Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Limited in Ability to do Leisure or Recreational Activities Because of Neck or Shoulder	NCIT_C107235	[A question about whether an individual is or was limited in doing leisure or recreational activities because of their neck or shoulder.]
Limited in Ability to do Work Because of Neck or Shoulder	NCIT_C107236	[A question about whether an individual is or was limited in doing work because of their neck or shoulder.]
FGFR1OP wt Allele	NCIT_C54460	[Human FGFR1OP wild-type allele is located within 6q27 and is approximately 41 kb in length. This allele, which encodes FGFR1 oncogene partner protein, plays a role in anchoring microtubules to the centrosome. Translocation of the FGFR10P gene is associated with certain myeloproliferative disorders.]
FGFR1OP Gene	NCIT_C24401	[This gene is involved in the regulation of cell shape, polarity and motility.]
FAK Inhibitor VS-4718	NCIT_C107238	[An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival. The cytoplasmic tyrosine kinase FAK is a signal transducer for integrins and is constitutively activated in various tumor cell types; it is involved in tumor cell invasion, migration and proliferation and plays a key role in the development, function and survival of CSCs.]
SIDT1 wt Allele	NCIT_C54461	[Human SIDT1 wild-type allele is located in the vicinity of 3q13.2 and is approximately 97 kb in length. This allele, which encodes SID1 transmembrane family member 1 protein, may play a role in the regulation of double stranded RNA internalization.]
SIDT1 Gene	NCIT_C20360	[This gene is involved in cellular adhesion and receptor signaling.]
FACT Complex-targeting Curaxin CBL0137	NCIT_C107239	[An orally available curaxin-based agent targeting the Facilitates Chromatin Transcription (FACT) complex, with potential antineoplastic activity. Upon administration, CBL0137 binds to FACT and sequesters the FACT complex on chromatin, which inhibits its activity. This prevents transcription of certain genes involved in cancer-associated signaling pathways; it specifically inhibits the transcription of both NF-kappa B and heat shock transcription factor 1 (HSF1) and simultaneously activates p53. This causes an increase in tumor cell apoptosis and a decrease in tumor cell proliferation, in FACT-positive cancers. In addition, this agent is able to sensitize FACT-positive tumor cells to the cytotoxic effects of other chemotherapeutic agents. FACT, a transcription and replication factor composed of the Structure Specific Recognition Protein (SSRP1) and suppressor of Ty 16 (Spt16) proteins, is expressed in a variety of tumor cells while almost absent in normal cells; its expression is associated with increased tumor aggressiveness and poor prognosis.]
FLRT3 wt Allele	NCIT_C54462	[Human FLRT3 wild-type allele is located in the vicinity of 20p11 and is approximately 12 kb in length. This allele, which encodes leucine-rich repeat transmembrane protein FLRT3 protein, may play a role in cellular adhesion and receptor signaling.]
FLRT3 Gene	NCIT_C24398	[This gene is involved in apoptotic regulation.]
PGAP2 wt Allele	NCIT_C54463	[Human PGAP2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 28 kb in length. This allele, which encodes post-GPI attachment to proteins factor 2 protein, may be involved in the modulation of both stress-induced apoptosis and protein targeting.]
PGAP2 Gene	NCIT_C24404	[This gene may play a role in apoptotic induction and DNA damage checkpoints.]
FRAT1 wt Allele	NCIT_C54464	[Human FRAT1 wild-type allele is located in the vicinity of 10q24.1 and is approximately 3 kb in length. This allele, which encodes proto-oncogene FRAT1 protein, is involved in the promotion of Wnt protein mediated signal transduction.]
FRAT1 Gene	NCIT_C24405	[This gene may play a role in tumor progression and in lymphomagenesis.]
Child-Pugh Class C15	NCIT_C146801	[A total score of 15 for hepatic function, corresponding to class C in the Child-Pugh classification..]
Since First Time Questionnaire Was Answered	NCIT_C146802	[A question about the status of an individual since the time when they first answered a questionnaire.]
Minimally Invasive Interval Debulking Surgery	NCIT_C146803	[Endoscopic or robotic-assisted cytoreductive surgery performed after primary cytoreduction and between courses of chemotherapy.]
Renorrhaphy	NCIT_C146804	[Surgical suturing of a kidney.]
Givosiran	NCIT_C146805	[A proprietary enhanced stabilization chemistry (ESC)-stabilized conjugate composed of the liver-targeted ligand N-acetylgalactosamine (GalNAc) conjugated to small-interfering RNAs (siRNAs) directed against the liver-expressed enzyme aminolevulinic acid synthase 1 (delta-aminolevulinate synthase 1; ALAS1; ALAS-1) that can potentially be used in the treatment of acute hepatic porphyrias (AHPs). Upon subcutaneous administration of givosiran, the GalNAc moiety targets and binds with high affinity to asialoglycoprotein receptors (ASGPRs) expressed on hepatocytes. Once inside the cell, the siRNAs bind to and silence ALAS1 mRNA and inhibit both the translation and expression of the ALAS1 protein. This prevents delta-aminolevulinic acid (ALA) formation, decreases 5-ALA levels and prevents the production of porphyrins and hemes, such as porphobilinogen (PBG). AHPs are a group of metabolic disorders caused by deficiencies of specific enzymes that are responsible for hemoglobulin biosynthesis within the liver, which leads to the accumulation of toxic intermediates, such as ALA and PBG. ALAS1, a liver-expressed, rate-limiting enzyme in the heme biosynthesis pathway, is responsible for the formation of ALA from succinyl-CoA and glycine. ESC enables the subcutaneous dosing of givosiran with increased efficacy, durability and a wide therapeutic index as compared to non-ESC GalNAc-siRNA conjugates.]
Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes	NCIT_C146806	[Allogeneic, off-the-shelf, universal transcription activator-like effector nuclease (TALEN)-engineered T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities. Upon transfusion of allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these cells target and bind to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology, the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby abrogating the potential induction of graft-versus-host disease (GvHD) by the donor T-cells.]