Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
OR51E2 wt Allele	NCIT_C132107	[Human OR51E2 wild-type allele is located in the vicinity of 11p15.4 and is approximately 18 kb in length. This allele, which encodes olfactory receptor 51E2 protein, may be involved in olfaction.]
Olfactory Transduction Pathway	NCIT_C91530
11p15.4	NCIT_C14133	[A chromosome band present on 11p]
PR-52	NCIT_C29330
Olfactory Receptor 51E2	NCIT_C132108	[Olfactory receptor 51E2 (320 aa, ~35 kDa) is encoded by the human OR51E2 gene. This protein may play a role in binding odorant molecules.]
PR18 (ras-12CYS) Peptide	NCIT_C29331	[A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to cysteine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)]
Mutated Ras Peptide	NCIT_C2730	[Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas. Mutation locations are notably at codons 12, 13, and 61. Codon 12 mutations form more than 90% of all Ras mutations in human cancers. Degraded Ras peptides have been shown to stimulate immunogenic response. Various forms of mutated Ras peptides-adjuvant are used as vaccine along with cytokines that could potentially enhance the body's immunological response in many neoplastic conditions. (NCI04)]
Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2	NCIT_C132109	[A non-Down syndrome acute megakaryoblastic leukemia that occurs in childhood. It is associated with CBFA2T3-GLIS2 chimeric oncogene and has an unfavorable prognosis.]
6alpha-Methyl-11-oxoprogesterone	NCIT_C29332	[The basic, partial chemical structure of corticosteroid hormones such as cortisone and aldosterone. (NCI04)]
Category Rating Scale	NCIT_C20996	[A pain rating scale that includes specific pain criteria and self-reported ratings based upon specific diagnoses.]
Prospidium Chloride	NCIT_C29333	[An dispiropiperazine derivative with potential cytostatic, anti-inflammatory and immune-suppressive properties. Although the exact mechanism of action of prospidin is not known, this agent was shown to interact with DNA, disrupting cell cycle at G2 phase, inhibiting phagocytic activity of monocytes and macrophage. Prospidin has good anti-lupus activity due to its immunosuppressive effects and was also used in refractory rheumatoid arthritis as an anti-rheumatic drug. (NCI04)]
DNA Adduct Forming Agent	NCIT_C2163	[An agent capable of attaching to DNA with a covent bond. DNA adduct forming agents cause disruption of DNA replication and mitosis.]
Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968	NCIT_C68930	[A synthetic antisense oligodeoxynucleotide (AS ODN) targeting hypoxia-inducible factor-1alpha (HIF-1alpha) with potential antineoplastic activity. Anti-HIF-1alpha LNA antisense oligonucleotide EZN-2968 hybridizes with HIF-1alpha mRNA and blocks t HIF-1 alpha protein expression, which may result in the inhibition of angiogenesis, the inhibition of tumor cell proliferation, and apoptosis. HIF-1alpha, normally activated in response to hypoxia-induced stress, is a key transcription regulator of a large number of genes important in cellular adaptation to low-oxygen conditions, including angiogenesis, cell proliferation, apoptosis, and cell invasion.]
PECAM1 Gene	NCIT_C20997	[This gene is involved in several cellular processes such as: thrombosis, hemostasis, immunity, and inflammatory responses.]
PROSTVAC-Contaminated W/ BVDV	NCIT_C29334	[A vaccinia virus carrying a copy of the human gene encoding prostate-specific antigen (PSA), contaminated with bovine viral diarrhea virus (BVDV).]
Teglarinad Chloride	NCIT_C68931	[A water-soluble prodrug of a cyanoguanidine compound with potential antineoplastic activity. In vivo, teglarinad chloride is rapidly converted into active drug through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, the active drug appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.]
CEACAM5 Gene	NCIT_C20998	[This gene plays a role in the facilitation of hepatic metastasis.]
CEA Family Gene	NCIT_C25900	[Members of the CEA Family Gene encode the members of the CEA Family Protein, which consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. (From OMIM and NCI)]
Metastasis	NCIT_C19151	[The spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor.]
PS IL-10	NCIT_C29335