Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Modified Vitamin D Binding Protein Macrophage Activator EF-022	NCIT_C131824	[A modified version of vitamin D binding protein (VDBP; Gc protein) macrophage activator, with potential antineoplastic and anti-angiogenic activities. Upon administration, modified VDBP-macrophage activator EF-022, acting in a similar manner as VDBP-macrophage activating factor (GcMAF), is able to activate tumoricidal macrophages, thereby enhancing the killing and eradication of cancer cells. In addition, EF-022 may inhibit tumor cell proliferation, migration and angiogenesis. VDBP is a glycoprotein and precursor for macrophage activating factor (MAF), which promotes macrophage activation; however VDBP can be deglycosylated by serum alpha-N-acetylgalactosaminidase, which is secreted from cancerous cells, and cannot be converted to MAF. Thus, the macrophage activation cascade is often impaired in tumor cells and plays a key role in tumor immunosuppression. Modification of VDBP stabilizes MAF.]
Storage	NCIT_C60824	[The act of safekeeping goods in a depository.]
Instruction Imperative	NCIT_C64913
Lipase Hypersecretion Syndrome	NCIT_C60825	[A rare disorder resulting from neoplastic exocrine excess. It is typically seen in 10-15 % of patients with pancreatic acinar cell carcinoma. Clinical signs include subcutaneous fat necrosis, polyarthralgia and osteolytic lesions. Clinical course may proceed to non-bacterial thrombotic endocarditis. Clinical prognosis is poor due to its usual onset with advanced disease.]
Cellular Pseudostratification	NCIT_C60826
Precaution	NCIT_C60827	[A measure taken beforehand to prevent harm or secure good.]
14-3-3 Family	NCIT_C21256	[The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)]
RXY/FXpSXP Motif	NCIT_C13976	[The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RXY/FXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)]
RSXpSXP Motif	NCIT_C13975	[The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RSXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)]
Run By	NCIT_C60820	[Indicates the person or authoritative body who performed a test.]
Breast Cancer Suppressor-2	NCIT_C21257	[Inactivation of tumor suppressor BCDS2 Protein, encoded by Breast Cancer, Ductal 2 Gene, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast. (OMIM, LocusLink, and NCI)]
Solubility	NCIT_C60821	[The ability of a particular substance to dissolve in a particular solvent (yielding a saturated solution).]
Physicochemical Property Analysis	NCIT_C134259	[The tests performed to assess/determine physical and chemical characteristics of the drug substance.]
RTN1 Gene	NCIT_C21258	[This gene plays a protein trafficking and is involved in exocytosis.]
Trafficking Protein Gene	NCIT_C26006	[Trafficking Protein Genes encode proteins involved in various cellular sorting and transport mechanisms - such as gated transport, protein translocation, and vesicular transport - whereby cellular proteins are positioned, sorted, and directed to, sequestered in, or moved from one cellular compartment to another specific correct subcellular cellular compartment for proper function. (NCI)]
Exocytosis	NCIT_C16568	[Cellular release of secretory products from within membrane-limited vesicles or granules.]
Neuroendocrine-Specific Protein	NCIT_C21259	[Three different proteins encoded by the RTN1 gene. They are identical at their 3-prime ends but have unique amino termini. The common carboxyl-terminal region contains 2 large hydrophobic domains. The proteins are localized to membranes of the endoplasmic reticulum, leading to their proposed designation as 'reticulons.' Their function is largely unknown. (from OMIM)]
Diluent	NCIT_C60823	[Any liquid or solid material used to lessen the strength or flavor of a solution or mixture of another ingredient.]
Reagent	NCIT_C802	[Any natural or synthetic substance used in a chemical or biological reaction in order to produce, identify, or measure another substance.]
ITGB2 Gene	NCIT_C21263	[This gene is involved in the mediation of cellular adhesion and cell-surface signal transduction.]