Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Middle Jugular Lymph Node Group (Level III)	NCIT_C132511	[Lymph nodes located around the middle third of the internal jugular vein, extending from the inferior border of the hyoid bone (above) to the inferior border of the cricoid cartilage (below). The anterior (medial) boundary is the lateral border of the sternohyoid muscle, and the posterior (lateral) boundary is the posterior border of the sternocleidomastoid muscle. These nodes are at greatest risk for harboring metastases from cancers arising from the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. (AJCC 8th ed.)]
Lower Jugular Lymph Node Group (Level IV)	NCIT_C132512	[Lymph nodes located around the lower third of the internal jugular vein, extending from the inferior border of the cricoid cartilage (above) to the clavicle below. The anterior (medial) boundary is the lateral border of the sternohyoid muscle and the posterior (lateral) boundary is the posterior border of the sternocleidomastoid muscle. These nodes are at greatest risk for harboring metastases from cancers arising from the hypopharynx, thyroid, cervical esophagus, and larynx. (AJCC 8th ed.)]
Posterior Triangle Lymph Node Group (Sublevels VA and VB)	NCIT_C132513	[This group is composed predominantly of the lymph nodes located along the lower half of the spinal accessory nerve and the transverse cervical artery. The supraclavicular nodes also are included in the posterior triangle group. The superior boundary is the apex formed by the convergence of the sternocleidomastoid and trapezius muscles; the inferior boundary is the clavicle; the anterior (medial) boundary is the posterior border of the sternocleidomastoid muscle; and the posterior (lateral) boundary is the anterior border of the trapezius muscle. Thus, sublevel VA includes the spinal accessory nodes, whereas sublevel VB includes the nodes following the transverse cervical vessels and the supraclavicular nodes, with the exception of the Virchow node, which is located in level IV. The posterior triangle nodes are at greatest risk for harboring metastases from cancers arising from the nasopharynx, oropharynx, and cutaneous structures of the posterior scalp and neck. (AJCC 8th ed.)]
Anterior Compartment Lymph Node Group (Level VI)	NCIT_C132514	[Lymph nodes in this compartment include the pretracheal and paratracheal nodes, precricoid (Delphian) node, and the perithyroidal nodes, including the lymph nodes along the recurrent laryngeal nerves. The superior boundary is the hyoid bone; the inferior boundary is the suprasternal notch; and the lateral boundaries are the common carotid arteries. These nodes are at greatest risk for harboring metastases from cancers arising from the thyroid gland, glottic and subglottic larynx, apex of the piriform sinus, and cervical esophagus. (AJCC 8th ed.)]
Superior Mediastinal Lymph Node Group (Level VII)	NCIT_C132515	[Lymph nodes in this group include pretracheal, paratracheal, and esophageal groove lymph nodes, extending from the level of the suprasternal notch cephalad and up to the innominate artery caudad. These nodes are at greatest risk of involvement by thyroid cancer and cancer of the esophagus. (AJCC 8th ed.)]
CDISC Clinical Classification NSAA Test Name Terminology	NCIT_C132516	[Test names of clinical classification questions associated with the North Star Ambulatory Assessment (NSAA) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).]
CDISC Clinical Classification NSAA Test Code Terminology	NCIT_C132517	[Test codes of clinical classification questions associated with the North Star Ambulatory Assessment (NSAA) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).]
XRCC6 Gene	NCIT_C20568	[This gene is involved in DNA repair and DNA metabolic processes.]
Ku Subunit Gene	NCIT_C20566	[Ku Subunit Genes encode tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI)]
Shunt	NCIT_C20569
TERF1 Gene	NCIT_C20563	[This gene plays a role in telomere length maintenance and the inhibition of telomerase activity.]
TINF2 Gene	NCIT_C20564	[This gene plays a role in the regulation of telomere length.]
Mixed Embryonal Carcinoma and Teratoma	NCIT_C3756	[A germ cell tumor characterized by the presence of an embryonal carcinoma component and a teratoma component.]
LIG4 Gene	NCIT_C20565	[This gene plays a critical role in the regulation of nonhomologous DNA end joining and in V(D)J recombination.]
Telomere Capping	NCIT_C20339	[Processes that prevent chomosome ends from degradation and from being recognized as a double strand break.]
HMG Family Gene	NCIT_C20570	[Human HMG Family Genes encode ubiquitous non-histone HMG chromatin proteins originally named according to PAGE electrophoretic mobility, shared physical properties, and association with chromatin. Canonical HMG proteins are subdivided into 3 superfamilies with characteristic functional sequence motifs: HMGB (formerly HMG-1/-2), HMGN (formerly HMG-14/-17), and HMGA (formerly HMG-I/Y/C). DNA-binding HMG proteins appear to have roles in matrix stabilization, ssDNA protection, replication, and transcription that influence cell growth, proliferation, differentiation, and death. (NCI)]
Canonical HMG Gene	NCIT_C20571
HMG Motif Genes	NCIT_C20572
HMGA Family Gene	NCIT_C20573	[Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)]
FGFR2 NM_000141.4:c.758C>G	NCIT_C107590	[A nucleotide substitution at position 758 of the coding sequence of the FGFR2 gene where cytosine has been mutated to guanine.]