Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Leukocyte Adhesion Deficiency	NCIT_C27874	[A rare autosomal recessive immunodeficiency disorder caused by deficiency of CD18 expression. It is characterized by defects in neutrophil adhesion and bacterial infections.]
ABCB6 Gene	NCIT_C21264	[This gene is involved in multi-drug resistance, antigen presentation and is postulated to play a role in mitochondrial function.]
Hepatocellular Carcinoma	NCIT_C3099	[A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.]
Drug Efflux	NCIT_C19411	[Transport of drugs out of a cell. A mechanism of drug resistance.]
Multidrug Resistance Process	NCIT_C17745	[Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.]
ABI2 Gene	NCIT_C21265	[This gene is involved in the regulation of signal transduction events.]
Adaptor Signaling Protein Gene	NCIT_C25997	[A class of genes that encode signaling pathway proteins that function to mediate the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions. (from Oncogene 2001;20:6315-21)]
Tyrosine Phosphorylation	NCIT_C18497	[Tyrosine phosphorylation involves the introduction of a phosphoryl group into a compound through the formation of an ester bond between a tyrosine residue in the compound and a phosphorus moiety.]
TNK2 Gene	NCIT_C21266	[This gene is involved in the negative regulation of cell growth.]
Non-Receptor Tyrosine Kinase Gene	NCIT_C25971	[Originally identified in the Rous sarcoma virus src transforming gene, Non-Receptor Tyrosine Kinase Genes encode Protein Tyrosine Kinases, enzymes important in control of cell growth, proliferation, differentiation, and transformation that do not function as receptors, but catalyze tyrosine phosphorylation of proteins with ATP, or other nucleotides as phosphate donors.]
Safety	NCIT_C60828	[The state of being certain that adverse effects will not be caused by some agent under defined conditions.]
Squamoid Corpuscle	NCIT_C60829
Death Domain-Associated Protein 6	NCIT_C21260	[Death domain-associated protein 6 (740 aa, ~81 kDa) is encoded by the human DAXX gene. This protein is involved in the negative regulation of both gene transcription and protein ubiquitination.]
Transcription Regulatory Protein	NCIT_C26199	[A protein that is involved in the regulation of transcription.]
MCAM Gene	NCIT_C21261	[This gene plays a role in cell adhesion and receptor signaling.]
Breast Cancer, 11;22 Translocation Associated Protein	NCIT_C21262	[The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048)]
Retired Concept 2017	NCIT_C143136
Focal Lipodystrophy	NCIT_C131814	[Loss of subcutaneous fat confined to small area(s) of the body.]
Lipodystrophy	NCIT_C97093	[A congenital or acquired disorder characterized by abnormal loss or redistribution of the adipose tissue in the body.]
Generalized Lipodystrophy	NCIT_C131815	[Almost complete absence of subcutaneous and/or visceral adipose tissue.]