Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Illumina Sequencing	NCIT_C146817	[A proprietary next-generation DNA sequencing system from Solexa that uses reversible terminator nucleotides. The genomic DNA to be sequenced is fragmented and ligated to adapter molecules on both ends to construct an Illumina-specific adapter library. PCR amplification of the DNA fragments is then performed using the adapter sequence as primer. Sequencing is carried out by repeated cycles of adding reversible fluorescent-labelled nucleotide and incorporation of the nucleotides to the complementary strand. The fluorescence of the incorporated nucleotides is detected.]
PPP3R2 wt Allele	NCIT_C54421	[Human PPP3R2 wild-type allele is located in the vicinity of 9q31.1 and is approximately 3 kb in length. This allele, which encodes calcineurin subunit B isoform 2 protein, plays a role in the dephosphorylation of phosphoproteins during osteoblast differentiation.]
PPP3R2 Gene	NCIT_C38530	[This gene plays a role in calcium-mediated signal transduction.]
PVT1 wt Allele	NCIT_C54422	[Human PVT1 wild-type allele is located in the vicinity of 8q24.21 and is approximately 307 kb in length. This allele, which encodes Pvt1 oncogene long non-coding RNA, may play a role in the regulation of the expression of the MYC gene. Overexpression of the PVT1 gene is associated with the development of Burkitt lymphoma, breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma; variations in this gene are associated with end-stage renal disease attributed to type 1 diabetes.]
PVT1 Gene	NCIT_C18403	[This gene plays a role in the activation of transcription.]
8q24	NCIT_C13591	[A chromosome band present on 8q]
TRIM13 wt Allele	NCIT_C54423	[Human TRIM13 wild-type allele is located within 13q14 and is approximately 21 kb in length. This allele, which encodes tripartite motif-containing protein 13, plays a putative role in the inhibition of cell growth and proliferation. Loss of TRIM13 gene function may be associated with chronic B-cell leukemia.]
TRIM13 Gene	NCIT_C24734	[This gene may be involved in the negative regulation of cell growth.]
PDLIM4 wt Allele	NCIT_C54424	[Human PDLIM4 wild-type allele is located in the vicinity of 5q31.1 and is approximately 16 kb in length. This allele, which encodes PDZ and LIM domain protein 4, may play a role in the modulation of the structure of the actin cytoskeleton.]
CCDC6 wt Allele	NCIT_C54425	[Human CCDC6 wild-type allele is located in the vicinity of chromosome 10q21.2 and is approximately 118 kb in length. This allele, which encodes coiled-coil domain-containing protein 6, is involved in tumor suppression.]
CCDC6 Gene	NCIT_C18376	[This gene may play a role in tumor suppression.]
BRINP1 wt Allele	NCIT_C54426	[Human BRINP1 wild-type allele is located within 9q32-q33 and is approximately 203 kb in length. This allele, which encodes BMP/retinoic acid-inducible neural-specific protein 1, is involved in the modulation of cellular proliferation, the inhibition of the G1/S transition of the cell cycle, the mediation of non-apoptotic cell death and the regulation of the expression of components of the fibrinolysis pathway. Hypermethylation-based silencing or loss of homozygosity of the gene occurs in many cases of bladder cancer.]
DCC wt Allele	NCIT_C54427	[Human DCC wild-type allele is located in the vicinity of 18q21.3 and is approximately 1190 kb in length. This allele, which encodes netrin receptor DCC protein, plays a role in both axonal guidance and neuronal growth cone formation. Mutation of this gene may be associated with both colorectal and esophageal carcinomas.]
DCC Gene	NCIT_C17358	[This gene plays a role in the regulation of several processes that determine neuronal cell morphology.]
Distress over Physical Problem with Indigestion	NCIT_C107200	[A question about an individual's distress related to their physical problems with indigestion.]
DDX1 wt Allele	NCIT_C54428	[Human DDX1 wild-type allele is located in the vicinity of 18q21.3 and is approximately 40 kb in length. This allele, which encodes ATP-dependent RNA helicase DDX1 protein, is involved in the regulation of processes that are dependent on the alteration of RNA secondary structure.]
DDX1 Gene	NCIT_C24334	[This gene plays a role in the regulation of several processes involving the alteration of RNA secondary structure.]
2p24	NCIT_C25028	[A chromosome band present on 2p]
2: 15682368-15721823	NCIT_C42122	[Physical location of DDX1_Gene]
Distress over Physical Problem with Memory or Concentration	NCIT_C107201	[A question about an individual's distress related to their physical problems with memory or concentration.]