Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Cell Fate Control	NCIT_C26142	[Cell Fate Control involves intercellular, cellular, and intracellular processes that regulate the generally irreversible commitment of a multipotent cell(s) to a specific ensuing cell development lineage among alternate potential lineage options.]
SLC5A5 Gene	NCIT_C20904	[This gene is involved in iodide transport.]
Protein MB21D2	NCIT_C132172	[Protein MB21D2 (491 aa, ~56 kDa) is encoded by the human MB21D2 gene. This protein may play a role in cadherin-dependent cell-cell adhesion.]
Zonula Adherens	NCIT_C13736	[The best understood cell-cell junction required for adhesion between cells in the epithelium. It seals adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. Adherens junctions are located most apically in insect cells and just basal to the tight junction in vertebrate cells. It is formed by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence based on homophilic association between molecules of the transmembrane protein E-cadherin, which is linked on its cytoplasmic side to the actin cytoskeleton via b-catenin (Drosophila Armadillo) and a-catenin. The adherens junctions and associated cytoskeleton form a continuous band (zonula adherens) around the apical circumference of each cell, thus uniting the cells of the epithelium into a coherent sheet.]
MB21D2 Gene	NCIT_C132170	[This gene plays a role in protein-protein interactions.]
Bcr-Abl Kinase Inhibitor K0706	NCIT_C132173	[An orally bioavailable, Bcr-Abl tyrosine kinase inhibitor (TKI), with potential antineoplastic activity. Upon administration, Bcr-Abl kinase inhibitor K0706 selectively targets and binds to the Bcr-Abl fusion oncoprotein, including various Bcr-Abl mutant forms, such as those with the 'gatekeeper' resistance mutation T315I. This inhibits proliferation of Bcr-Abl-expressing tumor cells. The Bcr-Abl fusion protein is an aberrantly activated tyrosine kinase produced by certain leukemia cells. T315I, an amino acid substitution where threonine (T) has been mutated to isoleucine (I) at position 315 in the tyrosine-protein kinase ABL1 portion of the Bcr-Abl fusion protein, plays a key role in resistance to certain chemotherapeutic agents and its expression is associated with poor prognosis.]
SPNS2 Gene	NCIT_C132174	[This gene plays a role in lipid transport.]
ETS-Related Transcription Factor Elf-3	NCIT_C20900	[ETS-related transcription factor Elf-3 (371 aa, ~41 kDa) is encoded by the human ELF3 gene. This protein plays a role in the positive regulation of transcription.]
SPNS2 wt Allele	NCIT_C132175	[Human SPNS2 wild-type allele is located in the vicinity of 17p13.2 and is approximately 41 kb in length. This allele, which encodes protein spinster homolog 2, is involved in sphingolipid transport. Mutation of the gene may be involved in early onset progressive hearing loss.]
17p13.2	NCIT_C13877	[A chromosome band present on 17p]
Protein Spinster Homolog 2	NCIT_C132176	[Protein spinster homolog 2 (549 aa, ~58 kDa) is encoded by the human SPNS2 gene. This protein plays a role in the transport of sphingosine 1-phosphate (S1P).]
BCAR4 Gene	NCIT_C132177	[This gene may involved in breast cancer metastasis and resistance to antiestrogens.]
Metastasis Gene	NCIT_C54444	[Normal genes, that when altered or inappropriately expressed, contribute to the spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another.]
BCAR4 wt Allele	NCIT_C132178	[Human BCAR4 wild-type allele is located in the vicinity of 16p13.13 and is approximately 9 kb in length. This allele, which encodes breast cancer anti-estrogen resistance 4 long non-coding RNA, plays a role in both metastasis and antiestrogen resistance in breast carcinoma. Focal amplification and chromosomal rearrangement involving the gene may be associated with cervical cancer.]
Breast Cancer Anti-Estrogen Resistance 4 Long Non-Coding RNA	NCIT_C132179	[Breast cancer anti-estrogen resistance 4 long non-coding RNA (~1.3 kb) is encoded by the human BCAR4 gene. This non-coding RNA is involved in both metastasis and antiestrogen resistance in breast carcinoma.]
MB21D2 wt Allele	NCIT_C132171	[Human MB21D2 wild-type allele is located in the vicinity of 3q29 and is approximately 121 kb in length. This allele, which encodes protein MB21D2, may be involved in adherens junction functions.]
3q29	NCIT_C25056	[A chromosome band present on 3q]
C-C Motif Chemokine 2	NCIT_C20909	[C-C motif chemokine 2 (99 aa, ~11 kDa) is encoded by the human CCL2 gene. This protein plays a role in monocyte and basophil chemotaxis.]
Beta Chemokine	NCIT_C20476	[Encoded by CC Cytokine Genes, Beta Chemokines are CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)]
SEM1 Gene	NCIT_C20916	[This gene is involved in the ATP-dependent degradation of ubiquitinated proteins.]