Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Neuropathogenesis	NCIT_C20630	[The origin or causation of a disease of the nervous system.]
Pathogenesis	NCIT_C18264	[The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process.]
Comparative Pathology	NCIT_C20631	[Biological field of study concerned with the analysis of similarities and differences in specific characteristics between different diseases.]
Comparative Biology	NCIT_C19301	[Biological field of study concerned with the analysis of similarities and differences in specific traits between different species.]
Pathophysiology	NCIT_C20632	[Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com)]
Unknown Primary Tumor pN3b TNM Finding v8	NCIT_C132675	[Unknown primary tumor with metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node. (from AJCC 8th Ed.)]
Unknown Primary Tumor pN3 TNM Finding v8	NCIT_C132673	[Unknown primary tumor with metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node. (from AJCC 8th Ed.)]
Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage	NCIT_C132676	[A term that refers to the staging of unknown primary tumor (except for EBV-related and HPV-related tumors) and metastatic cervical adenopathy according to the American Joint Committee on Cancer, 8th edition.]
Metastatic Malignant Neoplasm of Unknown Primary	NCIT_C8566	[The spread of a malignant neoplasm from an unknown primary to another region remote from the primary site.]
Stage III Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8	NCIT_C132677	[Stage III includes: T0, N1, M0. T0: No evidence of primary tumor. N1: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE (extranodal extension)(-). M0: No distant metastasis. (AJCC 8th Ed.)]
Stage IVA Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8	NCIT_C132678	[Stage IVA includes: T0, N2, M0. T0: No evidence of primary tumor. N2: Metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). M0: No distant metastasis. (AJCC 8th Ed.)]
GTF2B Gene	NCIT_C20648	[This gene is involved in transcriptional initiation and regulation.]
Stage IVB Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8	NCIT_C132679	[Stage IVB includes: T0, N3, M0. T0: No evidence of primary tumor. N3: Metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node. M0: No distant metastasis. (AJCC 8th Ed.)]
GTF2E1 Gene	NCIT_C20649	[This gene is involved in transcriptional activation.]
TFIIE Subunit Gene	NCIT_C20647	[TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level transcription. Both subunits are essential to form a stable preinitiation complex. High levels of gene transcription by RNA polymerase II depend on high rates of transcription initiation and reinitiation. Initiation requires recruitment of the complete transcription machinery to a promoter, a process facilitated by activators and chromatin remodeling factors. Reinitiation occurs through a different pathway. After initiation, a subset of the transcription machinery remains at the promoter, forming a platform for assembly of a second transcription complex as a scaffold for formation of a functional reinitiation complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and Mediator may promote high levels of transcription. (from OMIM 189962).]
High Resolution Computed Tomography	NCIT_C20644	[Defined as thin section (1-2 mm collimation) CT optimized by using a high-spatial-frequency (bone) algorithm. (from Radiol Clin North Am 1991;29:1043-9)]
Computed Tomography	NCIT_C17204	[A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.]
Spiral CT	NCIT_C20645	[A method of computed tomography (CT) that uses continuous rotation of the X-ray tube and continuous transport of the patient through the scanning aperture that allows the rapid acquisition of a volume of CT data. Advantages over conventional CT include: rapid acquisition of a large volume of data within a single breath-hold, thus minimizing respiration artifact and misregistration between slices; the ability to reconstruct images retrospectively at any level within the scanned volume; optimization of intravenous contrast enhancement due to the short scan times; improved multi-planar and 3-D reconstruction; and the potential for radiation dose reduction. Same as helical computed tomography. (British Journal of Radiology 1994 May;67(797):436-44)]
Topoisomerase	NCIT_C20646	[Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin.]
Unknown Primary Tumor pN2a TNM Finding v8	NCIT_C132670	[Unknown primary tumor with metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]