Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Past Seven Days Frequency of Urinary Incontinence	NCIT_C132199	[A question about the frequency of an individual's loss of control of urine (leakage) over the past seven days.]
PORCN wt Allele	NCIT_C132190	[Human PORCN wild-type allele is located in the vicinity of Xp11.23 and is approximately 12 kb in length. This allele, which encodes protein-serine O-palmitoleoyltransferase porcupine protein, plays a role in post-translational modification of Wnt family proteins. Mutation of the gene is associated with focal dermal hypoplasia.]
PORCN Gene	NCIT_C132189	[This gene is involved in the lipidation of Wnt family proteins.]
Xp11.23	NCIT_C13135	[A chromosome band present on Xp]
Protein-Serine O-Palmitoleoyltransferase Porcupine	NCIT_C132191	[Protein-serine O-palmitoleoyltransferase porcupine (461 aa, ~52 kDa) is encoded by the human PORCN gene. This protein is involved in serine palmitoleyation of Wnt family proteins.]
Protease-activated Anti-PD-L1 Antibody Prodrug CX-072	NCIT_C132192	[A recombinant antibody prodrug composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) programmed cell death 1 ligand 1 (PD-L1; B7-H1; CD274) that is linked to a proprietary masking peptide through a protease-cleavable linker on the amino terminus of the light chain domain of the antibody, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the linkage system is stable in the circulation and, upon extravasation into the tumor microenvironment, the peptide mask is cleaved by tumor-associated proteases. These proteases are present in high concentrations and aberrantly activated in the tumor microenvironment, while expressed as inactive forms, at much lower concentrations, in normal, healthy tissue. Protease cleavage of the linker enables binding of the unmasked, fully active monoclonal antibody moiety of CX-072 to PD-L1, which is over expressed on certain cancer cells. This blocks the binding to and activation of its receptor programmed cell death 1 (PD-1) on T-lymphocytes, thereby enhancing the T-cell-mediated anti-tumor immune response and reversing PD-L1/PD-1-mediated T-cell suppression. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. Compared to the unmodified PD-L1 antibody, peptide masking of CX-072 minimizes binding to PD-L1 in normal tissues, thereby decreasing autoimmune-based side effects while retaining anti-tumor activity.]
Feline Lymphoma	NCIT_C132193	[A lymphoma that occurs in cats. It is associated with exposure to feline leukemia virus and feline immunodeficiency virus.]
Feline Experimental Organism Diagnosis	NCIT_C134528	[A condition that is relevant to either disease states or models of disease in cats.]
WNT10B Gene	NCIT_C20905	[This gene plays a role in signal transduction, intercellular communication and adipogenesis. It is involved in the regulation of cell fate and behavior during vertebrate development.]
WNT Family Gene	NCIT_C20100	[WNT Family Genes encode secreted structurally related signaling WNT Family Proteins, implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryonic patterning. (NCI)]
Lipid	NCIT_C616	[A class of hydrocarbon-containing organic compounds. Lipids are insoluble in water but soluble in nonpolar solvents and play important roles in living organisms: these roles include functioning as energy storage molecules, serving as structural components of cell membranes, and constituting important signaling molecules. Lipids can be subdivided into 2 groups: fatty acids and glycerides.]
CC Cytokine Gene	NCIT_C26009	[CC Cytokine Genes encode Beta Chemokines, CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)]
Rheumatoid Arthritis	NCIT_C2884	[A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.]
Psoriasis	NCIT_C3346	[An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.]
TRIM25 Gene	NCIT_C20908	[This gene plays a role in transcription and cellular proliferation. The gene is postulated to mediate estrogen interactions in breast cancer.]
Uterine Swelling	NCIT_C20914	[With a high concentration of estrogen receptors, the uterus is one of the most sensitive tissues to the hormone and demonstrates two basic responses to estrogen: it swells by influx of water into the lumen of the uterus, and it increases in weight by the growth of the endometrial layer.]
Restraining Placental Growth	NCIT_C20901	[Restraining Placental Growth involves mechanisms that impede continued expansion of the placenta.]
SLPI Gene	NCIT_C20902	[This gene is involved in the immune response.]
WNT3 Gene	NCIT_C20903	[This gene plays a role in signal transduction and intercellular communication. It is involved in neural development.]
Malignant Gastric Neoplasm	NCIT_C9331	[A primary or metastatic malignant neoplasm involving the stomach.]