Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Histone Fold	NCIT_C13421	[A protein structural element originally identified in the core histones. It is of the helix-loop-helix type and is involved in protein-protein interactions via a "handshake" motif with a histone fold partner. Also involved in protein-DNA interactions.]
DRAP1 Gene	NCIT_C20601	[This gene plays a role in repression of transcription.]
HLA Class II Histocompatibility Antigen DRB	NCIT_C29573	[HLA class II DR beta chain proteins (26-28 kD) form heterodimers with alpha (DRA) chains, both anchored in the membrane. Expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages), alpha/beta heterodimers present peptides derived from extracellular proteins. Hundreds of DRB alleles have been described and typing for these polymorphisms is done for transplantation. (NCI)]
HLA-DR Antigen	NCIT_C16692	[Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants.]
Carbonic Anhydrase Inhibitor	NCIT_C29577	[Any substance that inhibits carbonate dehydratase (carbonic anhydrase), an enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Carbonic anhydrases play important roles in mineral and metabolic homeostasis.]
R-Spondin-3	NCIT_C29579	[R-spondin-3 (272 aa, ~31 kDa) is encoded by the human RSPO3 gene. This protein is involved in the modulation of the canonical Wnt signaling pathway.]
SID1 Transmembrane Family Member 1	NCIT_C29580	[SID1 transmembrane family member 1 (827 aa, ~94 kDa) is encoded by the human SIDT1 gene. This protein may play a role in RNA transport.]
Leucine-Rich Repeat Transmembrane Protein FLRT3	NCIT_C29581	[Leucine-rich repeat transmembrane protein FLRT3 (649 aa, ~73 kDa) is encoded by the human FLRT3 gene. This protein may play a role in cell adhesion.]
FGFR1 Oncogene Partner	NCIT_C29582	[FGFR1 oncogene partner (399 aa, ~43 kDa) is encoded by the human FGFR1OP gene. This protein plays a role in promoting the binding of microtubules to centrosomes.]
Epithelial Mesenchymal Transition Tumor of the Mouse Mammary Gland	NCIT_C29583
Malignant Neoplasms of the Mouse Mammary Gland	NCIT_C21678
TACC2 wt Allele	NCIT_C54540	[Human TACC2 wild-type allele is located within 10q26 and is approximately 265 kb in length. This allele, which encodes transforming acidic coiled-coil-containing protein 2, is putatively involved in the organization of centrosomal microtubules during the cell cycle. Decreased expression of the TACC2 gene is associated with the progression of breast tumors.]
TACC2 Gene	NCIT_C20801	[This gene plays a putative role in the regulation of cell growth and differentiation.]
Post-GPI Attachment to Proteins Factor 2	NCIT_C29584	[Post-GPI attachment to proteins factor 2 (254 aa, ~29 kDa) is encoded by the human PGAP2 gene. This protein is involved in the posttranslational modification of proteins with glycophosphoinositol anchors.]
TACC3 wt Allele	NCIT_C54541	[Human TACC3 wild-type allele is located in the vicinity of 4p16.3 and is approximately 24 kb in length. This allele, which encodes transforming acidic coiled-coil-containing protein 3, plays a role in the regulation of microtubule polymerization during mitosis. The TACC3 gene is associated with several types of cancer including multiple myeloma, breast tumors and ovarian carcinomas.]
TACC3 Gene	NCIT_C24841	[This gene plays a role in the regulation of mitosis.]
Proto-Oncogene FRAT1 Protein	NCIT_C29585	[Proto-oncogene FRAT1 (279 aa, ~29 kDa) is encoded by the human FRAT1 gene. This protein plays a role in the positive regulation of the Wnt signaling pathway.]
Tyrosine-Protein Kinase FRK	NCIT_C29586	[Tyrosine-protein kinase FRK (505 aa, ~58 kDa) is encoded by the human FRK gene. This protein plays a role in tyrosine phosphorylation and the negative regulation of cell proliferation.]
Fibroblast Growth Factor Receptor Substrate 2	NCIT_C29587	[Fibroblast growth factor receptor substrate 2 (508 aa, ~57 kDa) is encoded by the human FRS2 gene. This protein plays a role in the propagation of signals from fibroblast growth factor receptors and nerve growth factor receptors to their downstream signaling proteins.]
Fibroblast Growth Factor Receptor Substrate 3	NCIT_C29588	[Fibroblast growth factor receptor substrate 3 (492 aa, ~54 kDa) is encoded by the human FRS3 gene. This protein plays a role in linking fibroblast growth factor receptors and nerve growth factor receptors to downstream signaling factors.]