Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
HRK Protein	NCIT_C20963
Opium Tincture	NCIT_C29300	[Also known as Laudanum and formulated for oral administration, Opium tincture is made of air-dried poppy (Papaver somniferum) latex and contains alkaloids such as morphine and codeine. As an antidiarrheal agent, it slows transit of intestinal contents by increasing intestinal smooth muscle tone and inhibiting motility; water is absorbed from fecal contents, decreasing diarrhea. (NCI04)]
CHRM1 Gene	NCIT_C20964	[This gene is involved in G protein-coupled receptor signal transduction that is elicited by acetylcholine interactions.]
Muscarinic Acetylcholine Receptor M1	NCIT_C20965	[Muscarinic acetylcholine receptor M1 (460 aa, ~51 kDa) is encoded by the human CHRM1 gene. This protein is involved in synaptic transmisssion and G protein-coupled receptor signaling.]
Ophthalmic Solution	NCIT_C29302	[A sterile solution containing a particular pharmaceutical agent administered to the external eye, usually in the form of droplets. An ophthalmic solution may contain different drugs with different mechanisms of actions, to target symptoms and their underlying cause. Classes of pharmacological agents used include antibiotics, beta-adrenergic agents, antihistamines, corticosteroids and prostanoids. The ophthalmic solution can be used to treat increased intraocular pressure, symptoms of allergic conjunctivitis, and ocular bacterial infections.]
CHRM3 Gene	NCIT_C20966	[This gene plays a role in the regulation of smooth muscle contraction and glandular tissue secretions.]
Orlistat	NCIT_C29303	[A reversible active-site inhibitor of gastrointestinal lipases. Orlistat forms a covalent bond with the active serine site in gastric and pancreatic lipases, thereby inhibiting their activity and preventing dietary fat from being hydrolyzed and absorbed. (NCI04)]
Ethinyl Estradiol/Norgestimate	NCIT_C29304	[An oral preparation combination containing the semisynthetic estrogen ethinyl estradiol and the synthetic progestagen norgestimate with contraceptive activity. Ethinyl estradiol and norgestimate act by negative feed back mechanism at pituitary gland suppressing the release of gonadotropin hormones follicle stimulating hormone (FSH) and luteinizing hormone (LH). This combination inhibits ovulation and promotes the thickening of the cervical mucus and the endometrium. The combination of ethinyl estradiol and norgestimate may also be used in the treatment of acne.]
Oral Contraceptive Preparation	NCIT_C29640	[Orally administered synthetic sex hormones with contraceptive activity. The oral contraceptive preparation contains a combination of an estrogen, such as ethinyl estradiol, and a progestagen, such as levonorgestrel or norethidrone. The oral contraceptive prevents pregnancy by preventing ovulation and by inducing endometrial and cervical changes undesirable for fertilization and implantation.]
t(11;12)(p15;p13)	NCIT_C132110	[A cytogenetic abnormality that refers to the translocation of chromosome 11p15 with chromosome 12p13. It results in NUP98-KDM5A fusion and is associated with acute megakaryoblastic leukemia in childhood.]
Chromosome 12	NCIT_C13207	[The designation for each member of the twelfth largest human autosomal chromosome pair. Chromosome 12 spans about 143 million base pairs and represents between 4 and 4.5% of the total DNA in normal diploid cells.]
Oseltamivir Phosphate	NCIT_C29305	[The phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles.]
Acute Megakaryoblastic Leukemia with NUP98-KDM5A	NCIT_C132111	[A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with t(11;12)(p15;p13) which results in the presence of NUP98-KDM5A chimeric oncogene.]
Childhood Acute Myeloid Leukemia with NUP98 Rearrangement	NCIT_C122691	[An acute myeloid leukemia that occurs in childhood and is characterized by the rearrangement of the NUP98 gene.]
M-Phase Inducer Phosphatase 1	NCIT_C20961	[M-phase inducer phosphatase 1 (524 aa, ~59 kDa) is encoded by the human CDC25A gene. This protein plays a role in the regulation of both mitosis and protein phosphorylation.]
Protein Tyrosine Phosphatase	NCIT_C17444	[Encoded by Protein Tyrosine Phosphatase Genes, Protein Tyrosine Phosphatases are a group of enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)]
Oxandrolone	NCIT_C29306	[A synthetic, anabolic steroid hormone analog of testosterone. Similar to testosterone, oxandrolone binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)]
Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522	NCIT_C132112	[An antibody-drug conjugate (ADC) composed of HT-19, a monoclonal antibody directed against the human epidermal growth factor receptor 2 (ERBB2; HER2), conjugated, via a proprietary biodegradable, hydrophilic polymer backbone and various linkers, to proprietary auristatin-derived payload molecules (about 15 per antibody), with potential antineoplastic activity. Upon administration of anti-HER2/auristatin payload ADC XMT-1522, the antibody moiety targets and binds to a unique epitope in the extracellular domain (ECD) of HER2. Upon internalization, cleavage and release of the cytotoxic molecules, the auristatin-derived molecules bind to tubulin and inhibit its polymerization, which results in G2/M phase arrest and induces apoptosis of HER2-expressing tumor cells. The attachment of multiple auristatin molecules to the backbone enables XMT-1522 to effectively kill tumors that express relatively low amounts of the HER2 protein; therefore, this agent shows increased therapeutic potential in tumors with low HER2 expression compared to other anti-HER2 antibody-based therapies. The polymer-based proprietary platform optimizes delivery of the cytotoxic drug payload and improves drug solubility.]
MCL-1 Protien	NCIT_C20962
Oxaprozin	NCIT_C29307	[A nonsteroidal anti-inflammatory drug (NSAID) derivative of oxazole-propionic acid with analgesic and antipyretic properties. As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. When inhibiting COX-2, this agent may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. (NCI04)]