Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Neck Pain, CTCAE 5.0 | NCIT_C146766 | [A disorder characterized by a sensation of marked discomfort in the neck area.] |
| Osteoporosis, CTCAE 5.0 | NCIT_C146767 | [A disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.] |
| Hemoglobinuria, CTCAE 5.0 | NCIT_C146768 | [A disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.] |
| Ovulation Pain, CTCAE 5.0 | NCIT_C146769 | [A disorder characterized by a sensation of marked discomfort in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.] |
| Reproductive System and Breast Disorders, CTCAE | NCIT_C143180 | |
| CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes | NCIT_C107190 | [Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.] |
| EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes | NCIT_C107191 | [Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis.] |
| Distress over Physical Problem with Changes in Urination | NCIT_C107192 | [A question about an individual's distress related to their physical problems with changes in urination.] |
| Distress over Physical Problem with Constipation | NCIT_C107193 | [A question about an individual's distress related to their physical problems with constipation.] |
| Distress over Physical Problem with Diarrhea | NCIT_C107194 | [A question about an individual's distress related to their physical problems with diarrhea.] |
| Distress over Physical Problem with Eating | NCIT_C107195 | [A question about an individual's distress related to their physical problems with eating.] |
| Distress over Physical Problem with Fatigue | NCIT_C107196 | [A question about an individual's distress related to their physical problems with fatigue.] |
| Joint Effusion, CTCAE 5.0 | NCIT_C146760 | [A disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.] |
| Distress over Physical Problem with Feeling Swollen | NCIT_C107197 | [A question about an individual's distress related to their physical problems with feeling swollen.] |
| Lip Pain, CTCAE 5.0 | NCIT_C146761 | [A disorder characterized by a sensation of marked discomfort of the lip.] |
| Distress over Physical Problem with Fevers | NCIT_C107198 | [A question about an individual's distress related to their physical problems with fevers.] |
| Anti-ICOS Agonist Monoclonal Antibody BMS-986226 | NCIT_C146762 | [An agonistic monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS; CD278), with potential immunomodulating and antineoplastic activities. Upon administration, anti-ICOS agonist monoclonal antibody BMS-986226 targets and binds to ICOS expressed on certain T-cells. This stimulates ICOS-mediated signaling, induces proliferation of ICOS-positive T-cells, enhances cytotoxic T-lymphocyte (CTL) survival and augments the CTL-mediated immune response against tumor cells. ICOS, a T-cell specific, CD28-superfamily co-stimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T-cells and plays a key role in the proliferation and activation of T-cells.] |
| Distress over Physical Problem with Getting Around | NCIT_C107199 | [A question about an individual's distress related to their physical problems with getting around.] |
| Memory Impairment, CTCAE 5.0 | NCIT_C146763 | [A disorder characterized by a deterioration in memory function.] |
| Nausea, CTCAE 5.0 | NCIT_C146764 | [A disorder characterized by a queasy sensation and/or the urge to vomit.] |