Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Epidermal Growth Factor Superfamily Protein	NCIT_C20970	[Many Epidermal Growth Factor Superfamily Proteins are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. The EGF superfamily is characterized by having at least 6 cysteines residues that form disulphide bonds stacked in a ladder-like arrangement, in the order 1-3, 2-4, 5-6, and which are essential for the stability of the EGF fold. Often arranged as tandem repeats in extracellular proteins, the function of the domains remains unclear, but are thought to perform a structural role.]
P32	NCIT_C29315
GON4L wt Allele	NCIT_C132121	[Human GON4L wild-type allele is located in the vicinity of 1q22 and is approximately 110 kb in length. This allele, which encodes GON-4-like protein, is involved in transcriptional repression.]
1q22	NCIT_C14024	[A chromosome band present on 1q]
Immunoglobulin Gene Rearrangement	NCIT_C20045	[Any process of gene rearrangement that creates a novel junction among the immunoglobuling-coding variable, diversity, joining or constant segments. This process involves sequence recognition, cleavage, excision and ligation by recombinases to create a contiguous protein-coding gene. Immunoglobulin gene rearrangement is involved in generation of antibody diversity.]
Falimarev	NCIT_C29316	[A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen-presenting cells (APC) and may activate a cytotoxic T-cell response against CEA- and MUC-1-expressing tumor cells.]
Recombinant Fowlpox-TRICOM Vaccine	NCIT_C2667	[A vaccine comprised of a recombinant fowlpox virus vector encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM), which may enhance antigen presentation and activate cytotoxic T-cells. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)]
GON-4-Like Protein	NCIT_C132122	[GON-4-like protein (2241 aa, ~249 kDa) is encoded by the human GON4L gene. This protein plays a role in the repression of gene transcription.]
Autoantigen	NCIT_C20972	[An endogenous antigen that stimulates the production of autoantibodies, as in an autoimmune reaction. Autoantigens are proteins, nucleic acids, or complexes of both.]
Inalimarev	NCIT_C29317	[A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.]
Recombinant Vaccinia-TRICOM Vaccine	NCIT_C2685	[A vaccine consisting of recombinant vaccinia virus encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-TRICOM vaccine stimulates the host immune system to mount a non-specific T-cell response. With the addition of a tumor-associated antigen peptide, this vaccine may enhance a tumor-specific immune response.]
POLE2 Gene	NCIT_C132123	[This gene is involved in both chromosomal DNA replication and DNA repair.]
G1/S Transition Checkpoint	NCIT_C19416	[The point in G1 at which cells become committed to enter S phase and initiate DNA replication.]
Amphiphysin	NCIT_C20973	[Amphiphysin (695 aa, ~76 kDa) is encoded by the human AMPH gene. This protein may be involved in both exocytosis and cytoskeletal arrangement.]
PCLUS 3:18MN/PCLUS 6.1:18MN	NCIT_C29318
POLE2 wt Allele	NCIT_C132124	[Human POLE2 wild-type allele is located in the vicinity of 14q21.3 and is approximately 45 kb in length. This allele, which encodes DNA polymerase epsilon subunit 2 protein, plays a role in DNA-dependent replication.]
Oxybutynin Chloride	NCIT_C29308
Gallbladder Pain, CTCAE 5.0	NCIT_C146755	[A disorder characterized by a sensation of marked discomfort in the gallbladder region.]
Hepatobiliary Disorders, CTCAE	NCIT_C143170
Oxycodone	NCIT_C29309	[A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability.]