Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
ERCC2 Gene	NCIT_C20657	[Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)]
Stage IVC Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8	NCIT_C132680	[Stage IVC includes: T0, Any N, M1. T0: No evidence of primary tumor. M1: Distant metastasis. (AJCC 8th Ed.)]
Anti-CD40/Anti-TAA Bispecific Monoclonal Antibody ABBV-428	NCIT_C132681	[A bispecific monoclonal antibody composed of a binding domain for an epitope found on the cell-surface receptor CD40 linked to a binding domain directed to an as of yet undisclosed tumor-associated antigen (TAA), with potential immunomodulating and antineoplastic activities. Upon administration of anti-CD40/anti-TAA bispecific monoclonal antibody ABBV-428, the anti-TAA moiety targets and binds to the TAA expressed on the tumor cells. The agonistic anti-CD40 moiety targets and binds to various CD40-expressing immune cells. This leads to the activation and proliferation of effector and memory T-cells, and enhances the immune response against tumor cells, which kills and inhibits the proliferation of the TAA-expressing tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as macrophages, B-lymphocytes, and dendritic cells (DCs); it plays a key role in the activation of the immune system.]
TFIIF Subunit Gene	NCIT_C20651	[Human TFIIF Subunit Genes, GTF2F1 Gene and GTF2F2 Gene, encode similar alpha (517-aa, 58-kDa, phosphorylated) and beta (249-aa, 28-kDa) subunits of heterodimeric nuclear general transcription initiation factor TFIIF, which binds to and recruits RNA polymerase II to the initiation complex in collaboration with TFIIB. The beta subunit shows ATP-dependent DNA-helicase activity and the region that binds RNA polymerase exhibits similarities with prokaryotic sigma factors. (NCI)]
Lidocaine Hydrochloride Ophthalmic Gel	NCIT_C132682	[An ophthalmic gel formulation containing the synthetic amide-type anesthetic lidocaine, with potential analgesic activity. Upon ophthalmic application, the active ingredient lidocaine binds to and blocks voltage-gated sodium channels in neuronal cell membranes. Lidocaine-mediated stabilization of neuronal membranes inhibits the initiation and conduction of nerve impulses, which numbs the nerves, prevents the trigemino-cardiac reflex and produces a reversible local anesthesia.]
GTF2F1 Gene	NCIT_C20652	[This gene plays a role in the maintenance of transcriptional integrity.]
Anti-LeY-CAR-transduced Autologous T-Lymphocytes	NCIT_C132683	[Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Lewis-Y (LeY), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, anti-LeY-CAR-transduced autologous T-lymphocytes specifically target and induce selective toxicity in LeY-expressing tumor cells. LeY, a difucosylated carbohydrate antigen, is overexpressed by a variety of cancer cell types.]
H3.3K27M-specific Peptide Vaccine	NCIT_C132684	[A vaccine composed of a peptide derived from histone H3.3 containing the amino acid substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunoactivating and antineoplastic activities. Upon administration of the H3.3K27M-specific peptide vaccine, the immune system may exert a cytotoxic T-lymphocyte (CTL)-mediated immune response against H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a variety of cancer cell types.]
Deuteporfin	NCIT_C132685	[A photosensitizing agent composed of four sub-porphyrin derivatives, methoxyethy-hydroxyethyl-dipropionic, di-methoxyethyl-dipropionic, hydroxyethy-vinyl-dipropionic and methoxyethy-vinyl-dipropionic, with potential photosensitizing activity upon photodynamic therapy (PDT) and potential diagnostic imaging activity. Upon intravenous administration, deuteporfin preferentially targets and accumulates in cancer cells, especially those in the lymphatic system. Following photoactivation with an appropriate wavelength, deuteporfin generates highly cytotoxic singlet oxygen species, and induces oxidative stress that results in the damage and death of cancer cells. In addition, deuteporfin could be used as a tracer in near-infrared (NIR) fluorescence lymph node mapping.]
RNA Polymerase II Subunit Gene	NCIT_C20660	[RNA polymerase II subunit genes encode DNA-dependent RNA polymerase II, a complex multisubunit enzyme that is responsible for the transcription of protein-coding genes. Ten to 14 subunits encoded by these genes range in size from 220 to 10 kD. The complex interacts with the promoter regions of genes as well as with a variety of elements and transcription factors to determine essentially all of the parameters that govern transcription, e.g., tissue and development specificity, stress response, etc. A fraction of the large subunit of Pol II (Pol II LS) is ubiquitinated after exposing cells to UV radiation or cisplatin. (NCI)]
POLR2A Gene	NCIT_C20661	[This gene plays a role in DNA-dependent transcription of RNA.]
Missed Indicator	NCIT_C93596	[Specifies whether a planned or preestablished event or activity did not occur.]
Missed Reason	NCIT_C93597	[The text and/or code that describes the rationale behind why an activity is not done.]
MRI Enhancement Rate Value	NCIT_C93598	[The numeric value to indicate an increase in voxel signal over time for an MRI, expressed as signal intensity units per second.]
Manufacture Date	NCIT_C93591	[The date and/or time on which a product is made.]
Keyword Code	NCIT_C93585	[A coded value specifying the words or phrases that best describe an entity and/or its context and content.]
Location Description	NCIT_C93589	[The textual representation of the physical location of the subject or entity.]
Intervention Group Quantity	NCIT_C93580	[An integer specifying the number of intervention groups.]
Funding Mechanism Code	NCIT_C93571	[A coded value specifying the unique identifier for the type of award an agency makes to support a program and within which it incorporates the terms and conditions for expending the funds and performing the work.]
Funding Type Code	NCIT_C93572	[A coded value specifying the kind of money and resources that are being used to fund the activity.]