Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
EPS8L1 Gene	NCIT_C24371	[This gene plays a role in intercellular communication and may play a role in cell growth.]
Total Parenteral Nutrition	NCIT_C29484	[Total parenteral nutrition formulated for intravenous administration in patients who cannot eat or cannot get enough nutrients from the foods they eat. It is a liquid mixture of proteins, carbohydrates, fats, vitamins, minerals and other nutrients.]
So Fidgety or Restless that You Have Been Moving around More	NCIT_C107218	[A question about whether an individual was being so fidgety or restless that it seemed that one has been moving around more.]
EPS8L2 wt Allele	NCIT_C54441	[Human EPS8L2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 22 kb in length. This allele, which encodes epidermal growth factor receptor kinase substrate 8-like protein 2, plays a role in signal transduction related to actin remodeling.]
EPS8L2 Gene	NCIT_C24372	[This gene plays a role in intercellular communication and may play a role in cell growth.]
Trimelamol	NCIT_C29485	[A synthetic derivative of trimethylmelamine with antineoplastic properties. An analogue of siderophores (microbial iron chelators), trimelamol induces the formation of a reactive iminium species which may crosslink DNA. (NCI04)]
Thoughts You Would be Better Off Dead or Hurting Yourself Some Way	NCIT_C107219	[A question about whether an individual has or had thoughts that one would be better off dead or of hurting oneself in some way.]
EPS8L3 wt Allele	NCIT_C54442	[Human EPS8L3 wild-type allele is located in the vicinity of 1p13.3 and is approximately 14 kb in length. This allele, which encodes EPS8-like 3 protein, is involved in erythroid differentiation and proliferation. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been identified in cases of chronic myeloproliferative disorder.]
EPS8L3 Gene	NCIT_C24373	[This gene plays a role in cancer invasion and metastasis.]
Tamsulosin Hydrochloride	NCIT_C29486	[The hydrochloride salt of tamsulosin, a sulfonamide derivative with adrenergic antagonist activity. Tamsulosin selectivity binds to and blocks the activity of alpha1 adrenoreceptors in the human prostate and bladder neck; blockade of these adrenoceptors can cause smooth muscle in the prostate and bladder neck to relax, resulting in an improvement in urinary flow rate.]
Tazarotene	NCIT_C29487	[A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)]
Oxford Nanopore Sequencing	NCIT_C146818	[A proprietary next-generation DNA sequencing technology from Oxford Nanopore Technologies that can directly identify and sequence a DNA molecule as it passes through a nanopore, driven by electrophoresis.]
Nucleic Acid Sequencing	NCIT_C18881	[The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides.]
Temazepam	NCIT_C29488	[A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.]
SMRT Sequencing	NCIT_C146819	[A proprietary third-generation DNA sequencing system from Pacific Biosciences that uses zero-mode waveguides (ZMWs) and phospholinked nucleotides. A single DNA polymerase enzyme is affixed at the bottom of a ZMW structure with a single molecule of DNA as a template. A fluorescent tag is cleaved off with each base addition and is detected to create the sequence.]
Tenecteplase	NCIT_C29489	[A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.]
Nanoparticle Paclitaxel Ointment SOR007	NCIT_C146821	[A topical ointment composed of the water-insoluble taxane paclitaxel that has been processed to form uncoated nanoparticles, with potential antineoplastic activity. Upon topical administration of nanoparticle paclitaxel ointment SOR007 to the affected area, and following epithelial and dermal penetration, paclitaxel binds to tubulin and inhibits the disassembly of microtubules, which leads to the inhibition of cell division, thereby halting the proliferation of rapidly-dividing tumor cells. The nanoparticles in the nanoparticle paclitaxel ointment are produced through a specific proprietary submicron particle production.]
Nanoparticle Paclitaxel Ointment SOR007	NCIT_C146822	[A topical ointment composed of the water-insoluble taxane paclitaxel that has been processed to form uncoated nanoparticles, with potential antineoplastic activity. Upon topical administration of nanoparticle paclitaxel ointment SOR007 to the affected area, and following epithelial and dermal penetration, paclitaxel binds to tubulin and inhibits the disassembly of microtubules, which leads to the inhibition of cell division, thereby halting the proliferation of rapidly-dividing tumor cells. The nanoparticles in the nanoparticle paclitaxel ointment are produced through a specific proprietary submicron particle production.]
Autologous iCASP9-CD19-expressing T-Lymphocytes	NCIT_C146823	[A preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and the inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunomodulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon intravenous administration, autologous iCASP9-CD19-expressing T-lymphocytes (iC9-CAR19 T-cells) target and bind to CD19-expressing tumor cells, thereby selectively lysing these tumor cells. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered iC9-CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.]
Anti-EGFRvIII/CD3 BiTE Antibody AMG 596	NCIT_C146824	[A proprietary recombinant bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one that is directed against a tumor-associated antigen (TAA), the epidermal growth factor receptor (EGFR) deletion-mutant form, EGFR variant III (EGFRvIII), and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-EGFRvIII/CD3 BiTE antibody AMG 596, the bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and EGFRvIII found on EGFRvIII-expressing tumor cells. This activates and crosslinks CTLs with EGFRvIII-expressing tumor cells, which results in the CTL-mediated cell death of EGFRvIII-expressing tumor cells. EGFRvIII, a mutation in the EGFR gene where exons 2-7 have been deleted, is overexpressed by a variety of cancers, but is absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy.]