Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| PTB Domain | NCIT_C26118 | [Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn.] |
| FRS3 Gene | NCIT_C24820 | [This gene is involved in signal transduction.] |
| Phenylalanyl-tRNA Ligase Beta Subunit | NCIT_C29589 | [Phenylalanine-tRNA ligase beta subunit (589 aa, ~66 kDa) is encoded by the human FARSB gene. This protein plays a role in attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA.] |
| NCBI_Taxon_ID | NCIT_C54539 | [The NCBI_Taxon_ID property is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon.] |
| Immunofixation | NCIT_C54536 | [An enhancement of immunoelectrophoresis in which a series of post-electrophoretic gel slabs are layered with cellulose-acetate gels saturated with specific antibodies. The resulting antigen-antibody complexes fixed on the second gel may then be stained, allowing sensitive and specific qualitative visual identification of paraproteins by electrophoretic position. It can be used to identify specific proteins in the blood or urine. It has greatest application in the identification and monitoring of monoclonal proteins that are produced in conditions like Waldenstom's macroglobulinaemia and multiple myeloma.] |
| Immunoelectrophoresis | NCIT_C51958 | [A laboratory testing method to determine the concentrations of immunoglobulins in the blood.] |
| MGI_Accession_ID | NCIT_C54537 | [The identifier used by Jackson Laboratories Mouse Genome Informatics group to label inbred mouse strains maintained by Jackson Laboratory and other things such as mouse genes and alleles.] |
| Concept_In_Subset | NCIT_C54538 | [Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.] |
| Tumor Suppressor Candidate 2 | NCIT_C29590 | [Tumor suppressor candidate 2 (110 aa, ~12 kDa) is encoded by the human TUSC2 gene. This protein is involved in cell cycle regulation and tumor suppression.] |
| 3-Ketodihydrosphingosine Reductase | NCIT_C29591 | [3-ketodihydrosphingosine reductase (332 aa, ~36 kDa) is encoded by the human KDSR gene. This protein is involved in sphingolipid metabolism.] |
| KDSR Gene | NCIT_C24410 | [This gene plays a role in glycosphingolipid metabolism.] |
| Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 1 | NCIT_C29592 | [Epidermal growth factor receptor kinase substrate 8-like protein 1 (723 aa, ~80 kDa) is encoded by the human EPS8L1 gene. This protein is involved in the stimulation of son of sevenless homolog 1-dependent guanine exchange activity.] |
| SH3 Domain | NCIT_C13340 | [A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH3 domain is a protein-binding domain that interacts with cytoskeletal proteins.] |
| Actin-Binding Protein | NCIT_C16257 | [A diverse group of proteins that bind to actin. These proteins direct a complex network of protein filaments that provide stability to the cellular infrastructure by supporting the dynamic motility of microfilaments, thereby enabling intracellular translocation and organelle transport.] |
| Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 2 | NCIT_C29593 | [Epidermal growth factor receptor kinase substrate 8-like protein 2 (715 aa, ~81 kDa) is encoded by the human EPS8L2 gene. This protein plays a role in the positive regulation of son of sevenless homolog 1-dependent guanine exchange activity.] |
| Growth Arrest-Specific Protein 2 | NCIT_C29594 | [Growth arrest-specific protein 2 (313 aa, ~35 kDa) is encoded by the human GAS2 gene. This protein may be involved in both apoptosis and cytoskeletal rearrangement.] |
| Essential Amino Acid | NCIT_C29595 | [Refer to those amino acids that can not be synthesized in the body and can only be obtained through food supply.] |
| Dietary Amino Acid | NCIT_C68442 | |
| Amino Acid | NCIT_C231 | [Any organic compounds containing amino (-NH2) and carboxyl (-COOH) groups. In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins.] |
| Non-Essential Amino Acid | NCIT_C29596 | [Refers to those amino acids that your body can create out of other chemicals found in your body.] |