Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
VSIG10L wt Allele	NCIT_C132156	[Human VSIG10L wild-type allele is located in the vicinity of 19q13.41 and is approximately 11 kb in length. This allele, which encodes V-set and immunoglobulin domain-containing protein 10-like, may be involved in cell-cell adhesion. Mutation or loss of expression of the gene may be associated with neoplastic or pre-neoplastic diseases.]
19q13.41	NCIT_C24987	[A chromosome band present on 19q]
V-Set and Immunoglobulin-Domain Containing Protein 10-Like	NCIT_C132157	[V-set and immunoglobulin domain-containing protein 10-like (867 aa, ~92 kDa) is encoded by the human VSIG10L gene. This protein may play a role in cell-cell junction formation.]
Immunoglobulin-Like V-Type Domain	NCIT_C25794	[The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately 100 amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. The V-type immunoglobins contain the V regions of the Ig molecule. (From InterPro IPR003596)]
IAP Family Gene	NCIT_C20938	[Mammalian IAP Family Genes encode conserved Inhibitors of Apoptosis Proteins with an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)]
Apoptosis Inhibitor Gene	NCIT_C20347	[Apoptosis Inhibitor Genes encode Apoptosis Inhibitor proteins, which impede the initiation, progress, or rate of apoptosis.]
Ankyrin Repeat and SOCS Box Protein 2	NCIT_C132169	[Ankyrin repeat and SOCS box protein 2 (587 aa, ~65 kDa) is encoded by the human ASB2 gene. This protein is involved in the recognition of substrates by the Elongin-Cullin-SOCS-box protein (ECS) E3 ubiquitin-protein ligase complex.]
RAC-Gamma Serine/Threonine Kinase	NCIT_C20939	[RAC-beta serine/threonine-protein kinase (479 aa, ~56 kDa) is encoded by the human AKT3 gene. This protein plays a role in protein phosphorylation, signal transduction, mitochondrial biogenesis and the regulation of caspase-dependent apoptosis.]
IAP Family Protein	NCIT_C20934	[A family of proteins that are related structurally and functionally and are inhibitors of apoptosis.]
Alpha-1B Adrenergic Receptor	NCIT_C20935	[Alpha-1B adrenergic receptor (520 aa, ~57 kDa) is encoded by the human ADRA1B gene. This protein plays a role in cell signaling, cell proliferation and heart development.]
ADRA1B Gene	NCIT_C20936	[This gene is involved in the induction of neoplastic transformation and receptor signaling.]
AKT3 Gene	NCIT_C20937	[This gene is involved in signal transduction and the inhibition of apoptosis.]
Child-Pugh Class A5	NCIT_C146790	[A total score of 5 for hepatic function, corresponding to class A in the Child-Pugh classification.]
Child-Pugh Class A	NCIT_C113691	[Child-Pugh score indicating one-year survival of 100% in patients with chronic liver disease and cirrhosis. This score is determined by the study of the following five factors: bilirubin, albumin, international normalized ratio, presence and degree of ascites, and presence and degree of encephalopathy.]
Apoptotic Protease-Activating Factor 1	NCIT_C20930	[Apoptotic protease-activating factor 1 (1248 aa, ~142 kDa) is encoded by the human APAF1 gene. This protein plays a role in protein-protein interactions, protein modification and apoptosis induction.]
DINOL Gene	NCIT_C132161	[This gene plays a role in p53-dependent responses to DNA damage.]
Baculoviral IAP Repeat-Containing Protein 2	NCIT_C20931	[Baculoviral IAP repeat-containing protein 2 (618 aa, ~70 kDa) is encoded by the human BIRC2 gene. This protein plays a role in the regulation of apoptosis.]
DINOL wt Allele	NCIT_C132162	[Human DINOL wild-type allele is located in the vicinity of 6p21.2 and is approximately 1 kb in length. This allele, which encodes damage induced long noncoding RNA, plays a role in stabilization of cellular tumor antigen p53.]
6p21.2	NCIT_C13487	[A chromosome band present on 6p]
Adrenergic Receptor	NCIT_C105824	[A family of G protein-coupled receptors that bind catecholamines and play a role in the stimulation of the sympathetic nervous system.]