Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Anti-SSTR2/CD3 Monoclonal Antibody XmAb18087	NCIT_C146820	[A humanized, Fc domain-containing, bispecific monoclonal antibody targeting human CD3, a T-cell surface antigen, and somatostatin receptor 2 (SSTR2), a tumor-associated antigen (TAA) expressed on certain cancer cells, with potential antineoplastic activity. Upon administration, anti-SSTR2/CD3 monoclonal antibody XmAb18087 binds to both T-cells and SSTR2-expressing cancer cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the SSTR2-expressing cancer cells. The inclusion of an Fc domain on the antibody prolongs the half-life of the bispecific antibody.]
Oncoplastic Partial Mastectomy/Lumpectomy with Oncoplastic Closure	NCIT_C107212	[A surgical procedure in which there is full-thickness excision of the malignant breast tumor and surrounding breast parenchyma to allow resection with wide surgical margins, while the remaining fibroglandular breast tissue is transposed to preserve the breast shape and cosmetic appearance in the best possible way.]
Tenofovir	NCIT_C29490	[A nucleoside reverse transcriptase inhibitor analog of adenosine.]
Purine Antagonist	NCIT_C1556	[An antimetabolite that affects the metabolism and utilization of purines.]
Nucleoside Reverse Transcriptase Inhibitor	NCIT_C97452	[A substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase resulting in inhibition of enzyme function, chain termination, and inhibition of viral replication. These compounds are converted to their active phosphorylated forms by cellular kinases.]
Distress over Physical Problem with Mouth Sores	NCIT_C107202	[A question about an individual's distress related to their physical problems with mouth sores.]
Terazosin Hydrochloride	NCIT_C29491	[The hydrochloride salt form of terazosin, a quinazoline derivative with adrenergic antagonistic property. Terazosin hydrochloride selectively inhibits alpha-1 adrenergic receptors, resulting in vasodilation leading to decreased peripheral vascular resistance and a reduced venous return to the heart as well as decreased urethral resistance, which potentially improving urine flow and symptoms related to benign prostatic hyperplasia. In addition, terazosin decreases low-density lipoproteins (LDL) and triglycerides while increasing the concentration of high-density lipoproteins (HDL).]
Distress over Physical Problem with Nausea	NCIT_C107203	[A question about an individual's distress related to their physical problems with nausea.]
Terbinafine Hydrochloride	NCIT_C29492	[A synthetic allylamine derivative structurally related to naftifine, antifungal Terbinafine Hydrochloride blocks ergosterol biosynthesis by inhibition of squalene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane. Highly lipophilic, it tends to accumulate in skin, nails, and fatty tissues. Terbinafine is active against dermatophytes. (NCI04)]
Distress over Physical Problem with Dry or Congested Nose	NCIT_C107204	[A question about an individual's distress related to their physical problems with nose dryness or congestion.]
Terconazole	NCIT_C29493	[A synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.. (NCI04)]
Distress over Physical Problem with Pain	NCIT_C107205	[A question about an individual's distress related to their physical problems with pain.]
Terfenadine	NCIT_C29494	[A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways.]
Distress over Physical Problem with Sexual Activity	NCIT_C107206	[A question about an individual's distress related to their physical problems with sexual activity.]
Theraflu	NCIT_C29495	[Any of the commercial combination preparations, by Novartis, containing a combination of any of the following agents: the analgesic antipyretic acetaminophen, an antihistamine (chlorpheniramine maleate, diphenhydramine hydrochloride, doxylamine succinate or pheniramine maleate), the antitussive dextromethorphan maleate and/or a decongestant (phenylephrine hydrochloride or pseudoephedrine hydrochloride). Theraflu preparations are used to relieve symptoms of cold and flu. Acetaminophen exerts its actions by inhibiting prostaglandin synthesis. The antihistamines block the effects of histamine. Dextromethorphan exerts its activity by raising the threshold for coughing in the cough center. The decongestants are sympathomimetic agents that cause vasoconstriction mediated through alpha-adrenergic receptors. This reduces blood flow, decreases swelling and prevents nasal and sinus congestion.]
Distress over Physical Problem with Dry or Itchy Skin	NCIT_C107207	[A question about an individual's distress related to their physical problems with skin dryness or itchiness.]
INTS6 wt Allele	NCIT_C54430	[Human INTS6 wild-type allele is located within 13q14.12-q14.2 and is approximately 92 kb in length. This allele, which encodes integrator complex subunit 6 protein, may play a role in the regulation of both small nuclear RNA transcription and RNA polymerase II activity.]
INTS6 Gene	NCIT_C24336	[This gene may play a role in the transcriptional regulation that modulates chondrogenesis.]
13q14.12-q14.2	NCIT_C24945	[A chromosome band present on 13q]
13: 50925135-50837364	NCIT_C42124	[Physical location of DDX26_Gene]