Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Ubiquitination	NCIT_C19358	[Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.]
TRIM Family	NCIT_C21255	[Genes belonging to this family are implicated in several inherited human diseases (Familial Mediterranean Fever, X-linked Opitz/GBBB syndrome, and Mulibrey nanism) and in tumorigenesis. The TRIM proteins have a strong self-association ability that is mediated by their coiled-coil region. This property results in the formation of large protein complexes that identify diverse discrete sub-cellular structures. The formation of these cellular compartments is strictly dependent on the integrity of the Tripartite Motif. The TRIM proteins might play a role in cell sub-compartmentalization.]
TRIM Motif	NCIT_C13974	[The TRIM motif includes three cysteine-rich zinc-binding domains, a RING finger, a B-box, and a coiled-coil region. The order of the sub-domains is conserved, with the RING finger, B-box and coiled -coil domains arranged from the N to C-terminus. However, the number of B-boxes can vary. (NCI)]
RTN4 Gene	NCIT_C21250	[This gene plays a role in cell organization/biogenesis.]
Cell Growth Regulation	NCIT_C18080	[Cell growth regulation controls the rate, or the mechanism, of complex coordinated cellular phenomena that promote cell metabolism, cell growth, and cell division.]
E3 Ubiquitin/ISG15 Ligase TRIM25	NCIT_C21251	[E3 ubiquitin/ISG15 ligase TRIM25 (630 aa, ~71 kDa) is encoded by the human TRIM25 gene. This protein is involved in both innate immunity and protein ubiquitination.]
K ATP Channel-Associated Diabetes Mellitus	NCIT_C131847	[Diabetes mellitus caused by activating mutation(s) in genes (KNCJ11 and/or ABCC8) encoding either of the 2 proteins (Kir6.2 and/or SUR1) that make up the pancreatic beta cell adenosine triphosphate-sensitive potassium channel, which is crucial for the regulation of glucose-induced insulin secretion.]
K ATP Permanent Neonatal Diabetes	NCIT_C131848	[K ATP channel-associated neonatal diabetes mellitus that does not resolve spontaneously.]
Hexose-6-phosphate Dehydrogenase Deficiency	NCIT_C131849	[Decreased activity of hexose-6-phosphatase due to autosomal recessive mutation(s) in the H6PD gene. This enzyme is necessary to generate NADPH, a cofactor in the 11-beta-hydroxysteroid dehydrogenase pathway required for conversion of cortisone to cortisol. The condition is characterized by hyperandrogenism as a result of increased adrenocorticotropic hormone stimulation of the adrenal gland due to failure of cortisol-mediated down-regulation, and is clinically indistinguishable from 11-beta HSD type 1 deficiency.]
Herringbone Growth Pattern	NCIT_C35887
SGRQ-C - Short of Breath When Bend Over	NCIT_C106870	[St. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) Some more questions about your cough and breathlessness: I am short of breath when I bend over.]
Storiform Growth Pattern	NCIT_C35888
SGRQ-C - Coughing Disturbs My Sleep	NCIT_C106871	[St. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) Some more questions about your cough and breathlessness: My coughing or breathing disturbs my sleep.]
Whorling Growth Pattern	NCIT_C35889
Hypothyroxinemia	NCIT_C131820	[Decreased concentration of thyroxine.]
Iodine I 131 MIP-1095	NCIT_C131821	[A radioconjugate composed of MIP-1095, a urea-based ligand for the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) radiolabeled with iodine I 131 (I131), with potential antineoplastic activity. Upon administration of iodine I 131 MIP-1095, the MIP-1095 moiety selectively targets and binds to the extracellular domain of PSMA, thereby delivering cytotoxic iodine I 131 specifically to PSMA-expressing cancer cells. PSMA is a transmembrane glycoprotein that is highly expressed by malignant prostate epithelial cells and certain other tumor cells.]
Antineoplastic Radiopharmaceutical Agent	NCIT_C129819	[Any radiopharmaceutical agent that targets cancer cells and exerts an antineoplastic effect through radiotoxicity.]
Malva sylvestris/Alcea digitata Herbal Compound	NCIT_C131822	[A traditional Persian medicine composed of Malva sylvestris (M. sylvestris) and Alcea digitata (A. digitata; Boiss), with potential use for the treatment of radiation- and chemotherapy-induced xerostomia, and potential immunomodulating, anti-oxidant and antimicrobial activities. Upon administration to the mouth, M. sylvestris/A. digitata herbal compound may lubricate the mouth and throat, and may improve the symptoms of dry mouth, thereby preventing tooth decay and improving chewing, eating, tasting, swallowing, and speaking. M. sylvestris/A. digitata herbal compound may also improve mucositis by modulating the immune system, thereby preventing infection, reducing inflammation and promoting wound healing.]
Sodium Nitrate Supplement	NCIT_C131823	[A dietary supplement containing sodium nitrate, that can be used for nitrate supplementation purposes. Upon oral administration, nitrate is absorbed by the body and is partially converted to nitrite, which is stored and circulated in the blood, leading to an increase in nitrite levels. Nitrate, and to some extent nitrite, accumulates in saliva and may enhance salivary flow, which may help to treat dry mouth and chemo- and radiation-induced oropharyngeal problems.]
Dietary Supplement	NCIT_C1505	[Oral preparations containing dietary ingredient(s) intended to supplement the diet. Dietary ingredients include vitamins, minerals, herbs, amino acids, extracts and metabolites.]