Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Distress over Physical Problem with Sleep	NCIT_C107208	[A question about an individual's distress related to their physical problems with sleep.]
DEC1 wt Allele	NCIT_C54431	[Human DEC1 wild-type allele is located in the vicinity of 9q33.1 and is approximately 261 kb in length. This allele, which encodes protein deleted in esophageal cancer 1 protein, is involved in tumor suppression and putatively cellular proliferation.]
DEC1 Gene	NCIT_C24337	[This gene may play a role in tumor suppression.]
Thiethylperazine Maleate	NCIT_C29497	[The maleate salt form of triethylperazine, a piperazine phenothiazine derivative and a dopamine antagonist used as antiemetic. Thiethylperazine blocks postsynaptic dopamine 2 (D2) receptors in the medullary chemoreceptor trigger zone (CTZ), thereby decreasing stimulation of the vomiting center in the brain. Peripherally, thiethylperazine blocks the vagus nerve in the gastrointestinal tract. In addition, this agent also shows antagonistic activities mediated through muscarinic receptors, H1-receptors, and alpha(1)-receptors.]
Distress over Physical Problem with Tingling in Hands or Feet	NCIT_C107209	[A question about an individual's distress related to their physical problems with tingling in hands or feet.]
Thioridazine Hydrochloride	NCIT_C29498	[The hydrochloride salt form of thioridazine, a piperidine phenothiazine derivative and a dopamine antagonist with antipsychotic property. Thioridazine hydrochloride binds to mesolimbic postsynaptic dopamine receptor D2, thereby decreasing dopamine activity leading to decreased psychotic effects, such as hallucinations and delusions. In addition, this agent binds to serotonin 5-HT2 receptors, resulting in decreased serotonin activity.]
ATR Kinase Inhibitor BAY1895344	NCIT_C146807	[An orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor BAY1895344 selectively binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling. This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and cell survival.]
ATR Inhibitor	NCIT_C155926	[Any agent that inhibits the serine/threonine protein kinase ATR (ataxia telangiectasia; Rad3-related protein).]
Thrombin Alfa	NCIT_C29499	[A recombinant peptide that is chemically identical to or similar to the endogenous thrombin. Thrombin, a serine protease, plays significant roles in the coagulation cascade, such as breaking down soluble fibrinogen to promote fibrin clot formation, as well as activating factor XI, factor V, and factor VIII.]
Anti-IL17A Monoclonal Antibody CJM112	NCIT_C146808	[A human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, anti-IL17A monoclonal antibody CJM112 selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases, such as psoriasis and multiple sclerosis (MS), and plays a key role in the development of inflammation and the immune response.]
454 Sequencing	NCIT_C146809	[A proprietary next-generation DNA sequencing system from 454 Life Sciences that used large-scale parallel pyrosequencing. The system relied on fixing nebulized and adapter-ligated DNA fragments to small DNA-capture beads in a water-in-oil emulsion.]
RNF11 wt Allele	NCIT_C54429	[Human RNF11 wild-type allele is located within 1pter-p22.1 and is approximately 37 kb in length. This allele, which encodes RING finger protein 11, is involved in the transfer of ubiquitin to proteins targeted for degradation. Overexpression of the RNF gene is associated with several types of cancer such as breast and prostate cancer. Certain allelic variants of this gene cause multiple endocrine neoplasias.]
RNF11 Gene	NCIT_C24743	[This gene plays a role in the regulation of protein degradation.]
HER2 Inhibitor TAS0728	NCIT_C146810	[An orally available covalent inhibitor of human epidermal growth factor receptor 2 (HER2; ERBB2), with potential antineoplastic activity. Upon oral administration, HER2 inhibitor TAS0728 specifically and irreversibly binds to and inhibits the activity of HER2. This prevents HER2-mediated signaling and leads to cell death in HER2- and HER3 (ErbB3)-expressing tumor cells. HER2, a receptor tyrosine kinase mutated or overexpressed in many tumor cell types, play key roles in tumor cell proliferation and tumor vascularization. HER3 has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2.]
ABI SOLiD Sequencing	NCIT_C146811	[A proprietary next-generation DNA sequencing system from Applied Biosystems that utilizes DNA ligase. DNA fragments attached to beads are clonally amplified and ligated to fluorescently labeled "interrogation probes". Ligation frees the fluor, which is detected and identifies the specific probe. The marker of the attached probe is then removed and a 5'-phosphate group is regenerated. Multiple cycles of ligation, detection, and cleavage are performed.]
BGISEQ-500 Sequencing	NCIT_C146812	[A proprietary next-generation DNA sequencing system from BGI Genomics using combinatorial Probe-Anchor Synthesis (cPAS) and improved DNA Nanoballs (DNB) technology. The cPAS chemistry works by incorporating a fluorescent probe to a DNA anchor on the DNB, followed by high-resolution digital imaging.]
mRNA-based Personalized Cancer Vaccine mRNA-4157	NCIT_C146813	[An mRNA-based individualized, therapeutic personalized cancer vaccine (PCV) targeting twenty tumor-associated antigens (TAAs) that are specifically expressed by the patient's cancer cells, with potential immunostimulatory and antineoplastic activities. The cells from the patient's tumor are analyzed, and genetic sequencing is used to identify twenty neoantigen epitopes that may elicit the strongest immune response in the patient. The sequences encoding the twenty patient-specific epitopes are transcribed and loaded onto a single mRNA molecule. Upon administration, the mRNA-based PCV mRNA-4157 is taken up and translated by antigen presenting cells (APCs). Then, the expressed epitopes are presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL)- and memory T-cell-dependent immune responses that specifically target and destroy the patient's cancer cells that express these neoantigens.]
Capillary Sequencing	NCIT_C146814	[A DNA sequencing technology that uses a long, thin, acrylic-fiber capillary to size-separate fluorescence-labelled DNA fragments.]
Complete Genomics Sequencing	NCIT_C146815	[A next-generation DNA sequencing service offered by Complete Genomics. Unamplified human genomic DNA is sheared into 500bp fragments and then amplified to create DNA nano-balls (DNBs). The DNBs are arrayed on a substrate and their sequence is determined by Combinatorial Probe-Anchor Ligation (cPAL) sequencing.]
Helicos Sequencing	NCIT_C146816	[A proprietary next-generation DNA sequencing system from Helicos BioSciences based on zero wave guide technology and using unamplified DNA templates that are anchored to the surface of a glass slide. For each nucleotide cycle, polymerases are bound to the immobilized templates, and both fluorescently labeled nucleotides and proprietary terminators, which kinetically inhibit the polymerase from incorporating more than a single base, are added. The slide surface is then imaged with a high-intensity laser and where the fluorescent signal detected indicates a base incorporation at that position in the fluorescing template sequence.]