Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Lung	NCIT_C12468	[One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border.]
PHLDA2 Gene	NCIT_C20898	[This gene is putatively involved in the regulation of placental growth.]
Colorectal Cancer pMX TNM Finding v6	NCIT_C60854	[Colorectal cancer in which distant metastases cannot be assessed. (from AJCC 6th Ed.)]
Colorectal Cancer Pathologic Distant Metastasis TNM Finding v6	NCIT_C60838	[A pathologic finding about one or more characteristics of colorectal cancer, following the rules of the TNM AJCC v6 classification system as they pertain to distant metastases.]
Proto-Oncogene Wnt-3	NCIT_C21247	[Proto-oncogene Wnt-3 (355 aa, ~40 kDa) is encoded by the human WNT3 gene. This protein plays a role in binding to receptors of the frizzled family to stimulate signaling during neural tube morphogenesis.]
Colorectal Cancer pM0 TNM Finding	NCIT_C60855	[Colorectal cancer with no evidence of distant metastasis. (from AJCC 6th Ed.)]
HPR Gene	NCIT_C21248	[This gene plays a role in the innate immunity of humans to a non-pathogenic species of African trypanosomes.]
Peptidase Gene	NCIT_C26003	[A gene that encodes an enzyme that is capable of hydrolyzing the peptide bonds found between amino acids in proteins.]
Hydrolysis	NCIT_C16702	[A chemical reaction in which a water molecule is added to a compound. This addition often involves the splitting or cleavage of the molecule. The hydroxyl group is incorporated into one fragment of the compound and the hydrogen atom in the other.]
Colorectal Cancer pM1 TNM Finding v6 and v7	NCIT_C60856	[Colorectal cancer with distant metastasis. (from AJCC 6th and 7th Eds.)]
Colorectal Cancer Pathologic Distant Metastasis TNM Finding v7	NCIT_C89956	[A pathologic finding about one or more characteristics of colorectal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for colorectal cancer. (from AJCC 7th Ed.)]
CENPF Gene	NCIT_C21252	[This gene is involved in mitotic regulation.]
ATP-Binding Cassette Sub-Family G Member 2	NCIT_C21253	[ATP-binding cassette sub-family G member 2 (655 aa, ~72 kDa) is encoded by the human ABCG2 gene. This protein is involved in the transport of urate, heme, porphyrin and xenobiotics.]
ABC Transporter	NCIT_C17750	[A family of transmembrane proteins that usually function as dimers to hydrolyze ATP, which permits them to transport a wide variety of substrates across cellular membranes. These proteins consist of two distinct domains, a transmembrane domain and a nucleotide-binding domain. ATP binding is required for both dimerization and transporter activity.]
Translocase	NCIT_C158419	[A class of enzymes that catalyze the movement of ions or molecules across or within membranes.]
E3 Ubiquitin-Protein Transferase	NCIT_C21254	[An ATP-dependent aminoacyltransferase that catalyzes the third step in the ubiquitination reaction via the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to lysine residues found in the final substrate protein.]
Acyltransferase	NCIT_C16259	[Class of enzymes that catalyze the transfer of acyl groups, most commonly a carboxylic acyl group forming either esters or amides.]
Ubiquitin Protein Ligase	NCIT_C26065	[Ubiquitin protein ligase enzymes catalyze the formation of a covalent peptide bond between the carboxy-terminal glycine of ubiquitin proteins and lysine alpha-amino group of other proteins. This typically marks proteins for either nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme, a conjugating enzyme, and a ligase.]
Ubiquitin-Transferase Gene	NCIT_C133710	[Genes encoding enzymes that catalyze the third step in the ubiquitination reaction via the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to the final protein substrate.]
Ubiquitination Regulation Protein	NCIT_C95242	[A protein that plays a role in the regulation of ubiquitination of other proteins and, subsequently, modulates the targeting of proteins for degradation by the proteasome.]