Terminology Service < Semantic Lookup Platform

All terms in RGD

Label	Id	Description
Agt	rgd:2069	[ENCODES a protein that exhibits hormone activity; receptor ligand activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN activation of phospholipase C activity; aging; angiotensin-mediated drinking behavior; PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway via AT1 receptor; ASSOCIATED WITH anti-basement membrane glomerulonephritis; Aortic Calcification; atherosclerosis; FOUND IN cytoplasm; extracellular space; INTERACTS WITH (R)-mevalonic acid; (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine]
LOC108353316	rgd:11490472
Agtr1a	rgd:2070	[ENCODES a protein that exhibits angiotensin type I receptor activity; D1 dopamine receptor binding; protein kinase binding; INVOLVED IN activation of Janus kinase activity; aging; angiotensin-activated signaling pathway; PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; angiotensin III signaling pathway via AT1 receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH anti-basement membrane glomerulonephritis; asthma; Cardiomegaly; FOUND IN basolateral plasma membrane; cytoplasmic vesicle; dendrite; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 1-naphthyl isothiocyanate]
Agtr1b	rgd:2071	[ENCODES a protein that exhibits angiotensin type II receptor activity (inferred); INVOLVED IN angiotensin-activated signaling pathway; cellular response to dexamethasone stimulus; G protein-coupled receptor signaling pathway; PARTICIPATES IN angiotensin III signaling pathway via AT1 receptor; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; ASSOCIATED WITH Cardiomegaly; hypertension; Postoperative Cognitive Dysfunction; FOUND IN cell (inferred); integral component of membrane (inferred); INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil]
Agtr2	rgd:2072	[ENCODES a protein that exhibits transcription factor binding; angiotensin type II receptor activity (ortholog); INVOLVED IN aldosterone secretion; cell growth involved in cardiac muscle cell development; cellular response to dexamethasone stimulus; PARTICIPATES IN angiotensin III signaling pathway via AT2 receptor; angiotensin II signaling pathway via AT2 receptor; G protein mediated signaling pathway via Galphai family; ASSOCIATED WITH asthma; chronic kidney disease; congenital diaphragmatic hernia; FOUND IN perinuclear region of cytoplasm; plasma membrane; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 3',5'-cyclic GMP]
LOC108350516	rgd:11397092
Agxt	rgd:2073	[ENCODES a protein that exhibits alanine-glyoxylate transaminase activity; amino acid binding; serine-pyruvate transaminase activity; INVOLVED IN glycine biosynthetic process, by transamination of glyoxylate; pyruvate biosynthetic process; response to cAMP; PARTICIPATES IN alanine metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; ASSOCIATED WITH Vitamin B Deficiency; Hyperoxaluria (ortholog); nephrocalcinosis (ortholog); FOUND IN mitochondrial matrix; mitochondrion; peroxisome; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione]
Ahr	rgd:2074	[ENCODES a protein that exhibits nuclear receptor activity; toxic substance binding; aryl hydrocarbon receptor binding (ortholog); INVOLVED IN cellular response to 2,3,7,8-tetrachlorodibenzodioxine; cellular response to glucocorticoid stimulus; negative regulation of alkaline phosphatase activity; PARTICIPATES IN aryl hydrocarbon receptor signaling pathway; ASSOCIATED WITH Adult Pancreatic Cancer (ortholog); atherosclerosis (ortholog); Atrophy (ortholog); FOUND IN cytosol; nucleus; cytoplasm (ortholog); INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 1,10-phenanthroline]
LOC102550940	rgd:7703143
Ahsg	rgd:2075	[ENCODES a protein that exhibits receptor signaling protein tyrosine kinase inhibitor activity; INVOLVED IN animal organ regeneration; cellular response to insulin stimulus; cerebral cortex development; PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH 3MC syndrome 1 (ortholog); acute kidney failure (ortholog); Alopecia-Mental Retardation Syndrome 1 (ortholog); FOUND IN collagen-containing extracellular matrix; extracellular space; protein-containing complex; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,6-dinitrotoluene]
