Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
CTNNB1 Gene	NCIT_C20987	[This gene is involved in signal transduction and regulation of transcription.]
Lung Fetal Adenocarcinoma	NCIT_C45509	[A rare morphologic variant of lung adenocarcinoma characterized by the presence of glandular structures containing glycogen-rich cells forming tubules that resemble fetal lung tubules.]
Non-Functioning Adrenal Cortex Adenoma	NCIT_C48458	[An adenoma of the adrenal cortex characterized by the absence of a hormonal syndrome or symptoms suggestive of adrenal disease.]
Adrenal Cortex Carcinoma	NCIT_C9325	[A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.]
Solid Pseudopapillary Neoplasm of the Pancreas	NCIT_C37212	[A low-grade malignant neoplasm that arises from the exocrine pancreas. It is characterized by the presence of uniform cells that form solid and pseudopapillary patterns, cystic changes, and hemorrhage. Perineural invasion, vascular invasion, and invasion into surrounding tissues may be present. It usually presents as an encapsulated, solitary, and lobulated pancreatic mass. It is usually found incidentally during physical examination or it may present with abdominal discomfort and pain. It occurs predominantly in young women. Complete removal of the tumor is curative in the majority of cases.]
Adamantinomatous Craniopharyngioma	NCIT_C4726	[A craniopharyngioma consisting of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO)]
Beta-Catenin-Activated Hepatocellular Adenoma	NCIT_C96759	[A hepatocellular adenoma caused by activating mutations of beta-catenin. It is characterized by the presence of nuclear atypia and absence of inflammation or steatosis. There is an increased risk of malignant transformation.]
Ovarian Endometrioid Adenocarcinoma	NCIT_C7979	[An endometrioid adenocarcinoma arising from the ovary. It comprises 10% to 25% of all primary ovarian carcinomas. Grossly, endometrioid carcinoma may present as a cystic or solid mass. Microscopically, the tumor greatly resembles the appearance of the ordinary type of endometrial adenocarcinoma. As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma.]
CTNNB1 Gene Mutation	NCIT_C36659	[A change in the nucleotide sequence of the CTNNB1 gene.]
Phyllanthoside	NCIT_C29324
Glycoside	NCIT_C66894	[Any compound in which a sugar group is covalently bonded through its anomeric carbon to another group via an O-glycosidic bond or an S-glycosidic bond; glycosides involving the latter are also called thioglycosides. However, substances containing N-glycosidic bonds, where the anomeric carbon is bound to some other group via a nitrogen atom, are called glycosylamines; the term "N-glycoside" is considered a misnomer by IUPAC and is discouraged. Furthermore, the sugar group needs to be bonded to a non-sugar for the molecule to qualify as a glycoside, thus excluding the polysaccharides. The sugar group in glycosides is known as the glycone, which can be a single sugar group (monosaccharide) or several sugar groups (oligosaccharide); the non-sugar group is known as the aglycone or genin.]
Tapentadol Hydrochloride	NCIT_C68922	[An orally active, extended-release preparation of the hydrochloride salt of tapentadol with analgesic activity. Tapentadol is a synthetic, centrally acting analgesic with a dual mechanism of action involving mu-opioid receptor agonism and norepinephrine reuptake inhibition. This agent may be effective in the management of pain, cancer-related and other.]
Physiotherapy	NCIT_C20981
Cobimetinib	NCIT_C68923	[An orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.]
PIXY	NCIT_C29326
Tumor Suppressor Protein	NCIT_C20982	[Proteins involved in the regulation of cell growth and prevention of uncontrolled cell growth.]
Oral Picoplatin	NCIT_C68924	[An oral preparation of picoplatin, a third generation platinum compound with antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and RNA transcription and the induction of apoptosis. Because of the increase in steric bulk around the platinum center, there is a relative reduction in the inactivation of picoplatin by thiol-containing species such as glutathione and metallothionein in comparison to cisplatin.]
Platinum Compound	NCIT_C1450	[A chemotherapy compound that contains a platinum atom. Platinum compounds do not contain alkyl groups but do cause DNA crosslinks and adducts similar to alkylating agents. DNA crosslinks and adducts ultimately lead to the induction of apoptosis.]
Serine Hydrolase	NCIT_C20983	[The serine hydrolases encoded by the serine hydrolase gene are a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156 and NCI)]
Serine Hydrolase Gene	NCIT_C20716	[The serine hydrolase genes encode a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156)]