Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Etoposide/Prednisone/Vinblastine	NCIT_C29542	[A combination of agents containing etoposide, prednisone and vinblastine.]
Vortex Mixer	NCIT_C29544	[An electrical rotator that blends or mixes substances or ingredients, in whirling or rotary motion, for homogenizing samples.]
Warburg Therapy	NCIT_C29545	[The cornerstone of oxygenation therapy is the presumption that human disease, including cancer, is caused by a deficit of tissue oxygen. According to proponents, hypoxia results in anaerobic fermentation, a loss of capacity for oxidative detoxification of toxins and metabolic products, and failure of immune killing of invading bacteria and viruses. To restore ability to carry out these functions, oxygenation promoters propose using chemicals they claim will release oxygen in tissue or act as germicides in vivo.]
White Petrolatum/Minerals	NCIT_C29547	[White Petrolatum/Minerals is a compounded agent containing various minerals and white petrolatum, a colloid of semisolid hydrocarbons from petroleum. Approved as a skin protectant, it has topical therapeutic applications since it prevents moisture loss and forms a protective barrier on the skin. White Petrolatum provides an optimal vehicle for delivering many therapeutic ingredients. It is also used in food, plastic and other industries. (NCI04)]
Wild Type and Mutant MGMT Vector	NCIT_C29548	[Wild Type and Mutant MGMT Vectors are genetic carrier vehicles containing an in vivo selection marker derived from natural or mutant O-6 methylguanine-DNA methyltransferase (MGMT) and are used in gene therapy and biomedical research for selection of specific traits in targeted cells, such as genes that confer resistance to chemotherapeutic agents. Mutant MGMTs resistant to the MGMT inactivator O-6-benzylguanine (BG) are potent markers for in vivo selection in irradiated and non-myelo ablated mouse models using BG plus alkylating agents to drive selection. (NCI04)]
Zolimomab Aritox	NCIT_C29549	[An immunotoxin consisting of a murine anti-CD5 monoclonal antibody conjugated to the ricin A chain. The anti-CD5 monoclonal antibody component binds to CD5, a T-cell associated antigen, thereby targeting the delivery of the cytotoxic ricin A chain to T-cells. The ricin A chain component binds to T-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)]
Enalapril Maleate/Hydrochlorothiazide	NCIT_C29539	[A combination preparation of a synthetic angiotensin-converting enzyme (ACE) inhibitor prodrug and a diuretic thiazide, with antihypertensive activity. Enalapril maleate is de-esterified within the cells into its active form enalaprilat that inhibits ACE, thereby prevents the formation of angiotensin II, and blocks angiotensin II mediated activities, including vasoconstriction and stimulation of aldosterone synthesis and secretion, which regulates extracellular sodium concentration. Hydrochlorothiazide inhibits electrolytes reabsorption via binding to Na-Cl cotransporter on the renal distal tubular, thereby increasing excretion of sodium, potassium, chloride, bicarbonate and water. Both agents lead to a reduction in blood pressure.]
Antihypertensive Preparation	NCIT_C29636	[Natural or synthetic Antihypertensive Preparations reduce elevated blood pressure through diverse mechanisms: calcium channel (and conductance) blockage, beta- and alpha-adrenergic blockage, angiotensin-converting enzyme inhibition, etc.. Their effects induce diuresis and peripheral vasodilation. (NCI04)]
Grade 5 Rectal Ulcer, CTCAE	NCIT_C146524
Grade 5 Recurrent Laryngeal Nerve Palsy, CTCAE	NCIT_C146525	[Death]
Grade 5 Renal and Urinary Disorders - Other, Specify, CTCAE	NCIT_C146526	[Death]
Grade 5 Renal Calculi, CTCAE	NCIT_C146527	[Death]
Grade 5 Renal Hemorrhage, CTCAE	NCIT_C146528
Grade 5 Reproductive System and Breast Disorders - Other, Specify, CTCAE	NCIT_C146529	[Death]
Grade 5 Rectal Necrosis, CTCAE	NCIT_C146520
Grade 5 Rectal Obstruction, CTCAE	NCIT_C146521
Grade 5 Rectal Perforation, CTCAE	NCIT_C146522
Grade 5 Rectal Stenosis, CTCAE	NCIT_C146523	[Death]
Zaleplon	NCIT_C29551	[A nonbenzodiazepine from the pyrazolopyrimidine class with hypnotic, sedative, anxiolytic, and muscle relaxant properties. Zaleplon interacts with the gamma-aminobutyric acid (GABA) -A receptor, thereby affecting the chloride channel ionophore complex and potentiating the inhibitory effects of GABA. In addition, zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABA-A/chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding.]
Zinc Undecylenate	NCIT_C29552	[A natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. The zinc provides an astringent action, reducing rawness and irritation. (NCI04)]