Ak1	rgd:2076	[ENCODES a protein that exhibits adenylate kinase activity; phosphotransferase activity, phosphate group as acceptor; nucleoside diphosphate kinase activity (ortholog); INVOLVED IN ADP biosynthetic process; AMP metabolic process; cerebellum development; PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; ASSOCIATED WITH middle cerebral artery infarction; myocardial infarction; Sarcopenia; FOUND IN neuron projection; perinuclear region of cytoplasm; sarcomere; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; acrylamide]
Ak2	rgd:2077	[ENCODES a protein that exhibits adenylate kinase activity; nucleobase-containing compound kinase activity; INVOLVED IN ADP biosynthetic process; AMP metabolic process; ATP metabolic process; PARTICIPATES IN adefovir pharmacokinetics pathway; tenofovir pharmacokinetics pathway; de novo purine biosynthetic pathway; ASSOCIATED WITH temporal lobe epilepsy; Charcot-Marie-Tooth disease dominant intermediate C (ortholog); Deafness (ortholog); FOUND IN cytoplasm; cytosol; mitochondrial intermembrane space; INTERACTS WITH (R)-adrenaline; 6-propyl-2-thiouracil; 7H-xanthine]
Ak4	rgd:2078	[ENCODES a protein that exhibits adenylate kinase activity (ortholog); nucleoside diphosphate kinase activity (ortholog); INVOLVED IN brain development; liver development; response to drug; PARTICIPATES IN de novo purine biosynthetic pathway; ASSOCIATED WITH acute kidney tubular necrosis; Chemical and Drug Induced Liver Injury; intellectual disability (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2,2-tetramine]
LOC102550180	rgd:7703147
Akap11	rgd:2079	[ENCODES a protein that exhibits kinase regulator activity; protein kinase A catalytic subunit binding; protein kinase A regulatory subunit binding; INVOLVED IN positive regulation of establishment of endothelial barrier; positive regulation of protein phosphorylation; PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Mouth Neoplasms (ortholog); FOUND IN cytoplasm; peroxisome; protein-containing complex; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,4-dinitrotoluene]
LOC103694645	rgd:9192945
Tfrc	rgd:70488	[ENCODES a protein that exhibits chaperone binding; Hsp70 protein binding; transferrin receptor activity; INVOLVED IN acute-phase response; aging; response to copper ion; PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; iron uptake pathway; ASSOCIATED WITH Acute-Phase Reaction; Chronic Cerebral Hypoperfusion; duodenal ulcer; FOUND IN cell surface; cytoplasm; extracellular exosome; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene]
LOC103694367	rgd:9192941
Cdk2	rgd:70486	[ENCODES a protein that exhibits cyclin binding; cyclin-dependent protein serine/threonine kinase activity; protein-containing complex binding; INVOLVED IN animal organ regeneration; cellular response to insulin stimulus; lens development in camera-type eye; PARTICIPATES IN G1/S transition pathway; interleukin-2 signaling pathway; mTOR signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; membranoproliferative glomerulonephritis; Optic Nerve Injuries; FOUND IN cytosol; intracellular membrane-bounded organelle; nucleus; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-mevalonic acid]
Ctnnb1	rgd:70487	[ENCODES a protein that exhibits cadherin binding; ionotropic glutamate receptor binding; nitric-oxide synthase binding; INVOLVED IN bone remodeling; cell-cell adhesion; cellular response to fibroblast growth factor stimulus; PARTICIPATES IN Wnt signaling, canonical pathway; altered Wnt signaling, canonical pathway; colorectal cancer pathway; ASSOCIATED WITH Alzheimer's disease; colon adenocarcinoma; colorectal cancer; FOUND IN adherens junction; cytoplasm; cytosol; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (R)-adrenaline]