]
Stage III Breast Cancer AJCC v7	NCIT_C88376	[Stage III includes: IIIA : (T0, N2, M0); (T1, N2, M0); (T2, N2, M0); (T3, N1, M0); (T3, N2, M0), IIIB: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0), and IIIC: (any T, N3, M0). T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or skin nodules). N2: Metastases in ipsilateral level I, II axillary lymph nodes that are clinically fixed or matted; or in clinically detected ipsilateral internal mammary nodes in the absence of clinically evident axillary lymph node metastases. N3: Metastases in ipsilateral infraclavicular (level III) axillary lymph nodes(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+). (AJCC 7th Ed.)]
Stage IIIC Breast Cancer AJCC v7	NCIT_C88377	[Stage IIIC includes: Any T, N3, M0. N3: Metastases in ipsilateral infraclavicular (level III) axillary lymph nodes(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+). (AJCC 7th Ed.)]
Breast Cancer cN3 TNM Finding v7	NCIT_C88370	[Breast cancer with metastases in ipsilateral infraclavicular (level III) axillary lymph node(s) with or without level I, II axillary lymph node involvement; or in clinically detected ipsilateral internal mammary lymph node(s) with clinically evident level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement. (from AJCC 7th Ed.)]
Breast Cancer Clinical TNM Finding v7	NCIT_C88364	[A clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system. TNM clinical findings are based on information obtained prior to the first definitive treatment through physical examination, diagnostic imaging, endoscopy, biopsy or laboratory testing.]
Breast Cancer cM0(i+) TNM Finding v7	NCIT_C88372	[Breast cancer in which there is no clinical or radiographic evidence of distant metastases, but deposits of molecularly or microscopically detected tumor cells in circulating blood, bone marrow, or other nonregional nodal tissue that are no larger than 0.2 mm in a patient without symptoms or signs of metastases. (from AJCC 7th Ed.)]
Breast Cancer cM0 TNM Finding v7	NCIT_C88373	[Breast cancer in which there is no clinical or radiographic evidence of distant metastases. (from AJCC 7th Ed.)]
CST3 Gene	NCIT_C88356	[This gene is involved in enzyme inhibition.]
Cystatin Family Gene	NCIT_C20727	[Cystatin Family Genes encode (Type 2) Cystatin proteins, secreted, tight, reversible, competitive inhibitors of cysteine proteinases that contain multiple cystatin-like sequences and have 2 intrachain disulfide bonds. Cystatin Superfamily Genes comprise three subfamilies that display structural and/or functional similarities: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. (NCI)]
Age-Related Macular Degeneration	NCIT_C84391	[Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.]
Amyloidosis	NCIT_C2868	[A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.]
CST3 wt Allele	NCIT_C88357	[Human CST3 wild-type allele is located in the vicinity of 20p11.21 and is approximately 4 kb in length. This allele, which encodes cystatin-C protein, plays a role in the regulation of cysteine protease activity. Mutation of the gene is associated with both amyloidosis type 6 and age-related macular degeneration type 11.]
Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v7	NCIT_C88348	[A pathologic finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. The classification is based on axillary lymph node dissection with or without sentinel lymph node biopsy. (partially adapted from AJCC 7th Ed.)]
Cystatin-C	NCIT_C88359	[Cystatin-C (146 aa, ~16 kDa) is encoded by the human CST3 gene. This protein is involved in the inhibition of cysteine proteinases.]
Breast Cancer Clinical Primary Tumor TNM Finding v7	NCIT_C88365	[A clinical finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. The TNM clinical and pathologic primary tumor classifications of breast cancer are the same, regardless of whether they are based on clinical and/or pathologic criteria.]