Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Pyrazole Compound	NCIT_C29396	[A class of heterocyclic organic compounds characterized by a ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions. Derivatives of pyrazole exhibit a variety of pharmacological properties, including anti-inflammatory, anti-psychotic, antibiotic and antineoplastic.]
ACLY wt Allele	NCIT_C107108	[Human ACLY wild-type allele is located in the vicinity of 17q21.2 and is approximately 63 kb in length. This allele, which encodes ATP-citrate synthase protein, plays a role in both acetyl-CoA metabolism and de novo lipid synthesis.]
MTCP1 wt Allele	NCIT_C54331	[Human MTCP1 wild-type allele is located in the vicinity of Xq28 and is approximately 86 kb. This allele, which encodes protein p13 MTCP-1, may be involved in the regulation of the cell cycle. Aberrant expression of the gene is observed in T-cell leukemias bearing a t(X;14) translocation.]
MTCP1 Gene	NCIT_C24617	[This gene plays a role in the proliferation of T cells and is involved in cell cycle regulation.]
ATP-Citrate Synthase	NCIT_C107109	[ATP-citrate synthase (1101 aa, ~121 kDa) is encoded by the human ACLY gene. This protein is involved in both the synthesis of cytosolic acetyl-CoA and the de novo lipid synthesis.]
CD3EAP wt Allele	NCIT_C54332	[Human CD3EAP wild-type allele is located in the vicinity of 19q13.3 and is approximately 5 kb in length. This allele, which encodes DNA-directed RNA polymerase I subunit RPA34, plays a role in the transcription of ribosomal RNA.]
Quinapril Hydrochloride	NCIT_C29398	[The hydrochloride salt form of quinapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.]
ACE Inhibitor	NCIT_C247	[Any substance that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis.]
Quinine Sulfate	NCIT_C29399	[The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)]
Medicated Soap Dosage Form	NCIT_C68952	[A substance composed of active and/or inert ingredient(s) in an anionic surfactant, for cleansing.]
Soap Dosage Form	NCIT_C42983	[An anionic surfactant for cleansing.]
Metastatic Ewing Sarcoma	NCIT_C7807	[Ewing sarcoma which has spread from its original site of growth to another anatomic site.]
Metastatic Sarcoma	NCIT_C152076	[A sarcoma that has spread from its original site of growth to another anatomic site.]
Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	NCIT_C27292	[A small round cell tumor with or without neural differentiation which has spread from its original site of growth to another anatomic site.]
Liquid Soap Dosage Form	NCIT_C68953	[A solution or suspension composed of an anionic surfactant used for cleansing.]
Recurrent Ewing Sarcoma	NCIT_C7808	[Ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy.]
Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor	NCIT_C27898	[The reemergence of a malignant small round cell tumor with or without neural differentiation after a period of remission.]
Dental Cone Dosage Form	NCIT_C68954	[A solid bounded by a circular base converging upon a single vertex and intended for administration to the teeth and gingiva in the oral cavity.]
Cone Dosage Form	NCIT_C42900	[A solid with a shape bounded by a circular base converging upon a single vertex.]
Adult Fibrosarcoma	NCIT_C7809	[A malignant mesenchymal neoplasm composed of fibroblasts. It is characterized by collagen production and a herringbone architectural pattern. It is more commonly seen in middle-aged and older adults. It usually affects the deep soft tissues of extremities, trunk, head and neck. Adult fibrosarcomas may recur and metastasize to the lungs and bones.]