Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Breast Cancer pN2b TNM Finding v7	NCIT_C88360	[Breast cancer with metastases in clinically detected internal mammary lymph nodes in the absence of axillary lymph node metastases. "Clinically detected" is defined as detected by imaging studies (excluding lymphoscintigraphy) or by clinical examination and having characteristics highly suspicious for malignancy or a presumed pathologic macrometastasis based on fine needle aspiration biopsy with cytologic examination. (from AJCC 7th Ed.)]
Breast Cancer pN3b TNM Finding v7	NCIT_C88362	[Breast cancer with metastases in clinically detected ipsilateral internal mammary lymph nodes in the presence of 1 or more positive axillary lymph nodes; or in more than 3 axillary lymph nodes and in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected. (from AJCC 7th Ed.)]
Breast Cancer pN0 TNM Finding v7	NCIT_C88349	[Breast cancer without histological evidence of regional lymph node involvement. Lymph nodes containing only isolated tumor cell clusters are excluded from the total positive node count for purposes of regional lymph node classification, but should be included in the total number of nodes evaluated. (from AJCC 7th Ed.)]
Dopamine-Somatostatin Chimeric Molecule BIM-23A760	NCIT_C88345	[A chimeric molecule directed against dopamine and somatostatin receptors with potential antineoplastic activity. Combining two pharmacological moieties, a somatostatin analogue and a dopamine agonist, dopamine-somatostatin chimeric molecule BIM-23A760 binds with high affinity to dopamine D2 receptor (D2R) and somatostatin receptor subtype 2 (SSTR2), and to a lesser extent to somatostatin receptor subtype 5 (SSTR5). This agent appears to exert its effect mainly by binding to D2R to activate the ERK1/2 and p38 MAPK pathways, thus inducing apoptosis and inhibiting cellular proliferation in non-functioning pituitary adenoma (NFPA) and neuroendocrine tumors. By binding to SSTR2, this agent may inhibit the secretion of growth hormone (GH) by the pituitary gland.]
FAK Inhibitor GSK2256098	NCIT_C88346	[A focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.]
Breast Cancer Pathologic Primary Tumor TNM Finding v7	NCIT_C88347	[A pathologic finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. The TNM pathologic and clinical primary tumor classifications of breast cancer are the same, regardless of whether they are based on pathologic and/or clinical criteria.]
Breast Cancer pN1 TNM Finding v7	NCIT_C88352	[Breast cancer with micrometastases; or metastases in 1 to 3 axillary lymph nodes; and/or metastases in internal mammary nodes, with the metastases detected by sentinel lymph node biopsy but not clinically detected. "Not clinically detected" is defined by imaging studies (excluding lymphoscintigraphy) or by clinical examination. (from AJCC 7th Ed.)]
Breast Cancer pN1mi TNM Finding v7	NCIT_C88353	[Breast cancer with micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm) (from AJCC 7th Ed.)]
Breast Cancer pN1b TNM Finding v7	NCIT_C88354	[Breast cancer with metastases in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected. "Not clinically detected" is defined by imaging studies (excluding lymphoscintigraphy) or by clinical examination. (from AJCC 7th Ed.)]
Breast Cancer pN1c TNM Finding v7	NCIT_C88355	[Breast cancer with metastases in 1 to 3 axillary lymph nodes and in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected. "Not clinically detected" is defined by imaging studies (excluding lymphoscintigraphy) or by clinical examination. (from AJCC 7th Ed.)]
Breast Cancer pN0(i-) TNM Finding v7	NCIT_C88350	[Breast cancer without histological evidence of regional lymph node involvement, and with negative immunohistochemistry. (from AJCC 7th Ed.)]
Breast Cancer pN0(i+) TNM Finding v7	NCIT_C88351	[Breast cancer with malignant cells in regional lymph node(s) no greater than 0.2 mm (detected by H&E or immunohistochemistry including isolated tumor cell clusters). (from AJCC 7th Ed.)]
Beck Depression Inventory	NCIT_C40438	[A twenty-one question survey completed by a patient, with each answer scored on a scale of 0 to 3, designed to measure presence of depression.]
Ovarian Small Cell Carcinoma, Hypercalcemic Type	NCIT_C40439	[An undifferentiated small cell carcinoma that arises from the ovary and is associated with hypercalcemia. Electron microscopic studies show neurosecretory granules are either absent or, when present, are in small numbers.]
Ovarian Small Cell Carcinoma	NCIT_C27390	[A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type.]
Anti-CD6 Monoclonal Antibody	NCIT_C112886	[Any monoclonal antibody directed against the cell surface glycoprotein CD6, regardless of the antibody type.]
Anti-CD7 Monoclonal Antibody	NCIT_C112887	[Any monoclonal antibody directed against the cell surface glycoprotein CD7, regardless of the antibody type.]
Mesenchymal Cell Neoplasm	NCIT_C7059	[A benign, intermediate, or malignant neoplasm that arises from the mesenchyma-derived cells of the soft tissue or bone. Representative examples include lipoma, leiomyoma, leiomyosarcoma and osteosarcoma.]
Connective and Soft Tissue Neoplasm	NCIT_C3810	[A benign, intermediate, or malignant neoplasm that affects the connective and soft tissue.]
Anti-CD8 Monoclonal Antibody	NCIT_C112888	[Any monoclonal antibody directed against the cell surface glycoprotein CD8, regardless of the antibody type.]