Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Therapeutic Hemin	NCIT_C68925	[A sterile, lyophilized powder of hemin, the Fe3+ oxidation product of heme (Fe2+), derived from processed red blood cells. Therapeutic hemin appears to inhibit delta-aminolevulinic acid (ALA) synthetase, a rate-limiting enzyme in the porphyrin/heme biosynthetic pathway, resulting in inhibition of the hepatic and/or marrow synthesis of porphyrin precursors. The mechanism by which therapeutic hematin produces symptomatic improvement in patients with acute episodes of the hepatic porphyrias has not been determined.]
PNU-214565	NCIT_C29328	[A recombinant fusion protein of the bacterial superantigen Staphylococcal enterotoxin A (SEA) and the variable Fab fragment of the C242 monoclonal antibody. Upon administering PNU-214565, the Fab fragment binds to Lewis antigen, a glycoprotein overexpressed in human colon and pancreatic carcinoma cell surfaces, thereby directing PNU-214565 to the tumor target area and providing tumor specificity. Superantigen staphylococcal enterotoxin A (SEA) promotes the crosslinking of T-cell receptor (TCR) Vb regions with major histocompatibility complex (MHC) class II molecules on antigen presenting cells, thereby enhancing cytotoxic T-lymphocyte activation, cytokine production and tumor cell lysis.]
Rural-Urban Continuum Code	NCIT_C68926	[A code from a classification scheme that distinguishes metropolitan counties by the population size of their metro area, and nonmetropolitan counties by degree of urbanization and adjacency to a metro area or areas.]
Valacyclovir Hydrolase	NCIT_C20984	[Valacyclovir hydrolase (291 aa, ~33 kDa) is encoded by the human BPHL gene. This protein is involved in the metabolism of both amino acid esters and nucleoside analogues.]
Esterase	NCIT_C16561	[Encoded by Esterase Genes, Esterases catalyze hydrolysis of ester bonds to produce alcohol and acid reaction products. (NCI)]
Purified Protein Derivative	NCIT_C29329	[A purified protein extract derived from the bacterium Mycobacterium tuberculosis. Intradermally-administered, PPD stimulates preprimed CD4 T cells in immunologically competent subjects previously exposed to the bacterium Mycobacterium tuberculosis; these activated CD4 T cells secrete various cytokines that attract granulocytes, monocytes, and macrophages in an inflammatory response known as delayed hypersensitivity. (NCI04)]
Buttock Pain, CTCAE 5.0	NCIT_C146744	[A disorder characterized by a sensation of marked discomfort in the buttocks.]
External Ear Pain, CTCAE 5.0	NCIT_C146745	[A disorder characterized by a sensation of marked discomfort in the external ear region.]
Ear and Labyrinth Disorders, CTCAE	NCIT_C143185
CD22 Gene	NCIT_C20990	[This gene is involved in mediating the adhesion between B cells and is a molecular marker for B-cell precursor acute lymphocytic leukemia.]
Cognitive Disturbance, CTCAE 5.0	NCIT_C146746	[A disorder characterized by a conspicuous change in cognitive function.]
Cancer Pain Group	NCIT_C20991	[Group I: Patients with acute cancer-related pain - associated with diagnosis and/or therapy. Group II: Patients with chronic cancer-related pain - associated with cancer progression and/or therapy. Group III: Patients with preexisting chronic pain and cancer pain. Group IV: Patients with a history of drug addiction and cancer-related pain. This includes those currently using, in treatment, and former users. Group V: Dying patients with cancer-related pain. (Kanner)]
Dizziness, CTCAE 5.0	NCIT_C146747	[A disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.]
Euphoria, CTCAE 5.0	NCIT_C146748	[A disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.]
Exostosis, CTCAE 5.0	NCIT_C146749	[A disorder characterized by non-neoplastic overgrowth of bone.]
Integrin Alpha-E	NCIT_C107130	[Integrin alpha-E (1179 aa, ~130 kDa) is encoded by the human ITGAE gene. This protein plays a role in cell adhesion and may be involved in activation of intestinal intraepithelial lymphocytes.]
FST Gene	NCIT_C107131	[This gene is involved in the regulation of cell growth.]
FST wt Allele	NCIT_C107132	[Human FST wild-type allele is located in the vicinity of 5q11.2 and is approximately 7 kb in length. This allele, which encodes follistatin protein, plays a role in inhibiting both follicle-stimulating hormone release and activin-mediated cell growth.]
Telangiectasia, CTCAE 5.0	NCIT_C146740	[A disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.]
Follistatin	NCIT_C107133	[Follistatin (344 aa, ~38 kDa) is encoded by the human FST gene. This protein is involved in inhibiting both activin-mediated cell growth and follicle-stimulating hormone release.]