Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
BRD4 Inhibitor PLX2853	NCIT_C146825	[An orally bioavailable inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon oral administration, the BRD4 inhibitor PLX2853 binds to the acetylated lysine recognition motifs in the bromodomains of the BRD4 protein, thereby preventing the binding of BRD4 to acetylated lysines on histones. This disrupts chromatin remodeling and dyregulates gene expression. This may lead to the downregulation of the expression of certain growth-promoting genes, which may induce apoptosis and inhibit the proliferation of BRD4-overexpressing tumor cells. BRD4, a member of the human bromodomain and extra-terminal (BET) family of proteins, is a transcriptional regulator that is overexpressed in certain tumor cells and plays an important role in cellular proliferation.]
Mediastinal Germ Cell Tumor M0 TNM Finding	NCIT_C146828	[Mediastinal germ cell tumor without evidence of distant metastasis. (WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart, 2015)]
DLEC1 wt Allele	NCIT_C54432	[Human DLEC1 wild-type allele is located within 3p22-p21.3 and is approximately 261 kb in length. This allele, which encodes deleted in lung and esophageal cancer 1 protein, plays a role in tumor suppression. This allele is frequently deleted or abberantly expressed in several cancers.]
DLEC1 Gene	NCIT_C24340	[This gene may be involved in tumor suppression.]
RSU1 wt Allele	NCIT_C54433	[Human RSU1 wild type allele is located in the vicinity of 10p13 and is approximately 227 kb in length. This allele, which encodes Ras suppressor protein 1, is involved in the modulation of Ras signaling, cellular growth and nerve growth factor induced differentiation.]
DLEU1 wt Allele	NCIT_C54434	[Human DLEU1 wild-type allele is located in the vicinity of 13q14.3 and is approximately 23 kb in length. This allele, which encodes leukemia-associated protein 1, is involved in tumor suppression. Frequently, the allele has been found to be deleted in chronic lymphocytic leukemia.]
DLEU1 Gene	NCIT_C24341	[This gene is involved in tumor suppression pertaining to chronic lymphocytic leukemia.]
DLEU2 wt Allele	NCIT_C54435	[Human DLEU2 wild-type allele is located in the vicinity of 13q14.2 and is approximately 98 kb in length. This allele, which encodes deleted in lymphocytic leukemia 2 non-protein coding RNA, is putatively involved in the inhibition of cancer cell growth. Genetic aberrations involving the gene are associated with B-cell chronic lymphocytic leukemia, mantle-cell lymphoma and multiple myeloma.]
DLEU2 Gene	NCIT_C24342	[This gene may be involved in regulation of cell growth.]
13q14.2	NCIT_C13608	[A chromosome band present on 13q]
13: 49554115-49515574	NCIT_C42136	[Physical location of DLEU2_Gene]
RTN1 wt Allele	NCIT_C54436	[Human RTN1 wild-type allele is located in the vicinity of 14q23.1 and is approximately 275 kb in length. This allele, which encodes reticulon-1 protein, is involved in the mediation of either neuroendocrine hormone secretion or membrane trafficking in neuroendocrine cells.]
CDK2AP2 wt Allele	NCIT_C54437	[Human CDK2AP2 wild-type allele is located within 11q13 and is approximately 2 kb in length. This allele, which encodes cyclin-dependent kinase 2-associated protein 2, plays a role in the regulation of cell cycle, proliferation, and developmental processes.]
CDK2AP2 Gene	NCIT_C24347	[This gene plays a regulatory role in cell cycle events.]
Distress over Other Problem	NCIT_C107210	[A question about an individual's distress related to other problems not included in the list.]
PMEL wt Allele	NCIT_C54438	[Human PMEL wild-type allele is located in the vicnity of 12q13.2 and is approximately 19 kb in length. This allele, which encodes melanocyte protein PMEL, is involved in the regulation of melanosome biogenesis. Elevated expression of the gene is observed in some melanomas.]
PMEL Gene	NCIT_C41033	[This gene plays a role in melanosome biogenesis. It is also involved in T-cell recognition.]
Skin-Sparing Mastectomy	NCIT_C107211	[Removal of the breast tissue, nipple, areola, and original biopsy scar, but not the breast skin.]
EGFL6 wt Allele	NCIT_C54439	[Human EGFL6 wild-type allele is located within Xp22 and is approximately 64 kb in length. This allele, which encodes EGF-Like Protein 6, is involved in cell cycle.]
EGFL6 Gene	NCIT_C24360	[This gene plays a role in cell cycle and may play a role in cell growth.]