Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
CTLA-4-directed Probody BMS-986249	NCIT_C146765	[A probody composed of ipilimumab, a recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), linked to a proprietary masking peptide that covers the active antigen-binding site of the antibody through a protease-cleavable linker, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration of CTLA-4-directed probody BMS-986249, the masking peptide is cleaved by tumor-associated proteases upon extravasation into the tumor microenvironment (TME). Protease-mediated removal of the linker enables binding of the unmasked monoclonal antibody moiety to CTLA-4, which is expressed on certain T-cells. This inhibits the CTLA4-mediated downregulation of T-cell activation, and leads to both activation of tumor infiltrating T-effector cells and a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily expressed on activated effector T-cells (Teffs) and regulatory T-cells (Tregs), plays a key role in the inhibition of T-cell activity and downregulation of the immune system. The peptide masking of BMS-986249 minimizes binding to CTLA-4 in normal tissues and may reduce systemic toxicity, when compared to ipilimumab. Tumor-associated proteases are present in high concentrations and aberrantly activated in the TME.]
DNA Polymerase Epsilon Subunit 2	NCIT_C132125	[DNA polymerase epsilon subunit 2 (527 aa, ~60 kDa) is encoded by the human POLE2 gene. This protein is involved in the replication and repair of chromosomal DNA.]
Nasal Wash and Collection	NCIT_C132126	[A method used to collect biological material from within the nasal passages. A saline solution is introduced into the nasal passages, retained briefly, and then expelled.]
GARS Gene	NCIT_C132127	[This gene plays a role in the attachment of glycine to the appropriate tRNA.]
GARS wt Allele	NCIT_C132128	[Human GARS wild-type allele is located in the vicinity of 7p14.3 and is approximately 39 kb in length. This allele, which encodes glycine-tRNA ligase protein, is involved in the synthesis of glycyl-tRNA. Mutation of the gene is associated with type 2D Charcot-Marie-Tooth disease and distal hereditary motor neuropathy, type Va.]
Aminoacyl-tRNA Biosynthesis Pathway	NCIT_C38779
Regulation of Exocytosis	NCIT_C20978	[Regulation of Exocytosis consists of subcellular biochemical pathways and mechanisms that control release of cellular ingredients packaged in membrane-bound vesicles that fuse with the plasma membrane.]
Glycine-tRNA Ligase	NCIT_C132129	[Glycine-tRNA ligase (739 aa, ~83 kDa) is encoded by the human GARS gene. This protein plays a role in tRNA aminoacylation.]
Fatty Acid-Binding Protein, Heart	NCIT_C20974	[Fatty acid-binding protein, heart (133 aa, ~15 kDa) is encoded by the human FABP3 gene. This protein plays a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.]
Oxycodone/Acetaminophen	NCIT_C29311	[A combination preparation of the analgesic and antipyretic acetaminophen and the semisynthetic opioid agonist oxycodone with analgesic and antitussive properties. Acetaminophen exerts its analgesic activity by inhibiting prostaglandin synthesis, while oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids.]
Analgesic Preparation	NCIT_C29631	[Natural or synthetic compound mixtures, Analgesic Preparations relieve pain by altering the perception of nociceptive stimuli without loss of consciousness. Analgesic compounds may act at opioid receptors (morphine-like drugs) or at other central or peripheral sites (non-steroidal anti-inflammatory agents). (NCI04)]
FABP1 Gene	NCIT_C20975	[This gene plays a role in fatty acid metabolism in the liver.]
FABP Family Gene	NCIT_C20735	[These genes encode the intracellular fatty acid-binding proteins (FABPs). Fatty acid metabolism in mammalian cells depends on a flux of fatty acids, between the plasma membrane and mitochondria or peroxisomes for beta-oxidation, and between other cellular organelles for lipid synthesis. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and at least 3 different FABPs play a role as transport vehicles of these hydrophobic compounds throughout the cytoplasm. They may participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. (from LocusLink 2170)]
Fatty Acid Metabolism	NCIT_C26565	[Fatty Acid Metabolism involves cellular biotransforming chemical modifications of fatty acids by enzymatic activity.]
Oxycodone/Rixicodone	NCIT_C29312
FABP4 Gene	NCIT_C20976	[This gene plays a role in the regulation of intracellular transport and in fatty acid metabolism.]
Oxymetazoline Hydrochloride	NCIT_C29313	[The hydrochloride salt form of oxymetazoline, an imidazole derivative with a direct acting sympathomimetic property. Oxymetazoline binds to and activates alpha-2 adrenergic receptors. Upon nasal or ocular administration, oxymetazoline constricts the arterioles in the nose and eye, resulting in decreased nasal and conjunctival congestion, respectively.]
FABP5 Gene	NCIT_C20977	[This gene plays a role in a variety of processes including fatty acid metabolism, uptake, and transport.]
Oxymorphone	NCIT_C29314	[A semisynthetic narcotic analgesic related to hydromorphone and other opiates, Oxymorphone, hydroxy-dihydromorphinone, affects the central nervous system and smooth muscles by activation of specific opiate receptors. Similar to morphine, but more potent and without cough suppressant activity, it is used in treatment of moderate to severe pain, including obstetrical pain, or as an adjunct to anaesthesia. (NCI04)]
GON4L Gene	NCIT_C132120	[This gene may play a role in the negative regulation of gene transcription.]