Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Adenovirus Encoding Human Aquaporin-1	NCIT_C68932	[A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. Upon transfection of salivary glands, adenovirus encoding human aquaporin-1 (AdhAQP1) directs human aquaporin-1 (hAQP1) expression in the apical and basolateral plasma membranes of salivary secretory cells, which may result in increased saliva production. hAQP1, a water channel protein, is one of several highly conserved water channel proteins that mediate water permeability in cells of water-transporting tissues.]
CD44 Gene	NCIT_C20999	[This gene plays a role in cellular matrix adhesion and in lymphocyte activation.]
CD44 Messenger RNA Overexpression	NCIT_C38175
PS IL-10/Placebo	NCIT_C29336
Clinical Study Element	NCIT_C25759
Aerosol Refill	NCIT_C68933	[A container of medication intended to refill an aerosol dispenser.]
PSA-OP Peptide Vaccine	NCIT_C29337	[A 30-residue prostate specific antigen (PSA) oligoepitope peptide (OP) vaccine with potential antineoplastic activity. PSA-OP peptide vaccine contains the PSA-1 and PSA-3 HLA-A2 epitopes and the PSA-9 HLA-class I-A3 epitope joined by peptide linker sequences. In an animal model, vaccination with this agent has been shown to elicit a cytotoxic T-lymphocyte immune response. (NCI04)]
Aerosol with Adapter	NCIT_C68934
Diagnostic or Prognostic Test	NCIT_C18742	[A test perfomed to identify a disease or make a prediction of the course of the disease.]
PSA:154-163(155L) Peptide Vaccine	NCIT_C29338	[A cancer vaccine comprised of a synthetic peptide with an amino acid sequence corresponding to positions 154-163 of the amino acid sequence for prostate-specific antigen (PSA) with a leucine substitution at position 155. Upon administration, PSA:154-163 (155L) peptide vaccine may elicit a cytotoxic T-cell response against tumor cells that express PSA. (NCI05)]
Aerosol Mist Dosage Form	NCIT_C68935	[A mist that is packaged under pressure and released upon activation of an appropriate valve system.]
ALCAM Gene	NCIT_C20994	[This gene plays a role in cellular adhesion events involving immune cells, such as monocytes and leukocytes.]
C-X-C Motif Chemokine 6	NCIT_C29339	[C-X-C motif chemokine 6 (114 aa, ~12 kDa) is encoded by the human CXCL6 gene. This protein is involved in neutrophil chemotaxis, angiogenesis and anti-bacterial activity.]
Alpha Chemokine	NCIT_C20467	[Members of the Alpha-Chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also CXC-Chemokines. Some members of the subgroup of the human CXC-Chemokines are defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.]
Quizartinib	NCIT_C68936	[An orally available small molecule with potential antineoplastic activity. Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.]
Acute Myeloid Leukemia with t(10;11)(p12;q23); MLL-MLLT10	NCIT_C132101	[A rare acute myeloid leukemia that occurs in childhood. It is characterized by t(10;11)(p12;q23) which results in MLL-MLLT10 fusion. It is associated with an unfavorable prognosis.]
Filanesib	NCIT_C68937	[A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. Filanesib specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.]
Kinesin-Like Protein KIF11	NCIT_C48872	[Kinesin-like protein KIF11 (1056 aa, ~119 kDa) is encoded by the human KIF11 gene. This protein plays a role in the formation of a bipolar spindle during mitosis.]
t(10;11)(p12;q23)	NCIT_C132102	[A cytogenetic abnormality that refers to the translocation of chromosome 10p12 with chromosome 11q23. It is associated with acute myeloid leukemia in childhood.]
11q23 Abnormality	NCIT_C158685	[Any cytogenetic abnormality involving chromosome band 11q23.]