Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Unknown Primary Tumor pN2 TNM Finding v8 | NCIT_C132669 | [Unknown primary tumor with metastasis in a single ipsilateral or contralateral cervical lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral cervical lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). ENE detected on histopathologic examination is designated as ENEmi (microscopic ENE equal or less than 2 mm) or ENEma (major ENE more than 2 mm). (from AJCC 8th Ed.)] |
| Ommaya Reservoir | NCIT_C20640 | [A plastic, dome-shaped device, with a catheter attached to the underside used to deliver chemotherapy to the central nervous system.] |
| Unknown Primary Tumor pN2b TNM Finding v8 | NCIT_C132671 | [Unknown primary tumor with metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)] |
| Performance Status | NCIT_C20641 | [A measure of how well a patient is able to perform ordinary tasks and carry out daily activities.] |
| Unknown Primary Tumor pN2c TNM Finding v8 | NCIT_C132672 | [Unknown primary tumor with metastases in bilateral or contralateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)] |
| Stereotaxis | NCIT_C20642 | [Use of a computer and scanning devices to create three-dimensional pictures.] |
| Three Dimensional Imaging | NCIT_C18485 | [Technique to produce 3D images to provide the ability to visualize important structures in great detail. Traditionally CT and MRI scans produced static output on film. To produce 3D images, many scans are made, and then combined by computers to produce a 3D model, which can then be manipulated by the physician. 3D ultrasounds are produced using a somewhat similar technique.] |
| Unknown Primary Tumor Pathologic Cervical Lymph Nodes TNM Finding v8 | NCIT_C132665 | [A pathologic finding about one or more characteristics of an unknown primary tumor, following the rules of the TNM AJCC v8 classification system as they pertain to staging of cervical lymph nodes. It applies to patients who are treated surgically with a cervical lymph node dissection. (from AJCC 8th Ed.)] |
| Schiller Test | NCIT_C20643 | [A preliminary test for cancer of the uterine cervix in which the cervix is painted with an aqueous solution of iodine and potassium iodide and which shows up healthy tissue by staining it brown and possibly cancerous tissue as white or yellow due to its failure to take up the stain because of a deficiency of glycogen in the cells. It was introduced by Walter Schiller, an american pathologist, in 1933. (from fasthealth.com)] |
| Unknown Primary Tumor pN3a TNM Finding v8 | NCIT_C132674 | [Unknown primary tumor with metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)] |
| Demethylating Agent | NCIT_C132686 | [Any agent that inhibits or prevents DNA methylation or agents that promote the removal of methyl groups from DNA.] |
| Florbetaben (18F) | NCIT_C132687 | [A stilbene derivative labeled with the positron-emitting isotope fluorine F 18, that may be used for positron emission tomography (PET) detection of beta-amyloid neuritic plaques and other amyloid protein deposits. Upon administration, F 18-florbetaben exhibits differential retention in regions that contain certain amyloid deposits. Differences in signal intensity between tissues showing specific and non-specific uptake of F 18-florbetaben allows for the detection of amyloid neuritic plaques in patients being evaluated for Alzheimer's disease, and potentially the detection of amyloid deposits in amyloidosis.] |
| Head and Neck Cancer TNM Finding v8 | NCIT_C132632 | [A finding about one or more characteristics of head and neck cancer, following the rules of the TNM AJCC v8 classification system.] |
| Lip and Oral Cavity Cancer Clinical TNM Finding v8 | NCIT_C132689 | [A clinical finding about one or more characteristics of lip and oral cavity cancer, following the rules of the TNM AJCC v8 classification system. The assessment of the primary tumor is based on inspection and palpation of the oral cavity and neck. Additional studies may include CT, MRI, or ultrasound. (from AJCC 8th Ed.)] |
| Head and Neck Cancer Clinical TNM Finding v8 | NCIT_C132633 | [A clinical finding about one or more characteristics of head and neck cancer, following the rules of the TNM AJCC v8 classification system.] |
| MED6 Gene | NCIT_C20659 | [This gene is involved in transcriptional regulation and can function as either a repressor or an activator.] |
| Mediator Complex Component Gene | NCIT_C20658 | [Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Mediator Complex Component Genes encode the mediator complex, one type of intermediary and which consists of approximately 20 polypeptides. It is physically associated with RNA polymerase II and is essential for transcriptional activation. (from OMIM 602984)] |
| TFIIH Core Subunit Gene | NCIT_C20655 | [Human TFIIH Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, ERCC2, and ERCC3, encode six subunits of the nuclear core-TFIIH basal transcription factor. These subunits are involved in transcription-coupled DNA nucleotide excision repair, and basal RNA polymerase II transcription when complexed to CAK (CDK7/Cyclin H/MAT1). Phosphorylated 548-aa 62-kDa GTF2H1 contains 2 BSD domains. The 395-aa 44-kDa GTF2H2 contains a C4-type zinc finger and a VWFA domain. The N-terminus interacts with and regulates XPD, while the C-terminus promotes escape of RNAPII from the promoter. GTF2H2 also interacts with XPB, p62, and p34. Containing a C4-type zinc finger, 303-aa 34-kDa GTF2H3 anchors XPB. ATP-dependent 760-aa 87-kDa ERCC2 DNA helicase anchors CAK to core-TFIIH; interaction with p44 stimulates helicase activity. ERCC3 is a 782-aa 89-kDa ATP-dependent DNA helicase. (NCI)] |
| TFIIH Subunit Gene | NCIT_C20654 | [For transcription initiation, the nonphosphorylated RNA polymerase II is recruited by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ to form a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation and TFIIH contains a kinase activity for phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD. A 52-kD subunit has also been identified as a component of the TFIIH core, along with p89, p62, p44, and p34. (from OMIM, LocusLink and NCI)] |
| GTF2H1 Gene | NCIT_C20656 | [This gene is involved in cell cycle regulation, transcriptional initiation and DNA repair.] |