Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Recurrent Anal Canal Carcinoma	NCIT_C7793	[The reemergence of anal carcinoma after a period of remission.]
Anal Canal Carcinoma	NCIT_C7489	[A squamous cell carcinoma or less frequently an adenocarcinoma, often associated with human papillomavirus (HPV) infection. Homosexual men are at particular risk. The most important prognostic factors are tumor stage and nodal status.]
Stage 0 Anal Canal Cancer AJCC v6 and v7	NCIT_C7794	[Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th Eds.)]
Stage I Rectal Cancer AJCC v6 and v7	NCIT_C7790	[Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)]
Rectal Cancer by AJCC v7 Stage	NCIT_C91225	[A term that refers to the staging of rectal carcinoma according to the American Joint Committee on Cancer, 7th edition.]
Stage I Colorectal Cancer AJCC v6 and v7	NCIT_C8513	[Stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)]
Dose Escalation	NCIT_C107213	[A stepwise increase in the amount of a therapeutic or investigational agent given to an individual.]
Cisplatin/Dacarbazine/Interferon-alpha/Tamoxifen/Tumor Infiltrating Lymphocytes	NCIT_C29480
Dacarbazine	NCIT_C411	[A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)]
Tamoxifen Citrate	NCIT_C855	[The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC.]
Cisplatin	NCIT_C376	[An alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition.]
Little Interest or Pleasure in Doing Things	NCIT_C107214	[A question about whether an individual has or had little interest or pleasure in doing things.]
Monoclonal Antibody T101 F(ab)2	NCIT_C29481	[A synthetic mouse monoclonal antibody which targets CD5+ lymphocytes. Monoclonal antibody T101 may be used in the immunotherapy of T-cell malignancies. Containing only the antigen-binding fragment of an immunoglobulin molecule, an FAB (fragment antibody) offers the advantages of smaller size and lower cross-reactivity compared to complete antibodies. (NCI04)]
Poor Appetite or Overeating	NCIT_C107215	[A question about whether an individual has or had a poor appetite or was overeating.]
TNF Transduced TIL	NCIT_C29482	[A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity. Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04)]
Feeling Bad about Yourself or Feeling Like a Failure or Have Let Yourself or Your Family Down	NCIT_C107216	[A question about whether an individual feels or felt bad about oneself or that one is a failure or has let oneself or their family down.]
TGFa-PE38 Immunotoxin	NCIT_C29483	[A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)]
Pseudomonas Exotoxin Immunoconjugate	NCIT_C78532	[An immunotoxin containing epitope of Pseudomonas exotoxin (PE) with immunotherapeutic property. PE, a peptide toxin of 613 amino acids, consists of 3 functional domains: an amino-terminal receptor-binding domain, a middle translocation domain, and a carboxyl-terminal ADP-ribosylation domain. The last 5 carboxyl-terminal amino acids, Arg-Glu-Asp-Leu-Lys, are critical for its cytotoxic action.]
Moving or Speaking So Slowly that Other People Could Have Noticed	NCIT_C107217	[A question about whether an individual has or has been moving or speaking so slowly that other people could have noticed.]
EPS8L1 wt Allele	NCIT_C54440	[Human EPS8L1 wild-type allele is located in the vicinity of 19q13.42 and is approximately 16 kb in length. This allele, which encodes PP10566 protein, plays a role in signal transduction related to actin remodeling.]